Nuclear Inclusions in Osteoclasts in Paget’s Bone Disease
Osteoclasts, relatively rare among bone cells in normal tissue as in most pathological conditions, are abundant in the case of Paget’s bone disease. Electron microscopy shows several cytological differences between these and normal osteoclasts (6). The most striking one is the presence of nuclear inclusions which appear to be specific to osteoclasts in this particular context (5). In structure, the inclusions are comparable to those associated with various viral infections and this suggests the possible action of an exogenous agent in Paget’s bone disease.
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