Destruction of Complement-Target Cell Complexes by Mononuclear Leukocytes

  • Hans J. Müller-Eberhard
  • Peter Perlmann
  • Hedvig Perlmann
  • Jorge A. Manni
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 1)


There are two primary mechanisms by which biological membranes may sustain irreversible damage in the course of immune reactions, one involving lymphocytes, the other humoral factors. Damage of membranes by sensitized mononuclear cells usually does not require participation of serum factors such as complement; and membrane damage by antibody and complement occurs without participation of cells. In the following, preliminary experiments will be reported which point out the existence of an additional mode of membrane damage in which non-sensitized mononuclear leukocytes and complement appear to cooperate. The early part of this work has been presented previously [1].
Tabelle 1.

In vitro model of mononuclear leukocyte-induced cell damage

1.Sensitized Lymphocyte (a) + Target Cell (a).

2.Sensitized Lymphocyte (b) + Antigen (b) + Target Cell (a).

3.Normal Lymphocyte + Antibody (a) + Target Cell (a).

4.Normal Lymphocyte + PHA + Target Cell.

5.Monocyte + Antibody (a) + Target Cell (a).


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Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • Hans J. Müller-Eberhard
    • 1
  • Peter Perlmann
  • Hedvig Perlmann
  • Jorge A. Manni
  1. 1.Department of Experimental PathologyScripps Clinic and Research FoundationLa JollaUSA

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