Comparative Effects of 1α-hydroxycholecalciferol in Children and Adults with Renal Glomerular Osteodystrophy

  • R. G. Henderson
  • J. A. Kanis
  • J. G. G. Ledingham
  • D. O. Oliver
  • R. G. G. Russel
  • R. Smith
  • R. J. Walton

Abstract

Recent short-term studies have shown that microgram doses of both 1,25-dihydroxycholecalciferol (1,25-(OH)2-D3), the hormonally active metabolite of vitamin D, and lα-hydroxycholecalciferol (lα-OH-D3), a synthetic analogue can increase intestinal absorption of calcium in patients with chronic renal failure in whom large (mg) doses of vitamin D are ineffective (1, 4, 5, 6). In patients with renal osteodystrophy, these compounds may reduce plasma parathyroid hormone concentration and osteoclastic bone resorption (2) and increase the calcium content of the bones of the hands (3). There is, however, little published work on the long-term effects of 1,25-(OH)2-D3 or lα-OH-D3 in patients with renal osteodystrophy. The present paper describes the effects of lα-OH-D3 in four children and three adults studied for up to 14 months.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1976

Authors and Affiliations

  • R. G. Henderson
    • 1
    • 2
    • 3
  • J. A. Kanis
    • 1
    • 2
    • 3
  • J. G. G. Ledingham
    • 1
    • 2
    • 3
  • D. O. Oliver
    • 1
    • 2
    • 3
  • R. G. G. Russel
    • 1
    • 2
    • 3
  • R. Smith
    • 1
    • 2
    • 3
  • R. J. Walton
    • 1
    • 2
    • 3
  1. 1.Renal UnitChurchill HospitalOxfordEngland
  2. 2.Metabolic UnitNuffield Departments of Orthopaedic SurgeryOxfordEngland
  3. 3.Clinical MedicineUniversity of OxfordOxfordEngland

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