Abstract
Evidence of the spontaneous development of an autoimmune disease in laboratory animals was first reported in 1959 by Bielschowsky, Helyer and Howie. Mice of the strain NZB/Bl develop an autoimmune haemolytic anaemia. An incomplete antibody against red blood cells, reticulocytosis, splenomegaly and a depression of haematocrit were found.
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References
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Hobik, H.P. (1969). Histological Changes in NZB/NZW Mice. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-29237-2_18
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DOI: https://doi.org/10.1007/978-3-662-29237-2_18
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