Advertisement

Tumours arising from vertical transmission

  • Francesco Squartini
Part of the Handbuch der experimentellen Pharmakologie Handbook of Experimental Pharmacology book series (HEP, volume 16 / 13)

Abstract

The establishment of the first homozygous strains, many years ago, disclosed unexpected possibilities for specialized investigations in the fields of biological research. Today a large number of inbred strains, specially mouse strains, are available for different purposes. Whoever is familiar with the problems of cancer research knows that there are perhaps no strains at present which are completely free from the development of spontaneous neoplasms. The frequency and site of predilection of these so-called spontaneous tumours in laboratory animals are widely variable according to the animal strain, sex and environmental conditions. The intensive studies devoted, through many years, to some of these spontaneous tumours have decisively shown that they are mainly due to intrinsic causative factors acquired by vertical transmission.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Amano, S., and Y. Ichikawa: Electron microscopical aspects of developing modes of the cancer virus and the problem of “pseudovirus particles”. Acta Path. Japan 9, 455–479 (1959).Google Scholar
  2. Andervont, H. B.: Pulmonary tumors in mice. I. The susceptibility of the lungs of albino mice to the carcinogenic action of 1,2,5,6-dibenzanthracene. Publ. Hlth Rep. Wash. 52, 212–221 (1937).Google Scholar
  3. Andervont, H. B.: The influence of foster nursing upon the incidence of spontaneous mammary cancer in resistant and susceptible mice. J. nat. Cancer Inst. 1, 147–153 (1940).Google Scholar
  4. Andervont, H. B.: Spontaneous tumors in a subline of strain C 3 H mice. J. nat. Cancer Inst. 1, 737–744 (1941).Google Scholar
  5. Andervont, H. B.: Influence of environment on mammary cancer in mice. J. nat. Cancer Inst. 4, 579–581 (1944).Google Scholar
  6. Andervont, H. B.: Fate of the C3H milk influence in mice of strains C and C57 black. J. nat. Cancer Inst. 5, 383–390 (1945).Google Scholar
  7. Andervont, H. B.: The incidence of mammary tumors in mice of strains C311 and in descendants of fostered strain C. J. nat. Cancer Inst. 10, 193–200 (1949).PubMedGoogle Scholar
  8. Andervont, H. B.: Disappearance of the mammary tumor agent from Riii mice. Acta Un. int. Caner. 15, 124–127 (1959).Google Scholar
  9. Andervont, H. B.: In utero transmission of the mouse mammary tumor agent. J. nat. Cancer Inst. 31, 261–272 (1963).PubMedGoogle Scholar
  10. Andervont, H. B., and W. R. Bryan: Properties of the mouse mammary tumor agent. J. nat. Cancer Inst. 5, 143–149 (1944).Google Scholar
  11. Andervont, H. B., and T. B. Dunn: Mammary tumours in mice presumably free of the mammary tumor agent. J. nat. Cancer Inst. 8, 227–233 (1948a).PubMedGoogle Scholar
  12. Andervont, H. B., and T. B. Dunn: Efforts to detect a mammary-tumor agent in strain C mice. J. nat. Cancer Inst. 8, 235–240 (1948b).PubMedGoogle Scholar
  13. Andervont, H. B., and T. B. Dunn: Studies on the mammary-tumor agent of strain Riii mice. J. nat. Cancer Inst. 28, 159–185 (1962).PubMedGoogle Scholar
  14. Andervont, H. B., and W. J. Mceleney: The influence of foster nursing upon the incidence of spontaneous breast cancer in strain C3H mice. Publ. Hlth Rep. (Wash.) 54, 1597–1603 (1939).CrossRefGoogle Scholar
  15. Andervont, H. B.: Effect of ingestion of strain C311 milk in the production of mammary tumors in strain C3H mice of different ages. J. nat. Cancer Inst. 2, 13–16 (1941).Google Scholar
  16. Andervont, H. B.,HM. B. Shimkin, and W. R. Bryan: Technique suitable for quantitative studies on the mammary tumor inciter of mice. J. nat. Cancer Inst. 3, 309–318 (1942).Google Scholar
  17. Armstrong, E. C.: Observations on the nature of the oestrous cycle and on the effect upon it of the milk factor, in mice of two inbred strains, differing in mammary cancer incidence. Brit. J. Cancer 2, 59–69 (1948).PubMedCrossRefGoogle Scholar
  18. Armstrong, M. I., and A. W. Ham• Demonstration of milk factor in a C3H mouse mammary tumor after the tumor had been transferred 31 times in fertile eggs. Cancer Res. 10, 201–202 (1950).Google Scholar
  19. Aub, J. C., D. Karnofski, and L. E. TowNE: Sex hormone excretion rates in high and low tumor strains of mice. Cancer Res. 1, 737–741 (1941).Google Scholar
  20. Bagg, H. J.: Functional activity of the mammary gland in relation to extrachromosomal influence in the incidence of mammary tumors. Science 83, 374–375 (1936 a).Google Scholar
  21. Bagg, H. J.: Further studies on the relation of functional activity to mammary carcinoma in mice. Amer. J. Cancer 27, 542–550 (1936b).CrossRefGoogle Scholar
  22. Bang, F. B., and H. B. Andervont: Detection of the mammary tumor inciter (M.T.I.) in thin sections of spontaneous mouse tumors. J. appl. Physics 24, 1418 (1953).Google Scholar
  23. Bang, F. B., and H. B. Andervont:, and I. Vellisto • Electron microscopic evidence concerning the mammary tumor inciter (virus). I. An electron microscopic study of the spntaneous and induced mammary tumors of mice. Bull. Johns Hopk. Hosp. 98, 287–308 (1956).Google Scholar
  24. Bang, F. B., I. Vellisto, and R. Libert: Electron microscopic evidence concerning the mammary tumor inciter (virus). I. A study of normal and malignant cells from the mammary gland of mice. Bull. Johns Hopk. Hosp. 98, 255–285 (1956).Google Scholar
  25. Barbieri, G., F. Caschera e M. Olivi: La fase precancerosa morfologica: i noduli di iperplasia alveolare nella mammella del topo (Riii/Dm/Se substrain). Lay. Ist. Anat. Univ. Perugia 18, 89–106 (1958a).Google Scholar
  26. Barbieri, G., F. Caschera e M. Olivi: I noduli di iperplasia alveolare della mammella nelle femmine del topo, vecchie e vergini (Riii/Dm/Se e Balb/cf C3H/Cb/Se). Lay. Ist. Anat. Univ. Perugia 18,125–135 (1958 b).Google Scholar
  27. Barbieri, G., e M. Olivi: Il numero dei parti nelle femmine del topo appartenenti a “inbred strains” con diversa incidenza di cancro mammario, sottoposte al “forced breeding”. Lay. Ist. Anat. Univ. Perugia 18, 149–153 (1958).Google Scholar
  28. Barnes, W. A., and R. K. Cole: The effect of nursing on the incidence of spontaneous leukemia and tumors in mice. Cancer Res. 1, 99–101 (1941).Google Scholar
  29. Barnum, C. P., Z. B. Ball, J. J. Birrner, and M. B. Visscher: The milk agent in spontaneous mammary carcinoma. Science 100, 575–576 (1944).PubMedCrossRefGoogle Scholar
  30. Barnum, C. P., and R. A. Huseby: The chemical and physical characteristics of preparations containing the milk agent virus: A review. Cancer Res. 10, 523–529 (1950).PubMedGoogle Scholar
  31. Bashforv, R. F.: The incidence of cancer of the mamma in female mice of known age. Proc. Roy. Soc. B 81, 310–323 (1909).CrossRefGoogle Scholar
  32. Benedetti, E. L., and W. Bernhard • Recherches ultrastructurales sur le virus de la léucemie érythroblastique du poulét. J. Ultrastr. Res. 1, 309–336 (1958).CrossRefGoogle Scholar
  33. Bern, H. A.: Relation between sensitivity to lactogenic hormones and tumorigenesis in hyperplastic mammary nodules in C3H/Crgl mice. Proc. Soc. exp. Biol. (N. Y.) 112, 864–866 (1963).CrossRefGoogle Scholar
  34. Bern, H. A.: K. B. Deome, M. Alfert, and D. R. PrrElka• Morphologic and physiologic characterization of hyperplastic nodules in the mammary glands of the C3H/He Crgl mouse. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 565–573, L. Severi ed., Division of Cancer Research, Perugia 1958.Google Scholar
  35. Bern, H. A., and S. Nandi: Recent studies of the hormonal influence in mouse mammary tumori-genesis. In: Progress in Tumor Research, Vol. 2, pp. 90–144. F. Homburger ed. New York: S. Karger 1961.Google Scholar
  36. Bernhard, W.: Electron microscopy of tumor cells and tumor viruses. A review. Cancer Res. 18, 491–509 (1958).PubMedGoogle Scholar
  37. Bernhard, W.: The detection and study of tumor viruses with the electron microscope. Cancer Res. 20, 712–727 (1960).PubMedGoogle Scholar
  38. Bernhard, W., A. Bauer, M. Guerin et C. Oberling• Etude au microscope électronique de corpuscules d’aspect virusal dans des épithéliomas mammaires de la souris. Bull. Cancer 42, 163–178 (1955).Google Scholar
  39. Bernhard, W., A. Bauer, and N. Granboulan: Morphology of oncogenic and non-oncogenic mouse viruses. In: A Ciba Foundation Symposium on Tumour Viruses of Murine Origin, pp. 6–55, G. E. W. Wolstenholme and M. O’Connor eds., London: J. and A. Churchill Ltd. 1962.Google Scholar
  40. Bernhard, W., et M. GuiRin, Evaluation quantitative du virus dans les tumeurs mammaires spontanées ou graffées de différentes souches de souris et étude de ses rapports avec l’appareil de Golgi. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 627–639, L. Severi ed., Division of Cancer Research, Perugia 1958a.Google Scholar
  41. Bernhard, W., et M. GuiRin, Présence de particules d’aspect virusal dans les tissus tumoraux de souris atteintes de leucémie spontanée. C. R. Acad. Sci. (Paris) 247, 1802–1805 (1958b).Google Scholar
  42. Bernhard, W. et C. Oberling• Mise en évidence de corpuscules d’aspet virusal dans différentes souches de cancers mammaires de la souris. Acta Un. int. Caner. 12, 544–557 (1956).Google Scholar
  43. Biancifiori, C., E. Bucciarelli, F. E. Santilli e R. R.BaceHI: Cancerogenesi polmonare da idrazide dell’acido isonicotinico (Ini) e suoi metaboliti in topi Cba/Cb/Se substrain. Lay. Ist. Anat. Univ. Perugia 23, 209–220 (1963).Google Scholar
  44. Biancifiori, C., G. Lotti, and C. Martinez: Incidence of spontaneous mammary carcinoma in hybrid mice (C3H/Cb/Se x Balb/cfC/Cb/Se) from the 1st to the 7th generation. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 419–422, L. Severi ed., Division of Cancer Research, Perugia 1958.Google Scholar
  45. Biancifiori, C., e F. Squartini: Tumori mammari in ibridi suscettibili trattati con sperma di maschi ad alta incidenza. Lay. Ist. Anat. Univ. Perugia 18, 137–140 (1958).Google Scholar
  46. Bielschowsky, F.: Breast cancer and hyperplasia of the prolactin-secreting cells of the adenohypophysis in Nzy mice. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 481–489, L. Severi ed., Division of Cancer Research, Perugia 1958.Google Scholar
  47. Biancifiori, C., and E. S. Horning: Aspects of endocrine carcinogenesis. Brit. med. Bull. 14, 106–115 (1958).Google Scholar
  48. Bielschowsky, M., F. Bielschowsky, and D. Lindsay: A new strain of mice with a high incidence of mammary cancers and enlargement of the pituitary. Brit. J. Cancer 10, 688–699 (1956).PubMedCrossRefGoogle Scholar
  49. Bittner, J. J.: Some possible effects of nursing on the mammary gland tumor incidence in mice. Science 84, 162–163 (1936).PubMedCrossRefGoogle Scholar
  50. Bittner, J. J.: Breast cancer and mother’s milk. J. Hered. 28, 363–365 (1937).Google Scholar
  51. Bittner, J. J.: Relation of nursing to the extrachromosomal theory of breast cancer in mice. Amer. J.: Cancer 35, 90–97 (1939a).Google Scholar
  52. Bittner, J. J.: The influence of transplanted normal tissue on breast cancer ratios in mice. Publ. Hlth Rep. (Wash.) 54, 1827–1831 (1939b).CrossRefGoogle Scholar
  53. Bittner, J. J.: Breast and lung carcinoma in “A” stock mice. Publ. 111th Rep. (Wash.) 54, 380–392 (1939 c).Google Scholar
  54. Bittner, J. J.: Further studies on active milk influence in breast cancer production in mice. Proc. Soc. exp. Biol. (N. Y.) 45, 804–810 (1940).Google Scholar
  55. Bittner, J. J.: The preservation by freezing and drying in vacuo of the milk influence for the development of breast cancer in mice. Science 93, 527–528 (1941a).PubMedCrossRefGoogle Scholar
  56. Bittner, J. J.: Changes in the incidence of mammary carcinoma in mice of the A stock. Cancer Res. 1, 113–114 (1941 b).Google Scholar
  57. Bittner, J. J.: The influence of foster nursing on experimental breast cancer. Trans. Coll. Phycns Philad. 9, 129–143 (1941c).Google Scholar
  58. Bittner, J. J.: The milk influence of breast tumors in mice. Science 95, 462 463 (1942 a).Google Scholar
  59. Bittner, J. J.: Observations on the genetics of susceptibility for the development of mammary cancer in mice. Cancer Res. 2, 540–545 (1942b).Google Scholar
  60. Bittner, J. J.: Possible relationship of the estrogenic hormones, genetic susceptibility, and milk influence in the production of mammary cancer in mice. Cancer Res. 2, 710–721 (1942c).Google Scholar
  61. Bittner, J. J.: Inciting influences in the etiology of mammary cancer in mice. In: Research Conference on Cancer, pp. 63–96, American Association for the Advancement of Science, Washington 1945 a.Google Scholar
  62. Bittner, J. J.: Characteristics of the mammary tumor milk agent in serial dilution and blood studies. Proc. Soc. exp. Biol. (N. Y.) 59, 43 44 (1945b).CrossRefGoogle Scholar
  63. Bittner, J. J.: Causes and control of mammary cancer in mice. Harvey Lect. 42, 221–246 (1946). Transplantability of mammary cancer in mice associated with source of mammary tumor milk agent. Cancer Res. 7, 741–745 (1947).Google Scholar
  64. Bittner, J. J.: Some enigmas associated with the genesis of mammary cancer in mice. Cancer Res. 8, 625–639 (1948a).PubMedGoogle Scholar
  65. Bittner, J. J.: Propagation of the mammary tumor milk agent in tumors from C57 black mice. Proc. Soc. exp. Biol. (N. Y.) 67, 219–221 (1948b).CrossRefGoogle Scholar
  66. Bittner, J. J.: Recovery of the mammary tumor milk agent following transfer by the male parent. Cancer Res. 10, 204 (1950).Google Scholar
  67. Bittner, J. J.: Inherited hormonal mechanisms and mammary cancer in virgin female mice. Cancer Res. 11, 237 (1951).Google Scholar
  68. Bittner, J. J.: Transfer of the agent for mammary cancer in mice by the male. Cancer Res. 12, 387–398 (1952a).PubMedGoogle Scholar
  69. Bittner, J. J.: Studies on the inherited susceptibility and inherited hormonal influence in the genesis of mammary cancer in mice. Cancer Res. 12, 594–601 (1952b).PubMedGoogle Scholar
  70. Bittner, J. J.: Influence of the mammary-tumor agent on the genesis of mammary cancer in agent-free mice after male transmission. J. nat. Cancer Inst. 25, 177–199 (1960).PubMedGoogle Scholar
  71. Bittner, J. J.: Biological assay and serial passage of the mouse mammary tumour agent in mammary tumours from mothers and their hybrid progeny. In: A Ciba Foundation Symposium on Tumour Viruses of Murine Origin, pp. 56–81, G. E. W. Wolstenholme and M. O’Connor eds. London: J. and A. Churchill Ltd. 1962.Google Scholar
  72. C. A. Evans, and R. G. Green: Survival of the mammary tumor milk agent of mice. Science 101, 95–97 0 1945 ).Google Scholar
  73. C. A. Evans., and M. J. Frantz: Sensitivity of females of C stock to male infection with mammary tumor agent. Proc. Soc. exp. Biol. (N. Y.) 86, 698–701 (1954).CrossRefGoogle Scholar
  74. C. A. Evans., R. A. Huseby, M. B. Visscher, Z. B. Ball, and F. W. SMrrH: Mammary cancer and mammary structure in inbred stocks of mice and their hybrids. Science 99, 83–85 (1944). Blair, P. B.: A new strain of the mouse mammary tumor virus. Science 127, 518 (1958).Google Scholar
  75. C. A. Evans.: A mutation in the mouse mammary tumor virus. Cancer Res. 20, 635–642 (1960).Google Scholar
  76. C. A. Evans., S. M. Blair, W. R. Lyons, H. A. Bern, and C. H. Li: Effect of hormones and of parity on the occurrence of hyperplastic alveolar nodules and tumors in the mammary glands of female A/Crgl mice. Cancer Res. 20, 1640–1645 (1960).Google Scholar
  77. C. A. Evans., and K. B. Deome: Mammary tumor development in transplanted hyperplastic alveolar nodules of the mouse. Proc. Soc. exp. Biol. (N. Y.) 108, 289–291 (1961).CrossRefGoogle Scholar
  78. C. A. Evans., and K. B. Deome, and S. Nandi: The characteristics of the preneoplastic state in mouse mammary carcinogenesis. In: A Henry Ford Hospital International Symposium on Biological Interactions in Normal and Neoplastic Growth, pp. 371–389, M. J. Brennan and W. L. Simpson eds. Boston: Little, Brown and Company 1962.Google Scholar
  79. Bonser, G. M.: The effect of oestrone administration on the mammary glands of male mice of two strains differing greatly in their susceptibility to spontaneous mammary carcinoma. J. Path. Bact. 42, 169–176 (1936).CrossRefGoogle Scholar
  80. Bonser, G. M.: A microscopical study of the evolution of mouse mammary cancer: the effect of the milk factor and a comparison with the human disease. J. Path. Bact. 57, 413–422 (1946).CrossRefGoogle Scholar
  81. Bonser, G. M.: The evolution of mammary cancer induced in virgin female IF mice with minimal doses of locally-acting methylcholanthrene. J. Path. Bact. 68, 531–546 (1954).PubMedCrossRefGoogle Scholar
  82. Boot, L. M., O. MÜHlbock, G. RÖPcke, and W. Van Eggenhorst Tengbergen: Further investigations on induction of mammary cancer in mice by isografts of hypophyseal tissue. Cancer Res. 22, 713–727 (1962).PubMedGoogle Scholar
  83. Brunscmwig, A., and A. D. Bissel: Estrus cycles in mice of cancerous and non-cancerous strains. Arch. Surg. 33, 515–520 (1936).CrossRefGoogle Scholar
  84. Bryan, W. R., H. Kahler, and V. T. Riley: Attempts to demonstrate a viruslike principle in mammalian tumors by the yolk injection technique. In: Research Conference on Cancer, pp. 40–53, American Association for the Advancement of Science. Washington 1945.Google Scholar
  85. Bryan, W. R., H. Kahler, M. B. Shimkin, and H. B. Andervont: Extraction and ultracentrifugation of mammary tumor inciter of mice. J. nat. Cancer Inst. 2, 451–455 (1942).Google Scholar
  86. Burrows, H.: Biological actions of sex hormones, 2nd edition. London: Cambridge University Press 1949.Google Scholar
  87. Burrows, H., and C. Hoch-Ligeti: Effect of progesterone on the development of mammary cancer in C311 mice. Cancer Res. 6, 608–609 (1946).PubMedGoogle Scholar
  88. Caschera. F.: La «menopausa» nei topi femmine vergini (Riii/Dm/Se, C3Hb/Se, A/He/Se substrains). Lay. Ist. Anat. Univ. Perugia 19, 13–20 (1959).Google Scholar
  89. Caschera. F.: La «pseudogravidanza spontanea» in topi femmine vergini, isolate e coabitanti, del Balb/cf substrain. Lay. Ist. Anat. Univ. Perugia 20, 17–30 (1960a).Google Scholar
  90. Caschera. F.: Le variazioni cicliche estrali e le relative modificazioni degli organi sessuali, in relazione all’età ed alla coabitazione, in topi femmine vergini del Balb/cf substrain (sull’esame di 580 cicli). Lay. Ist. Anat. Univ. Perugia 20, 63–74 (1960b).Google Scholar
  91. Caschera. F.: e N. Maltzeff: Modificazioni nel topo in rapporto con l’attenuazione della funzione ovarica (in vergini del Balb/cf/Cb/Se substrain). Lay. Ist. Anat. Univ. Perugia 20. 253–262 (1960).Google Scholar
  92. Cloudman, A. D.: Spontaneous neoplasms in mice. In: Biology of the Laboratory Mouse, pp. 168–233, G. D. Snell ed., New York: Dover Publications Inc. 1956.Google Scholar
  93. Cole, H. A.: The mammary gland of the mouse during oestrous cycle, pregnancy and lactation. Proc. Roy. Soc. B 114, 136–161 (1933).CrossRefGoogle Scholar
  94. Consolandi, G., E. U. Veronesi: La diffusione metastatica del cancro della mammella. IV. Parallelo sull’andamento del fenomeno nell’uomo e negli “inbred strains” del topo. Lay. Ist. Anat. U. IV. Perugia 17, 213–240 (1957).Google Scholar
  95. Consolandi, G., e U. Veronesi: La diffusione metastatica del cancro mammario negli “inbred strains” del topo. Atti Soc. ital. Cancer. 1, 159–216 (1958).Google Scholar
  96. Cori, C. F.: The influence of ovariectomy on the spontaneous occurrence of mammary carcinoma in mice. J. Cancer Res. 10, 265–266 (1926).Google Scholar
  97. Cori, C. F.: The influence of ovariectomy on the spontaneous occurrence of mammary carcinoma in mice. J. exp. Med. 45, 983–991 (1927).PubMedCrossRefGoogle Scholar
  98. Cowie, A. T., and S. J. Folley: Endocrine aspects of mammary growth and function, particularly in relation to pituitary hormones. In: Endocrine Aspects of Breast Cancer, pp. 266–275, A. R. Currie ed., London: E. and S. Livingstone Ltd. 1958.Google Scholar
  99. Debruyn, W. M., and E. L. Benedetti: Ultrastructure of virus-like particles found in longterm cultures of mouse. In: Proceedings of the European Regional Conference on Electron Microscopy, Vol. 2, pp. 999–1003, A. L. Houwink and B. J. Spit eds., Delft: De Nederlandse Vereniging voor Electronenmicroscopie 1960.Google Scholar
  100. Deome, K. B.: The role of the mammary tumor virus in mouse mammary noduligenesis and tumorigenesis. In: Viruses, Nucleic Acids and Cancer, 17th Annual Symposium on Fundamental Cancer Research at the University of Texas M. D. Anderson Hospital and Tumor Institute, pp. 498–507. Baltimore: The Williams and Wilkins Company 1963.Google Scholar
  101. H. A. Bern, W. E. Berg, and L. E. Pissott: Radiophosphorus uptake by normal, hyper-plastic and tumorous mammary tissues of mice. Proc. Soc. exp. Biol. (N. Y.) 92, 55–58. (1956).CrossRefGoogle Scholar
  102. H. A. Bern, S. Nandi, D. R. Pitelka, and L. J. Faulkin JR.: The precancerous nature of the hyperplasticalveolar nodules found in the mammary glands of old female C3H/Crgl mice. In: Genetics and Cancer, pp. 327–348. Austin: Univ. Texas Press 1959 a.Google Scholar
  103. P. B. Blair, and L. J. Faulkin JR.: Some characteristics of the preneoplastic hyperplastic alveolar nodules of the C3H/Crgl mice. Acta Un. int. Caner. 17, 973–982 (1961).Google Scholar
  104. L. J. Faulkin JR., H. A. Bern, and P. B. Blair’ Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res. 19, 515–520 (1959b).PubMedGoogle Scholar
  105. S. Nandi, H. A. Bern, P. Blair, and D. Pitelka: The preneoplastic hyperplastic alveolar nodule as the morphological precursor of mammary cancer in mice. In: The Morphological Precursors of Cancer, pp. 349–368, L. Severi ed., Division of Cancer Research, Perugia. 1962.Google Scholar
  106. Deringer, M. K.: Occurrence of tumors, particularly mammary tumors, in agent-free strain mice. J. nat. Cancer Inst. 22, 995–1002 (1959).PubMedGoogle Scholar
  107. Deringer, M. K., W. E. Heston, and H. B. Andervont: Estrus in virgin strain C3H (high-tumor) and. virgin strain A (low-tumor) mice and in the reciprocal (A x C3H) F1 hybrids. J. nat. Cancer Inst. 5, 403–405 (1945).Google Scholar
  108. Dmooaowski, L.: Comparative potency of the mammary tumour agent of mice of different genetic constitutions. Brit. J. exp. Path. 26, 267–269 (1945).Google Scholar
  109. Dmooaowski, L.: Preservation of mammary tumour agent by desiccation of breast tumour tissue of mice. Brit. J. exp. Path. 27, 391–393 (1946).Google Scholar
  110. Dmooaowski, L.: Mammary tumour inducing factor and genetic constitution. Brit. J. Cancer 2, 94–102 (1948).CrossRefGoogle Scholar
  111. Dmooaowski, L.: Some data on the distribution of the milk factor. Brit. J. Cancer 3, 525–533 (1949).CrossRefGoogle Scholar
  112. Dmooaowski, L.: A study of the development of mammary tumours in hybrid mice. Brit. J. Cancer 7, 73–119 (1953a).CrossRefGoogle Scholar
  113. Dmooaowski, L.: The milk agent in the origin of mammary tumors in mice. Advanc. Cancer Res. 1, 103–172 (1953b).CrossRefGoogle Scholar
  114. Dmooaowski, L.: Progress in mammalian genetics and cancer. Discussion. J. nat. Cancer Inst. 15, 785–787 (1954).Google Scholar
  115. Dmooaowski, L.: A biological and biophysical approach to the study of the development of mammary cancer in mice. Acta Un. int. Caner. 12, 582–618 (1956).Google Scholar
  116. Dmooaowski, L.: Viruses and tumors in the light of electron microscope studies: A review. Cancer Res. 20, 977–1015 (1960).Google Scholar
  117. Dmooaowski, L.: Some recent studies on mouse tumor viruses: the Bittner mammary tumor virus and the Gross leukemia virus. Ann. Med. (Perugia) 54, 753–771 (1963 a).Google Scholar
  118. Dmooaowski, L.: The electron microscopic view of virus-host relationship in neoplasia. In: Progress in Tumor Research, Vol. 3, pp. 35–147, F. Homburger ed., New York: S. Karger 1963 b.Google Scholar
  119. Dmooaowski, L., and C. E. Grey: Subcellular structures of possible viral origin in some mammalian tumors. Ann. N. Y. Acad. Sci. 68, 559–615 (1957).CrossRefGoogle Scholar
  120. Dmooaowski, L., and C. E. Grey: F. Padgett, and J. A. Sykes: Studies on the structure of the mammary tumor-inducing virus (Bittner) and of leukemia virus (GRoss). In: Viruses, Nucleic Acids and Cancer, 17 th Annual Symposium on Fundamental Cancer Research at the University of Texas M. D. Anderson Hospital and Tumor Institute, pp. 85–121. Baltimore: The Williams and Wilkins Company 1963 a.Google Scholar
  121. Dmooaowski, L., and C. D. Haagensen: The distribution of the mammary-tumor inducing agent in the various constituents of the cytoplasm of mammary tumor cells in mice. Acta Un. int. Caner. 11, 646–653 (1955).Google Scholar
  122. Dmooaowski, L., and C. D. Haagensen:, and D. H. Moore: Studies of sections of normal and malignant cells of high and lowcancer-strain mice by means of electron microscope. Acta Un. int. Caner. 11, 640–645 (1955).Google Scholar
  123. Dmooaowski, L., and R. D. Passey: Unpublished data 1951. Quoted by L. Dmocaowsxl, 1953a.Google Scholar
  124. Dmooaowski, L., and R. D. Passey: Attempts at tumor virus isolation. Ann. N. Y. Acad. Sei. 54, 1035–1066 (1952).CrossRefGoogle Scholar
  125. Dmooaowski, L. L. O. Pearson, C. E. Grey, and J. A. Sykes: Studies on the behavior of the Bittner virus in mice of some apparently virus-free strains. Acta Un. int. Caner. 19, 276–279 (1963b).Google Scholar
  126. Dunn, T. B.: Morphology of mammary tumours in mice. In: The Physiopathology of Cancer, pp. 123–148, F. Homburger and W. H. Fishman eds., London: Cassell and Co. 1953.Google Scholar
  127. Duran-Reynals, F.: Virus-induced tumors and the virus theory of cancer. In: The Physiopathology of Cancer, 2nd edition, pp. 238–292, F. Homburger ed., London: Cassell and Co. 1958.Google Scholar
  128. Eversole, W. J.: Inhibition of azo dye carcinogenesis by adrenalectomy and treatment with desoxicorticosterone trimethylacetate. Proc. Soc. exp. Biol. (N. Y.) 96, 643–646 (1957).CrossRefGoogle Scholar
  129. Eversole, W. J. The rôle of the adrenal cortex in azo dye carcinogenesis. Lay. Ist. Anat. Univ. Perugia 18, 25–36 (1958).Google Scholar
  130. Fekete, E.: A comparative morphological study of the mammary gland in a high and a low tumor strain of mice. Amer. J. Path. 14, 557–578 (1938).PubMedGoogle Scholar
  131. Fekete, E.: Observations on three functional tests in a high tumor and a low tumor strain of mice. Amer. J. Cancer 38, 234–238 (1940).Google Scholar
  132. Fekete, E.: A comparative study of the ovaries of virgin mice of the dba and C57 black strains. Cancer Res. 6, 263–269 (1946).PubMedGoogle Scholar
  133. Fekete, E.:, and C. C. Little: Observations on mammary tumor incidence of mice born from transferred ova. Cancer Res. 2, 525–530 (1942).Google Scholar
  134. Fekete, E.:, and H. K. Otis: Observations on leukemia in Akr mice born from transferred ova and nursed by low leukemic mothers. Cancer Res. 14, 445 447 (1954).Google Scholar
  135. Fiore-Donati, L., and L. Chieco-Bianchi: Influence of host factors on development andtype of leukemia induced in mice by Graffi virus. J. nat. Cancer Inst. 32, 1083–1107 (1964).PubMedGoogle Scholar
  136. Foulns, L.: Mammary tumours in hybrid mice: A sex-factor in transplantation. Brit. J. Cancer 1, 362–370 (1947).CrossRefGoogle Scholar
  137. Foulns, L.: Mammary tumours in hybrid mice: The presence and transmission of the mammary tumour agent. Brit. J. Cancer 3, 230–239 (1949a).CrossRefGoogle Scholar
  138. Foulns, L.: Mammary tumours in hybrid mice: Growth and progression of spontaneous tumours. Brit. J. Cancer 3, 345–375 (1949 b).Google Scholar
  139. Foulds, L.: Mammary tumours in hybrid mice: Hormone responses of transplanted tumours. Brit. J. Cancer 3, 240–246 (1949c).PubMedCrossRefGoogle Scholar
  140. Foulns, L.: The experimental study of tumor progression: A review. Cancer Res. 14, 327–339 (19M). The histologic analysis of mammary tumors of mice. I. Scope of investigation and general principles of analysis. J. nat. Cancer Inst. 17, 701–711 (1956a).Google Scholar
  141. Foulns, L.: The histologic analysis of mammary tumors of mice. II. The histology of responsiveness and progression. The origins of tumors. J. nat. Cancer Inst. 17, 713–753 (1956b).Google Scholar
  142. Foulns, L.: The histologic analysis of mammary tumors of mice. Iii. Organoid tumors. J. nat. Cancer Inst. 17, 755–781 (1956 c).Google Scholar
  143. Foulns, L.: The histologic analysis of mammary tumors of mice. IV. Secretion. J. nat. Cancer Inst. 17, 783–801 (1956d).Google Scholar
  144. Foulns, L.: The development of mammary tumours. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 501–503, L. Severi ed., Division of Cancer Research, Perugia 1958.Google Scholar
  145. Friend, C.: Cell-free transmission in adult Swiss mice of a disease having the characters of a leukemia. J. exp. Med. 105, 307–318 (1957).PubMedCrossRefGoogle Scholar
  146. Fuller, R. H., E. Brown, and C. A. Mills: Environmental temperatures and spontaneous tumors in mice. Cancer Res. 1, 130–133 (1941).Google Scholar
  147. Furtado-Dias, M. T.: Spontaneous testicural tumours in mice of the H strain. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 505–512, L. Severi ed., Division of Cancer Research, Perugia, 1958.Google Scholar
  148. Gardner, W. U.: Estrogens in carcinogenesis. Arch. Path. 27, 138–170 (1939).Google Scholar
  149. Gardner, W. U.: Growth of the mammary glands in hypophysectomized mice. Proc. Soc. exp. Biol. (N. Y.) 45, 835–838 (1940).CrossRefGoogle Scholar
  150. Gardner, W. U.: The effect of estrogen on the incidence of mammary and pituitary tumors in hybrid mice. Cancer Res. 1, 345–358 (1941).Google Scholar
  151. Gardner, W. U.: Persistence and growth of spontaneous mammary tumors and hyperplastic nodules in hypophysectomized mice. Cancer Res. 2, 476–488 (1942).Google Scholar
  152. Gardner, W. U.: Hormonal aspects of experimental tumorigenesis. Adv. Cancer Res. 1, 173–232 (1953).PubMedCrossRefGoogle Scholar
  153. Gardner, W. U., and E. Allen: Malignant and non-malignant uterine and vaginal lesions in mice receiving estrogens and estrogens and androgens simultaneously. Yale J. Biol. Med. 12, 213–234 (1939).Google Scholar
  154. Gardner, W. U., and E. Allen C. A. Pfeiffer, J. J. Trentin, and J. T. Wolstenholme: Hormonal factors in experimental carcinogenesis. In: The Physiopathology of Cancer, pp. 225–297, F. Homburger and W. H. Fishman eds., Cassell and Co., London 1953.Google Scholar
  155. Gardner, W. U., and E. Allen G. M. Smith, and L. C. Strong: Stimulation of abnormal mammary growth by large amounts of estrogenic hormone. Proc. Soc. exp. Biol. (N. Y.) 33, 148–150 (1935).CrossRefGoogle Scholar
  156. Gardner, W. U., L. C. Strong, and G. M. Smith: The mammary glands of mature female mice of strains varying in susceptibility to spontaneous tumor development. Amer. J. Cancer 37, 510–517 (1939).Google Scholar
  157. Gillman, J, C Gilbert, and I. Spence: Phaeochromocytoma in the rat. Cancer 6, 494–511 (1953).PubMedCrossRefGoogle Scholar
  158. Gomez, E. T., and C. W. Turner: Effects of thyroxine and galactin on lactation in hypophysectomized guinea pig. Proc. Soc. exp. Biol. (N. Y.) 36, 80–81 (1937).CrossRefGoogle Scholar
  159. Gorer, P. A., and L. W. Law: Attempt to demonstrate neutralizing antibodies to the mammary tumour “milk agent” in mice. Brit. J. Cancer 3, 90–93 (1949).PubMedCrossRefGoogle Scholar
  160. Grad, B.: The influence of hyper-and hypothyroidism on the incidence of lymphatic leukemia in Akr mice. Cancer Res. 17, 266–271 (1957).PubMedGoogle Scholar
  161. Graff, S., D. H. Moore, W. M. Stanley, H. T. Randall, and C. D. Haagensen: The milk agent. Acta Un. int. Caner. 6, 191–196 (1948).Google Scholar
  162. Isolation of mouse mammary carcinoma virus. Cancer 2, 755–762 (1949).Google Scholar
  163. Graff, S., H. T. Randall, G. E. Carpenter, and C. D. Haagensen: The milk factor in blood. Science 104, 289 (1946).CrossRefGoogle Scholar
  164. Graffi, A.: Chloroleukemia of mice. Ann. N. Y. Acad. Sci. 68, 540–558 (1957).PubMedCrossRefGoogle Scholar
  165. Green, R. G.: Cytotoxic property of mouse cancer antiserum. Proc. Soc. exp. Biol. (N. Y.) 1, 113–114 (1946).CrossRefGoogle Scholar
  166. Green, R. G., and J. J. Bittner: Neutralization of mouse mammary cancer virus with antiserum. Cancer Res. 6, 499 (1946).Google Scholar
  167. Green. R. G., M. M. Mosey, and J. J. Bittner: Antigenic character of cancer milk agent in mice. Cancer Res. 5, 588 (1945).Google Scholar
  168. Green. R. G., M. M. Mosey, and J. J. Bittner: Antigenic character of the cancer milk agent in mice. Proc. Soc. exp. Biol. (N. Y.) 61, 115–117 (1946).CrossRefGoogle Scholar
  169. Greene, H. S. N.: Toxemia of pregnancy in the rabbit: Clinical manifestations and pathology. J. exp. Med. 65, 809–832 (1937).PubMedCrossRefGoogle Scholar
  170. Greene, H. S. N.: Toxemia of pregnancy in the rabbit: II. Etiological considerations with special reference to hereditary factors. J. exp. Med. 67, 369–388 (1938).PubMedCrossRefGoogle Scholar
  171. Greene, H. S. N.: Uterine adenomata in the rabbit: Iii. Susceptibility as a function of constitutional factors. J. exp. Med. 73, 273–292 (1941).PubMedCrossRefGoogle Scholar
  172. Greene, H. S. N., and B. L. Newton: Evolution of cancer of the uterine fundus in the rabbit. Cancer 1, 82–99 (1948).PubMedCrossRefGoogle Scholar
  173. Greene, H. S. N., and J. A. Saxton JR.: Uterine adenomata in the rabbit: I. Clinical history, pathology and preliminary transplantation experiments. J. exp. Med. 67, 691–708 (1938).PubMedCrossRefGoogle Scholar
  174. Gross, L.: “Spontaneous” leukemia developing in C 3 H mice following inoculation, in infancy, with AK leukemic extracts, or AK embryos. Proc. Soc. exp. Biol. (N. Y.) 76, 27–32 (1951 a).Google Scholar
  175. Gross, L.: Pathogenic properties and “vertical” transmission of the mouse leukemia agent. Proc. Soc. exp. Biol. (N. Y.) 8, 342–348 (1951 b).Google Scholar
  176. Gross, L.: Development and serial cell-free passage of a highly potent strain of mouse leukemia virus. Proc. Soc. exp. Biol. (N. Y.) 94, 761–771 (1957).CrossRefGoogle Scholar
  177. Gross, L.: Viral etiology of mouse leukemia. Advanc. Cancer Res. 6, 149–180 (1961 a).Google Scholar
  178. Gross, L.: Oncogenic viruses. New York: Pergamon Press 1961 b.Google Scholar
  179. Gross, L.: Studies on pathogenic properties and natural transmission of a mouse leukaemia virus. In: A Ciba Foundation Symposium on Tumour Viruses of Murine Origin, pp. 159–175, G. E. W. Wolstenholme and M. O’CoNNoR eds., London: J. and A. Churchill Ltd. 1962.Google Scholar
  180. Guérin, M.: Coprs d’inclusion dans les adénocarcinomes mammaires de la souris. Bull. Cancer 42, 14–28 (1955).Google Scholar
  181. Gulik, P. J. Van, and R. Korteweo: Susceptibility to follicular hormone and disposition to mammary cancer in female mice. Amer. J. Cancer 38, 506–515 (1940a).Google Scholar
  182. Gulik, P. J. Van, and R. Korteweo: The anatomy of the mammary gland in mice with regard to the degree of its disposition for cancer. Ned. Akad. Wettenschappen 43, 891–900 (1940b).Google Scholar
  183. Haaland, M.: Spontaneous tumours in mice. A. R. imp. Cancer Res. Fd. 4, 1–113 (1911).Google Scholar
  184. Haddow, A.: The breast as the fountain of cancer lore. In: Proceedings of the II International Symposium on Mammary Cancer, Opening Lecture, pp XxxviiXlviii, L. Severi ed., Division of Cancer Research, Perugia, 1958.Google Scholar
  185. Hamilton, J. B., M. Hollander, and H. B. Andervont: Note on the increased rate of nail growth in mice carrying the milk agent for mammary cancer. J. nat. Cancer Inst. 20, 409–415 (1958).PubMedGoogle Scholar
  186. Harkness, M. N., H. A. Bern, M. Alfert, and N. O. Goldstein: Cytochemical studies of hyperplastic alveolar nodules in the mammary gland of the C3H/HeCrgl mouse. J. nat. Cancer Inst. 19, 1023–1033 (1957).PubMedGoogle Scholar
  187. Harven, E. DE: Etudes au microscope électronique de la leucémie de Friend et d’autres cancers de la souris également associés à la présence de particules virusales. Rev. belge Path. 2S, 7–136 (1961).Google Scholar
  188. Harven, E. DE:, and C. Friend: Electron microscopy of Swiss mouse leukemia virus. In: Symposium on Phenomena of the Tumor Viruses, J. W. Beard ed., National Cancer Institute Monograph No. 4, 291–297, 1960.Google Scholar
  189. Heilman, F. R.: On yolk sac cultivation and virus induction of malignant tumors. In: Research Conference on Cancer, pp. 54–55, Americal Association for the Advancement of Science, Washington, 1945.Google Scholar
  190. Heiman, J.: The effect of progesterone and testosterone propionate on the incidence of mammary cancer in mice. Cancer Res. 5, 426–430 (1945).Google Scholar
  191. Heston, W. E.: Genetic analysis of susceptibility to induced pulmonary tumors in mice. J. nat. Cancer Inst. 3, 69–78 (1942a).Google Scholar
  192. Heston, W. E.: Inheritance of susceptibility to spontaneous pulmonary tumors in mice. J. nat. Cancer Inst. 3, 79–82 (1942b).Google Scholar
  193. Heston, W. E.: Genetics of mammary tumors in mice. In: A Symposium on Mammary Tumors in Mice, pp. 55–84, F. R. Moulton ed., American Association for the Advancement of Science, Washington, 1945.Google Scholar
  194. Heston, W. E.: Paths of gene action in mammary-tumor development in mice. J. nat. Cancer Inst. 7, 79–85 (1946).PubMedGoogle Scholar
  195. Heston, W. E.: Rôle of genes and their relationship to extrachromosomal factors in the development of mammary gland tumours in mice. Brit. J. Cancer 2, 87–90 (1948).PubMedCrossRefGoogle Scholar
  196. Heston, W. E.: Localization of gene action in the causation of lung and mammary gland tumors in mice. J. nat. Cancer Inst. 15, 775–783 (1954).PubMedGoogle Scholar
  197. Heston, W. E.: Mammary tumors in agent-free mice. Ann. N. Y. Acad. Sei. 71, 931–942 (1958).CrossRefGoogle Scholar
  198. Heston, W. E.: Complete inhibition of occurrence of spontaneous hepatomas in highly susceptible (C311 x Ybr)F1 male mice by hypophysectomy. J. nat. Cancer Inst. 31, 467–474 (1963).PubMedGoogle Scholar
  199. Heston, W. E.: Induction of mammary gland tumors in strain C57 BL/He mice by isografts of hypophyses. J. nat. Cancer Inst. 32, 947–955 (1964).Google Scholar
  200. Heston, W. E., and H. B. Andervont: Importance of genetic influence on the occurrence of mammary tumors in virgin female mice. J. nat. Cancer Inst. 4, 403–407 (1944).Google Scholar
  201. Heston, W. E., M. K. Deringer, and H. B. Andervont: Gene-milk agent relationship in mammary tumor development. J. nat. Cancer Inst. 5, 289–307 (1945).Google Scholar
  202. Heston, W. E., and T. B. Dunn: Tumor development of susceptible strain A and resistant strain L lung transplants in Lai’, hosts. J. nat. Cancer Inst. 11, 1057–1071 (1951).PubMedGoogle Scholar
  203. Heston, W. E., G. Vlahakis, and M. K. Deringer: High incidence of spontaneous hepatomas and the increase of this incidence with urethan in C3H, C 3 Hf, and C 3 He male mice. J. nat. Cancer Inst. 24, 425–435 (1960).PubMedGoogle Scholar
  204. Heston, W. E., G. Vlahakis, and Y. Tsubura: Strain DD, a new high mammary tumor strain, and comparison of DD with strain C3H. J. nat. Cancer Inst. 32, 237–251 (1964).PubMedGoogle Scholar
  205. Hummel, K. P., and C. C. Little: Studies on the mouse mammary tumor agent. I. The agent in blood and other tissues in relation to physiologic or endocrine state of the donor. Cancer Res. 9, 129–134 (1949).PubMedGoogle Scholar
  206. Hummel, K. P., and C. C. Little: Comparison of the virulence of the mammary-tumor agent from four strains of mice. J. nat. Cancer Inst. 23, 813–821 (1959).PubMedGoogle Scholar
  207. Hummel, K. P., and C. C. Little, and S. B. Heddy: Studies on the mouse mammary tumor agent. II. The neutralization of the agent by placenta. Cancer Res. 9, 135–136 (1949).PubMedGoogle Scholar
  208. Huseby, R. A., Z. B. Ball, and M. B. Visscher: Further observations on the influence of simple caloric restriction on mammary cancer incidence and related phenomena in C 3H mice. Cancer Res. 5, 40–46 (1945).Google Scholar
  209. Huseby, R. A., C. P. Barnum, and J. J. Bittner: Titration of the milk agent virus in milk and lactating mammary gland cells. Cancer Res. 10, 516–520 (1950).PubMedGoogle Scholar
  210. Huseby, R. A., and J. J. Bittner: A comparative morphological study of the mammary glands with reference to the known factors influencing the development of mammary carcinoma in mice. Cancer Res. 6, 240–255 (1946).PubMedGoogle Scholar
  211. Huseby, R. A., and J. J. Bittner: Comparative studies of estrous cycles in relation to mammary tumor milk agent. Cancer Res. 7, 722 (1947).Google Scholar
  212. Huseby, R. A., and J. J. Bittner: Studies on the inherited hormonal influence. Acta Un. int. Caner. 6, 197–205 (1948). Ichikawa, Y., and S. Amano • A new type of virus found in a spontaneous mammary tumorGoogle Scholar
  213. Huseby, R. A., and J. J. Bittner: of SL mice and its proliferating modus observed in ultra-thin sections under the electron microscope. Gann 49, 57–64 (1958).Google Scholar
  214. Iglesias, R., W. H. Sternberg, and A. Segaloff: A functional ovarian tumor occurring spontaneously in a rat. Cancer Res. 10, 226 (1950).Google Scholar
  215. Imagawa, D., J. J. Bittner, and J. T. Syvertox: Cytotoxic studies on mouse mammary cancer cells. Cancer Res. 10, 226–227 (1950).Google Scholar
  216. Imagawa, D., R. G. Green, and H. O. Halvorson: A precipitin test for antigens present in mouse tissue containing the milk agent. Proc. Soc. exp. Biol. (N. Y.) 68, 162–166 (1948).CrossRefGoogle Scholar
  217. Imagawa, D., J. T. Syverton, and J. J. Bittner: The cytotoxic effect in vitro of antiserum upon heterologous mouse mammary cancer cells. Cancer Res. 11, 259 (1951).Google Scholar
  218. The cytotoxicity of serum for mouse mammary cancer cells. I. The effects of admixture in vitro upon homoiotransplantability. Cancer Res. 14, 1–7 (1954).Google Scholar
  219. Jesse, M. J., and C. D. Haagensen: Unpublished data, 1963. Quoted by D. H. Moore and M. J. Lyons, 1963 b.Google Scholar
  220. Jones, E. E.: A comparative study of hyperplastic nodules in mammary glands of mice with and without the mammary tumor inciter. Acta Un. int. Caner. 7, 263–265 (1951).Google Scholar
  221. Kaplan, H. S., C. S. Nagareda, and M. B. Brown: Endocrine factors and radiation-induced lymphoid tumors of mice. In: Recent Progress in Hormone Research, Vol. X, pp. 293–338, G. Pincus ed., New York: Academic Press 1954.Google Scholar
  222. Kinosita, R., J. O. Ericksen, D. M. Armen, M. E. Dolch, and J. P. Ward: Electron microscope study of mouse mammary carcinoma tissue. Exp. Cell Res. 4, 353–361 (1953).CrossRefGoogle Scholar
  223. Kirschbaum, A., J. R. Saphiro, and H. W. Mixer: Synergistic action of leukemogenic agents. Cancer Res. 13, 262–268 (1953).PubMedGoogle Scholar
  224. Klein, E., and G. Klein: A system for the detection of single gene mutations in mouse tumors. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 709–712, L. Severi ed., Division of Cancer Research, Perugia, 1958a.Google Scholar
  225. Klein, G., and E. Klein: Some experiments on the mechanism of progression in mouse mammary carcinomas. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 713–717, L. Severi ed., Division of Cancer Research, Perugia, 1958b.Google Scholar
  226. Korteweg, R.: Genetically determined differences in hormone production possible factor influencing susceptibility to mammary cancer in mice. Brit. J. Cancer 2, 91–94 (1948).Google Scholar
  227. Lacassagne, A.: Tentatives pour modifier, par la progéstérone ou par la testostérone, l’apparition des adénocarcinomes mammaires provoqués par l’oestrone chez la souris. C. R. Soc. Biol. (Paris) 126, 385–387 (1937).Google Scholar
  228. Lasfargues, E. Y.: Concerning the rôle of insulin in the differentiation and functional activity of mouse mammary tissues. Exp. Cell. Res. (1963) (in press).Google Scholar
  229. Lasfargues, E. Y., and D. G. Feldman: Hormonal and physiological background in the production of B particles by the mouse mammary epithelium in organ cultures. Cancer Res. 23, 191–196 (1963).Google Scholar
  230. Lasfargues, E. Y., D. H. MooRE, and M. R. Murray: Maintenance of the milk factor in cultures of mouse mammary epithelium. Cancer Res. 18, 1281–1285 (1958).PubMedGoogle Scholar
  231. Lasfargues, E. Y., D. H. MooRE, and M. R. Murray:, and C. D. Haagensen: Production of the milk agent in cultures of mouse mammary carcinoma. J. Biophys. Biochem. Cytol. 5, 93–96 (1959).PubMedCrossRefGoogle Scholar
  232. Lasfargues, E. Y., and M. R. Murray: Hormonal influences on the differentiation and growth of embryonic mouse mammary glands in organ cultures. Develop. Biol. 1, 413–435 (1959).CrossRefGoogle Scholar
  233. Lasfargues, E. Y., and M. R. Murray:, and D. H. Moore: Cultivation of the mouse mammary carcinoma virus. In: Symposium on Phenomena of the Tumor Viruses, J. W. Beard ed., National Cancer Institute Monograph, No. 4, 151–166, 1960.Google Scholar
  234. Lathrop, A. E. C., and L. Loeb: The influence of pregnancies on the incidence of cancer in mice. Proc. Soc. exp. Biol. (N. Y.) 11, 38–41 (1913).CrossRefGoogle Scholar
  235. Law, L. W.: Effect of pseudopregnancy on mammary carcinoma incidence in mice of the A stock. Proc. Soc. exp. Biol. (N. Y.) 48, 486–487 (1941).CrossRefGoogle Scholar
  236. Law, L. W.: The effect of gonadectomy and adrenalectomy on the appearance and incidence of spontaneous lymphoid leukemia in C58 mice. J. nat. Cancer Inst. 8, 157–159 (1947).PubMedGoogle Scholar
  237. Law, L. W.: Genetic studies in experimental cancer. Advanc. Cancer Res. 2, 281–352 (1954).CrossRefGoogle Scholar
  238. Law, L. W.: Present status of nonviral factors in the etiology of reticular neoplasms of the mouse. Ann N Y Acad. Sci. 68, 616–635 (1957).PubMedCrossRefGoogle Scholar
  239. Leonard, S. L., and R. P. Reece: Failure of steroid hormones to induce mammary growth in hypophysectomized rats. Endocrinology 30, 32–36 (1942).CrossRefGoogle Scholar
  240. Lieberman, M., and H. S. Kaplan: Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice. Science 130, 387–388 (1959).PubMedCrossRefGoogle Scholar
  241. Lippincott, S. W., J. E. Edwards, H. G. Grady, and H. L. Stewart: A review of some spontaneous neoplasms in mice. J. nat. Cancer Inst. 3, 199–210 (1942).Google Scholar
  242. Little, C. C.: Evidence that cancer is not a simple mendelian recessive. J. Cancer Res. 12, 30–46 (1928).Google Scholar
  243. Little, C. C., and J. Pearson: The results of a “functional test” in a strain of mice (C57 Black) with a low breast tumor incidence. Amer. J. Cancer 38, 224–233 (1940).Google Scholar
  244. Loeb, L.: Further investigations on the origin of tumors in mice. Internal secretion as a factor in the origin of tumors. J. Med. Res. 40, 477–496 (1919).PubMedGoogle Scholar
  245. Loeb, L., and M. M. Kirtz: The effects of transplants of anterior lobes of the hypophysis on the growth of the mammary gland and on the development of mammary gland carcinoma in various strains of mice. Amer. J. Cancer 36, 56–82 (1939).Google Scholar
  246. Lyons, M. J., and D. H. MooRE: Purification of the mouse mammary tumour virus. Nature (Lond.) 194, 1141–1142 (1962).CrossRefGoogle Scholar
  247. Macdowell, E. C., J. S. Potter, and M. J. Taylor: Mouse leukemia. Xii. The rôle of genes in spontaneous cases. Cancer Res. 5, 65–83 (1945).Google Scholar
  248. Man, J. C. H. DE, and T. G. Van Rijssel: Electron microscopy of tissue of the mammary glands and tumors in old mice with special reference to mitochondrial size. J. nat. Cancer Inst. 26, 919–947 (1961).Google Scholar
  249. Martinez, C.: Factors affecting the tranplantability and metastatic growth of tumors in mice. Ann Med. (Perugia) 48, 315–328 (1957).Google Scholar
  250. Mcendy, D. P., M. C. BooN, and J. Furth: On the role of thymus, spleen and gonads in the development of leukemia in a high-leukemia stock of mice. Cancer Res. 4, 377–383 (1944).Google Scholar
  251. Metcalf, D.: The thymic origin of the plasma lymphocytosis stimulating factor. Brit. J. Cancer 10, 442–457 (1956).PubMedCrossRefGoogle Scholar
  252. Metcalf, D.: Thymus lymphocytosis stimulating activity in high and low leukemia strains of mice. Proc. Amer. Ass. Cancer Res. 2, 231–232 (1957).Google Scholar
  253. Metcalf, D.: Adrenal cortical function in high-and low-leukemia strains of mice. Cancer Res. 20, 1347–1353 (1960).PubMedGoogle Scholar
  254. Miller, E. W., J. W. Orr, and F. O. Pybus: The effect of oestrone on the mouse skeleton, with particular reference to the Newcastle bone tumor (Nbt) strain. J. Path. Bact. 55, 137–150 (1943).CrossRefGoogle Scholar
  255. Miller, E. W., and F. C. Pybus: Effect of foster nursing on incidence of spontaneous mammary carcinoma in two inbred strains of mice. Cancer Res. 5, 94–101 (1945).Google Scholar
  256. Miller, J. F. A. P.: Etiology and pathogenesis of mouse leukemia. Advanc. Cancer Res. 6, 291–368 (1961).CrossRefGoogle Scholar
  257. Miller, E. W., Rôle of the tymus in virus-induced leukaemia. In: A Ciba Foundation Symposium on Tumour Viruses of Murine Origin, pp. 262 283, G. E. W. Wolstenholme and M. O’CoNnor eds., London: J. and A. Churchill Ltd. 1962.Google Scholar
  258. Miroff, G., and D. G. Feldman: Production and release of virus-like particles by cultures of agent-free ascites cells. J. nat. Cancer Inst. 31, 807–825 (1963).PubMedGoogle Scholar
  259. Mixner, J. P., and C. W. Turner: Role of estrogen in the stimulation of mammary lobule-alveolar growth by progesterone and by the mammogenic lobule-alveolar growth factor of the anterior pituitary. Endocrinology 30, 591–597 (1942).CrossRefGoogle Scholar
  260. Moloney, J. B.: Biological studies on a lymphoid-leukemia virus extracted from sarcoma 37. I. Origin and introductory investigations. J. nat. Cancer Inst. 24, 933–951 (1960).Google Scholar
  261. Moloney, J. B.: Discussion of the Gross’s paper. In: A Ciba Foundation Symposium on tumour Viruses of Murine Origin, pp. 171–172, G. E. W. Wolstenholme and M. O’Connor eds., London: J. and A. Churchill Ltd. 1962.Google Scholar
  262. Moore, D. H.: Some preparations of the mouse mammary carcinoma agent. In: Proc. nat. Cancer Conf. 1, 299–303 (1952).Google Scholar
  263. Moore, D. H.: On the identification and characterization of the milk agent. In: A Ciba Foundation Symposium on Tumour Viruses of Murine Origin, pp. 107 137, G. E. W. Wolstenholme and M. O’CoxxoR eds., London: J. and A. Churchill Ltd. 1962.Google Scholar
  264. Moore, D. H.: Mouse mammary tumour agent and mouse mammary tumours. Nature (Lond.) 198, 429–433 (1963).CrossRefGoogle Scholar
  265. Moore, D. H.: H. C. Chopra, P. D. Lunger, and M. J. Lyons: Unpublished data. Quoted by D. H. Moore, 1963.Google Scholar
  266. Moore, D. H., E. Y. Lasfargues, M. R. Murray, C. D. Haagensen, and E. C. Pollard: Correlation of physical and biological properties of mouse mammary tumor agent. J. biophys. biochem. Cytol. 5, 85–92 (1959).PubMedCrossRefGoogle Scholar
  267. Moore, D. H., and M. J. Lyons: Purification and subsequent studies of the mouse mammary tumor virus. In: Electron Microscopy, Fifth International Congress for Electron Microscopy, Vol. 2, pp. MM-6, Sidney S. Breese JR. ed., New York: Academic Press Inc. 1962.Google Scholar
  268. Moore, D. H., and M. J. Lyons: Electrophoretic separation of the mouse mammary tumor virus. J. nat. Cancer Inst. 31, 1255–1273 (1963a).PubMedGoogle Scholar
  269. Moore, D. H., and M. J. Lyons: Studies of replication and properties of the Bittner virus. In: Viruses, Nucleic Acids and Cancer (17th Annual Symposium on Fundamental Cancer Research at the University of Texas M. D. Anderson Hospital and Tumor Institute), pp. 224–242. Baltimore: Williams and Wilkins Company, 1963b.Google Scholar
  270. Moore, D. H., E. C. Pollard, and C. D. Haagensen: Further correlations of physical and biological properties of mouse mammary tumor agent. Fed. Proc. 21, 942–946 (1962).Google Scholar
  271. Morris, H. P.: Diet and some other environmental influences in the genesis and growth of mammary tumours in mice. In: A Symposium on Mammary Tumors in Mice, pp. 140 161, F. R. Moulton ed., American association for the Advancement of Science, Washington, 1945 a.Google Scholar
  272. Morris, H. P.: Some nutritional factors influencing the origin and development of cancer. J. nat. Cancer Inst. 6, 1–17 (1945b).Google Scholar
  273. Mühlrock, O.: On the susceptibility of different inbred strains of mice for oestrone. Acta brev. neerl. Physiol. 15, 18–20 (1947).Google Scholar
  274. The oestrone sensitivity of the mammary gland in female mice of various strains. Acta brev. neerl. Physiol. 16, 22–27 (1948).Google Scholar
  275. The sensitivity of the mammary gland to oestrone in different strains of mice with and without mammary tumor agent. Acta endocr. (Kbh.) 3, 105–110 (1949).Google Scholar
  276. Mammary tumor-agent in the sperm of high-cancer-strain male mice. J. nat. Cancer Inst. 10, 861–864 (1950a).Google Scholar
  277. Non occurrence of mammary-tumor agent in the excreta of high-cancer-strain mice. Acta physiol. pharmacol. neerl. 1, 645–650 (1950b).Google Scholar
  278. Note on the influence of the number of litters upon the incidence of mammary tumors in mice. J. nat. Cancer Inst. 10, 1259–1262 (1950 c).Google Scholar
  279. Studies on the transmission of the mouse mammary tumor agent by the male parent. J. nat. Cancer Inst. 12, 819–837 (1952).Google Scholar
  280. Experimentelle Untersuchungen über die Genese des Mammakarzinoms. Schweiz. Med. Wschr. 85, 387–390 (1955 a).Google Scholar
  281. Tumours of the hypophysis and thyroid in mice. Acta endocr. (Kbh.) 18, 445–446 (1955b). The hormonal genesis of mammary cancer. Advanc. Cancer Res. 4, 371–391 (1956). Hormones as carcinogenic factors. Ann. Med. (Perugia) 48, 125–132 (1957).Google Scholar
  282. Studies on the hormone dependence of experimental breast tumours in mice. In: Endocrine Aspects of Breast Cancer, pp. 291 296, A. R. Currie ed., London: E. and S. Livingstone Ltd. 1958 a.Google Scholar
  283. Mammary cancer in human beings and in animals. A comparison. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 811 816, L. Severi ed., Division of Cancer Research, Perugia, 1958b.Google Scholar
  284. Hlbock, O., and L. M. Boot: Induction of mammary cancer in mice without the mammary tumor agent by isografts of hypophyses. Cancer Res. 19, 402–412 (1959).PubMedGoogle Scholar
  285. Hlbock, O., and L. M. Boot: Natural factors influencing host responses. In: Symposium of Phenomena of the Tumor Viruses, J. W. Beard ed., National Cancer Institute Monograph No. 4, 129–140, 1960.Google Scholar
  286. Hlbock, O., W. Van Ebbenhorst Tengbergen, and T. G. Van Rijssel: Studies On the development of mammary tumors in dilute-brown Dbab mice without the agent. J. nat. Cancer Inst. 13, 505–531 (1952).PubMedGoogle Scholar
  287. Murphy, J. B.: The effect of castration, theelin and testosterone on the incidence of leukemia in a Rockefeller Institute strain of mice. Cancer Res. 4, 622–624 (1944).Google Scholar
  288. Murphy, J. B., and E. Sturm: The effect of diethylstilbestrol on the incidence of leukemia in male mice of the Rockefeller Institute Leukemia strain (Ril). Cancer Res. 9, 88–89 (1949). Murray, W. S.: Ovarian secretion and tumor incidence. Science 66, 600–601 (1927).Google Scholar
  289. Murphy, J. B.: Ovarian secretion and tumor incidence. J. Cancer Res. 12, 18–25 (1928).Google Scholar
  290. Murphy, J. B.: Studies on inheritance of mammary carcinoma in mouse. Concentration of extrachromo- somal factor. Physiological stability of individual. Cancer Res. 1, 123–129 (1941a).Google Scholar
  291. Murphy, J. B.: Studies on effect of foster nursing and its relation to the development of mammary carcinoma in mouse. Cancer Res. 1, 790–792 (1941 b).Google Scholar
  292. Murphy, J. B., and C. C. Little: Chromosomal and extrachromosomal influence in relation to the incidence of mammary tumors in mice. Amer. J. Cancer 37, 536–552 (1939).Google Scholar
  293. Murphy, J. B., and S. G. Warner: Segregation mammary cancer to no mammary cancer in the Marsh albino strain of mice. J. nat. Cancer Inst. 7, 183–188 (1947).Google Scholar
  294. Nagareda, C. S., and H. S. Kaplan: The effect of hypophysectomy and X irradiation on lymphoid organs and on the induction of lymphoid tumors in C57 BI mice. J. nat. Cancer Inst. 16, 139–152 (1955).PubMedGoogle Scholar
  295. Nandi, S.: Role of somatotropin in mammogenesis and lactogenesis in C3H/He Crgl Mice. Science 128, 772–774 (1958).PubMedCrossRefGoogle Scholar
  296. Nandi, S.: Hormonal control of mammogenesis and lactogenesis in the C3H/He Crgl mouse. Univ. Calif. Publ. Zool. 65, 1–128 (1959).Google Scholar
  297. Nandi, S.: Effect of the mammary tumor agent (Mta) and of multiple pregnancies on the responsiveness of C3H mammary tissue to somatotropin-containing hormonal combinations. Proc. Amer. Ass. Cancer Res. 3, 254 (1961 a).Google Scholar
  298. Nandi, S.: Differential responsiveness of A and C311 mouse mammary tissues to somatotropin- containing hormonal combinations. Proc. Soc. exp. Biol. (N. Y.) 108, 1–3 (1961 b).Google Scholar
  299. Nandi, S.: Effect of hormones on the maintenance of hyperplastic alveolar nodules in the mammary glands of various strains of mice. J. nat. Cancer Inst. 27, 187–201 (1961 c). and H. A. Bern: Relation between mammary gland responses to lactogenic hormone combinations and tumor susceptibility in various strains of mice. J. nat. Cancer Inst. 24, 907–931 (1960).Google Scholar
  300. Nandi, S.: Effect of hormones on mammary tumor development from transplanted hyperplasticGoogle Scholar
  301. Nandi, S.: alveolar nodules in hypophysectomized-ovariectomized-adrenalectomized C3 H/Crgl mice. J. nat. Cancer Inst. 27, 173–185 (1961).PubMedGoogle Scholar
  302. Nandi, S.:, and K. B. Deome: Hormonal induction and maintenance of precancerous hyperplastic alveolar nodules in the mammary glands of hypophysectomized female C3H/He Crgl mice. Acta Un. int. Caner. 16, 211–224 (1960 c).Google Scholar
  303. Effect of hormones on growth and neoplastic development of transplanted hyper-plastic alveolar nodules of the mammary glands of C3H/Crgl mice. J. nat. Cancer Inst. 24, 883–905 (1960b).Google Scholar
  304. Nlcon, J. L.: Essai de classification des cancers spontanés de la glande mammaire chèz la souris blanche. Bull. Cancer 25, 1–16 (1936).Google Scholar
  305. Olivi, M., C. Biancifiorie G. Barbieri: Il carcinoma spontaneo della mammella del topo ad alta incidenza. Introduzione nello schema classificativo del carcinoma tipo M (mucoso). Lay. Ist. Anat. Univ. Perugia 15, 5–33 (1955).Google Scholar
  306. Olivi, M.,,e F. Caschera: Modificazioni mammarie nel topo sottoposto a pennellature di metil-Google Scholar
  307. Olivi, M.:colantrene (in vergini del Balb/c/Cb/Se substrain). Lay. Ist. Anat. Univ. Perugia 20, 199–211 (1960).Google Scholar
  308. Olivi, M., e G. Barbieri: La fase precancerosa biologica e la genesi dei noduli iperplastici alveolari nella mammella del topo (Riii/Dm/Se substrain). Lay. Ist. Anat. Univ. Perugia 18, 5–24 (1958a).Google Scholar
  309. Olivi, M., e G. Barbieri: Mammary cancer development in the Riii/Dm/Se substrain of mice studied by the histological and “whole mount” methods. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 617–626, L. Severi ed., Division of Cancer Research, Perugia, 1958b.Google Scholar
  310. Olivi, M., e E. Bucciarelli: Contributo alla conoscenza della patogenesi dei noduli di iperplasia alveolare nella mammella del topo (Riii/Dm/Se e Balb/cf/Cb/Se substrains). Lay. Ist. Anat. Univ. Perugia 21, 107–117 (1961).Google Scholar
  311. Olivi, M., E. G. Consolandi: Rilievi sul cancro estrogenico della mammella nel topo “h.m.c.”. Lay. Ist. Anat. Univ. Perugia 15, 241–270 (1955).Google Scholar
  312. Orr, J. W.: The chemical induction of mammary and ovarian tumours. Acta Un. int. Caner. 12, 682–689 (1956).Google Scholar
  313. Passaretti, J. R., e F. Cascrera• Il ciclo estrale nei topi femmina vergini del ceppo C+. Lay. Ist. Anat. Univ. Perugia 16, 169–175 (1956).Google Scholar
  314. Passey, R. D., L. Dmochowski, W. T. Astbury, and R. Reed: Electron microscope studies of normal and malignant tissues of high-and low-breast-cancer strains of mice. Nature (Lond.) 160, 565 (1947).CrossRefGoogle Scholar
  315. Passey, R. D.,and P. Johnson: Ultracentrifugation and electron microscope studies of tissuesGoogle Scholar
  316. Passey, R. D.::of inbred strains of mice. Nature (Lond.) 161, 759 (1948). Electron microscope studies of normal and malignant tissues of high-and low-breast-cancer strains of mice. Nature (Lond.) 165, 107 (1950a).CrossRefGoogle Scholar
  317. Passey, R. D., R. Reed, and W. T. Astbury: Biophysical studies of extracts of tissues of high-and low-breast-cancer strain of mice. Biochim. Biophys. Acta 4, 391–409 (1950b).CrossRefGoogle Scholar
  318. Peacock, A.: A possible mode of transmission of the mouse mammary tumor agent by the male parent. Brit. J. Cancer 7, 352–357 (1953).PubMedCrossRefGoogle Scholar
  319. Pikovski, M. A.: The survival of the mammary tumor agent in cultures of heterologous cells. J. nat. Cancer Inst. 13, 1275–1282 (1953).PubMedGoogle Scholar
  320. Pitelka, D. R., H. A. Bern, K. B. Deome, C. N. Schooley, and S. R. Wellings: Virus-like particles in hyperplastic alveolar nodules of the mammary gland of the C3 H/HeCrgl mouse. J. nat. Cancer Inst. 20, 541–553 (1958).PubMedGoogle Scholar
  321. Pitelka, D. R., K. B. Deome, and H. A. Bern: Viruslike particles in precancerous hyperplastic mammary tissues of C3H and C3Hf mice. J. nat. Cancer Inst. 25, 753–777 (1960).Google Scholar
  322. Porter, K. R., and H. P. Thompson: A particulate body associated with epithelial cells cultured from mammary carcinomas of mice of a milk-factor strain. J. exp. Med. 88, 15–24 (1948).PubMedCrossRefGoogle Scholar
  323. Prehn, R. T.: Transfer of the mammary tumor milk agent from implant to host. J. nat. Cancer Inst. 12, 1127–1139 (1952).PubMedGoogle Scholar
  324. Pullinger, B. D.: Cystic disease of the breast human and experimental. Lancet 16, 567–572 (1947).CrossRefGoogle Scholar
  325. Pullinger, B. D.: Tests for mammary tumour agent in C3Hf and Riiif mouse strains. Brit. J. Cancer 14, 279–284 (1960).PubMedCrossRefGoogle Scholar
  326. Pullinger, B. D.:, and S. Iversen: Mammary tumour incidence in relation to age and number of litters in C3Hf and Riiif mice. Brit. J. Cancer 14, 267–278 (1960).PubMedCrossRefGoogle Scholar
  327. Pybus, F. C., and E. W. Miller: A sex difference in the incidence of bone tumors in mice. Amer. J. Cancer 34, 248–251 (1938).Google Scholar
  328. Pybus, F. C., and E. W. Miller: The gross pathology of spontaneous bone tumors in mice. Amer. J. Cancer 40, 47–53 (1940).CrossRefGoogle Scholar
  329. Ranadive, J. K.: The influence of “milk borne tumor agent” on some endocrine glands in intact and castrated mice. Acta Un. int. Caner. 12, 701–710 (1956).Google Scholar
  330. Rauscher, F. J.: A virus-induced disease of mice characterized by erythrocytopoiesis and lymphoid leukemia. J. nat. Cancer Inst. 29, 515–543 (1962).PubMedGoogle Scholar
  331. Richardson, F. L., and G. Hall Mammary tumors and mammary-gland development in hybrid mice treated with diethylstilbestrol for varying periods. J. nat. Cancer Inst. 25, 1023–1033 (1960).PubMedGoogle Scholar
  332. Richardson, F. L., and K. P. Hummel: Mammary tumors and mammary-gland development in virgin mice of strains C3H, Riii and their Fl hybrids. J. nat. Cancer Inst. 23, 91–100 (1959).PubMedGoogle Scholar
  333. Samuels, L. T., J. J. Bittner, and B. K. Samuels: Excretion of steroids in the feces of mice of various strains with and without the mammary tumor milk agent. Cancer Res. 7, 722 (1947).Google Scholar
  334. Severi, L., C. Bianicfiori, M. Olivi, and F. Squartini: On hormone dependence in the transmission of mammary tumour agent from males. In: Endocrine Aspects of Breast Cancer, pp. 283–290, A. R. Currie ed., London: E. and S. Livingstone Ltd. 1958.Google Scholar
  335. Severi, L., C. Bianicfiori, M. Olivi, and F. Squartini: A microscopical study of mammary cancer in hybrid mice, with particular reference to histogenesis. Acta Un. int. Caner. 15, 227–231 (1959).Google Scholar
  336. M. Olivie C. Biancifiori: Istopatologia del carcinoma mammario negli “inbred strains” del topo. Atti Soc. ital. Cancer. 1, 85–158 (1958).Google Scholar
  337. M. Olivi, and F. Squartini: A parallel study of human and experimental breast cancer. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 835–845, L. Severi ed., Division of Cancer Research, Perugia, 1958.Google Scholar
  338. M. Olivi: Discussion of the Mühlbock’s paper. In: A Ciba Foundation Symposium on Carcinogenesis, Mechanisms of Action, p. 94, G. E. W. Wolstenholme and M. O’CoNNoR eds., London: J. and A. Churchill Ltd. 1959.Google Scholar
  339. M. Olivi: Problems arising in the control of breast cancer. Acta Un. int. Caner. 18, 755 759 (1962).Google Scholar
  340. Shimxin, M. B.: Unpublished data, 1943. Quoted by M. B. ShiuKin, 1945.Google Scholar
  341. Shimxin, M. B.: Hormones and mammary cancer in mice. In: A Symposium on Mammary Tumors in Mice, pp. 85–122, F. R. Moulton ed., American Association for the Advancement of Science, Washington, 1945.Google Scholar
  342. Shimxin, M. B., and H. B. Andervont: Effect of foster nursing on the response of mice to estrogens. J. nat. Cancer Inst. 1, 599–605 (1941).Google Scholar
  343. Shimxin, M. B., and H. B. Andervont: Effect of foster nursing on the induction of mammary and testicular tumors in mice injected with stilbestrol. J. nat. Cancer. Inst. 2, 611–622 (1942).Google Scholar
  344. Silberberg, M., and R. Silberberg: Susceptibility to estrogen of breast, vagina, and endometrium of various strains of mice. Proc. Soc. exp. Biol. (N. Y.) 76, 161–164 (1951).CrossRefGoogle Scholar
  345. Silberberg, M., and R. Silberberg: Leukemogenic action of adrenocorticotrophic hormone (Acth) in mice of various ages. Cancer Res. 15, 291–293 (1955).PubMedGoogle Scholar
  346. Silberberg, R., M. Silberberg, and J. J. Bittner: Relative rôle of milk agent and tissue sensitivity in estrogen induced mammary growth. Proc. Soc. exp. Biol. (N. Y.) 77, 473–477 (1951).CrossRefGoogle Scholar
  347. Sinkovics, J. G., C. C. Shullenberger, and D. H. Clifton: Comparative studies on leukemogenesis in mice inoculated with murine and human leukemic materials. In: Atti di un Simposio Internazionale su I Virus nelle Leucemie dei Mammiferi, pp. 171–188, Accademia Nazionale dei Lincei, Roma, 1964.Google Scholar
  348. Slye, M., H. F. Holmes, and H. G. Wells • Primary spontaneous tumors of the ovary in mice. J. Cancer Res. 5, 205–226 (1920).Google Scholar
  349. Smith, F. W.: Castration effects of inherited hormonal influence. Science 101, 279–281 (1945).PubMedCrossRefGoogle Scholar
  350. Smith, F. W.: Castration effects on the inherited hormonal influence. Cancer Res. 6, 494 (1946).Google Scholar
  351. Smith, F. W.: Relationships of the inherited hormonal influence to the production of adrenal cortical tumors by castration. Cancer Res. 8, 641–651 (1948).PubMedGoogle Scholar
  352. Smith, F. W., and J. J. Bittner: Castration effects in relation to inherited hormonal influence in mice. Cancer Res. 5, 588 (1945).Google Scholar
  353. Smoller, C. G., D. R. Pitelka, and H. A. Bern: Cytoplasmic inclusion bodies in cortisol-treated mammary tumors of C3H/Crgl mice. J. biophys. biochem. Cytol. 9, 915–920 (1961).PubMedCrossRefGoogle Scholar
  354. Squartini, F.: Momenti di applicazione dei fattori eziologici del cancro mammario spontaneo del topo. Lay. Ist. Anat. Univ. Perugia 15, 153–161 (1955).Google Scholar
  355. Squartini, F.: Il significato dell’ “agente” nella risposta iperplastica della mammella del topo a stimoli ormonici. Lay. Ist. Anat. Univ. Perugia 16, 143–167 (1956a).Google Scholar
  356. Squartini, F.: Il significato della suscettibilità ereditaria nella risposta iperplastica della mammella del topo a stimoli ormonici. Lay. Ist. Anat. Univ. Perugia 16, 177–198 (1956b).Google Scholar
  357. Squartini, F.: La patogenesi del cancro spontaneo della mammella del topo. Lay. Ist. Anat. Univ. Perugia 16, 211–269 (1956c).Google Scholar
  358. Squartini, F.: A new method for the study of the mammary gland of the mouse: Surface area of the glandular tree in section. Cancer 10, 179–182 (1957).PubMedCrossRefGoogle Scholar
  359. Squartini, F.: Eziopatogenesi del carcinoma mammario negli “inbred strains” del topo. Atti Soc. ital. Cancer. 1, 7–84 (1958).Google Scholar
  360. Squartini, F.: Mammogenesis and breast carcinogenesis in virgin female mice of Balb/cf substrain with the milk agent. J. nat. Cancer Inst. 23, 1227–1238 (1959).PubMedGoogle Scholar
  361. Squartini, F.: Mammary tumors in mice as a model in studies on carcinogenesis. In: Recent Contributions to Cancer Research in Italy, Vol. 1, pp. 289 335, P. Bucalossi and U. Veronesi eds., Casa Editrice Ambrosiana, Milano, 1960.Google Scholar
  362. Squartini, F.: Strain differences in growth of mouse mammary tumors. J. nat. Cancer Inst. 26, 813–828 (1961).Google Scholar
  363. Squartini, F.: Responsiveness and progression of mammary tumors in high-cancer-strain mice. J. nat. Cancer Inst. 28, 911–926 (1962a).PubMedGoogle Scholar
  364. Squartini, F.: Progress Report to Usphs Research Grant C-3844 Path: “A study of mammary cancer”. Lay. Ist. Anat. Univ. Perugia 22, 97–145 (1962b).Google Scholar
  365. Squartini, F.: E. Barola, I. Paoletti, e G. Rossi: Gravidico-dipendenza dei tumori mammari nei topi del C3H/Cb/Se substrain. Lay. Ist. Anat. Univ. Perugia 24, 29–37 (1964).Google Scholar
  366. Squartini, F., e C. Biancifiori: Comportamento del “mammary tumor agent” dopo introduzione nell’ospite suscettibile. Lay. Ist. Anat. Univ. Perugia 18, 119–123 (1958).Google Scholar
  367. Squartini, F., C. BoLli, and G. Rossi: On the factors controlling breast susceptibility to estradiolbenzoate in mice. In: Proceedings of the II International Symposium on Mammary Cancer, pp. 523–538, L. Severi ed., Division of Cancer Research, Perugia, 1958. e F. Caschera: Sviluppo mammario, noduli di iperplasia alveolare e tumori nei topi femmina vergini Balb/cf. Lay. Ist. Anat. Univ. Perugia 18, 175–204 (1958).Google Scholar
  368. Squartini, F., e G. Lotti: Morfologia e funzione delle strutture mammarie del topo (con riferimenti alla mammella umana). Lay. Ist. Anat. Univ. Perugia 15, 61–76 (1955).Google Scholar
  369. Squartini, F., e R. R.Bacchi: Irregolarità nella propagazione del “mammary tumor agent” attraverso i topi Riii. Lay. Ist. Anat. Univ. Perugia 20, 5–16 (1960).Google Scholar
  370. Squartini, F., e G. Rossi: Accrescimento e progressione dei tumori mammari nei topi femmina del substrain Riii/Dm/Se. Lay. Ist. Anat. Univ. Perugia 19, 105–124 (1959a).Google Scholar
  371. Squartini, F.: Analisi morfologica della “responsiveness” e della progressione nei tumori mammari del “substrain” Riii/Dm/Se. Lay. 1st. Anat. Univ. Perugia 19, 165–214 (1959b).Google Scholar
  372. Squartini, F.: Studio dei tumori mammari nel Balb/cf/Cb/Se substrain: accrescimento “responsiveness” e progressione, origine istologica, morfologia. Lay. Ist. Anat. Univ. Perugia 20, 133–165 (1960).Google Scholar
  373. Squartini, F.: Cancerogenesi e caratteri dei tumori mammari nei topi (Riii/Dm/Se substrain) sottoposti ad una singola gravidanza. Lay. Ist. Anat. Univ. Perugia 21. 53–68 (1961 a).Google Scholar
  374. Squartini, F.: Comportamento dei tumori mammari nei topi (Riii/Dm/Se substrain) accoppiati con maschi vasectomizzati. Lay. Ist. Anat. Univ. Perugia 21, 119–137 (1961 b).Google Scholar
  375. Squartini, F.: Responsiveness and progression of the morphological precursors of breast cancer in inbred mice: A review. In: The Morphological Precursors of Cancer, pp. 319–327, L. Severi ed., Division of Cancer Research, Perugia, 1962.Google Scholar
  376. Squartini, F.: Alta incidenza di leucemia nei topi Balb/c allattati da Riii. In: Atti di un Simposio Internazionale su I Virus nelle Leucemie dei Mammiferi, pp. 129–148, Accademia Na_ zionale dei Lincei, Roma, 1964a.Google Scholar
  377. Squartini, F.: Unpublished data, 1964 b.Google Scholar
  378. Squartini, F., N. Maltzeffe O. Sacco: Influenza del “forced breeding” sulla “responsiveness” dei tumori mammari (Riii/Dm/Se substrain). Lay. Ist. Anat. Univ. Perugia 20. 237–251 (1960).Google Scholar
  379. Squartini, F.:,e I. Paoletti: Trasmissione extracromosomica dei caratteri tumorali: effetto del “foster-nursing” sul comportamento biologico e morfologico dei tumori mammari del topo. Lay. Ist. Anat. Univ. Perugia 22, 203–211 (1962a). Tumori 48, 273 (1962b).Google Scholar
  380. Squartini, F.:,e I. Paoletti: Characters of mammary tumours in Balb/c female mice foster-nursed by C 3H and Riii mothers. Nature (Lond.) 197, 505–506 (1963).CrossRefGoogle Scholar
  381. Squartini, F., and L. Severi: Strain differences in the mammary tumour-inducing virus as detected by the characters and behaviour of neoplasms. In: A Ciba Foundation Symposium on Tumour Viruses of Murine Origin, pp. 82–106, G. E. W. WolstexxOlme and M. O’Connor eds., London: J. and A. Churchill Ltd. 1962.Google Scholar
  382. Squartini, F.: Analisi statistica dei fattori che influenzano la trasmissione del “mammary tumour virus” da parte del maschio. In: La Statistica nelle Ricerche sui Tumori, Proceedings of a Symposium held in Rome, Oct. 27–28, 1963 (in press).Google Scholar
  383. Staff of the Roscoe B. Jackson Memorial Laboratory: The existence of nonchromosomal influence in the incidence of mammary tumors in mice. Science 78, 465–466 (1933).Google Scholar
  384. Stewart, H. L.: Experimental cancer of the alimentary tract. In: The Physiopathology of Cancer, pp. 3–45, F. Homburger and W. H. Fishman eds., London: Cassell and Company Ltd. 1953a.Google Scholar
  385. Stewart, H. L.: Endometrial cancer of the rabbit. In: The Physiopathology of Cancer, pp. 165–170, F. Homburger and W. H. Fishman eds., London: Cassell and Company Ltd. 1953 b.Google Scholar
  386. Stewart, H. L.: Pulmonary tumors in mice. In: The Physiopathology of Cancer, 2nd edition, pp. 18–37, F. Homburger ed.. London: Cassell and Company Ltd. 1958.Google Scholar
  387. Stone, R., and D. H. Moore: Purification of the mouse mammary carcinoma agent by means of a fluorocarbon. Nature (Lond.) 183, 1275–1276 (1959).CrossRefGoogle Scholar
  388. Strong, L. C.: Latent period in growth of spontaneous mammary carcinoma in female mice of the A strain. Arch. Path. 26, 814–819 (1938).Google Scholar
  389. Suzuki, T.: Electron microscopic cyto-histopathology. Iii. Electron microscopic studies on spontaneous mammary carcinoma of mice. Gann 48, 39–56 (1957).Google Scholar
  390. Tannenbaum, A.: The dependence of tumor formation on the degree of caloric restriction. Cancer Res. 5, 609–615 (1945 a).Google Scholar
  391. Tannenbaum, A.: The dependence of tumor formation on the composition of the caloric-restricted diet as well as on the degree of restriction. Cancer Res. 5, 616–625 (1945b).Google Scholar
  392. Tannenbaum, A., and H. Silverstone: The genesis and growth of tumors. IV. Effects of varying the proportion of protein (casein) in the diet. Cancer Res. 9, 162–173 (1949a).PubMedGoogle Scholar
  393. Tannenbaum, A., and H. Silverstone: Dependence of formation of spontaneous mammary carcinoma in mice on the proportion of dietary fat. Cancer Res. 9, 607–608 (1949b).Google Scholar
  394. Tannenbaum, A., and H. Silverstone: Nutrition in relation to cancer. Advanc. Cancer Res. 1, 451–501 (1953). Taylor, A., N. Carmichael, and T. Norris: Further report on yolk sac cultivation of tumor tissue. Cancer Res. 8, 264–269 (1948).Google Scholar
  395. Tannenbaum, A., R. E. Hungate, and D. R. Taylor: Yolk sac cultivation of tumors. Cancer Res. 3, 537–541 (1943).Google Scholar
  396. Tannenbaum, A., J. Tracker, and D. Pennington: The growth of cancer tissue in the yolk sac of the chick embryo. Science 96, 342–343 (1942).CrossRefGoogle Scholar
  397. References 73Google Scholar
  398. Taylor, H. C., and C. A. Waltman: Hyperplasias of the mammary gland in the human being and in the mouse. Arch. Surg. 40, 733–820 (1940).CrossRefGoogle Scholar
  399. Thung, P. J., L. M. BooT, and O. MÜHlbock: Senile changes in the oestrous cycle and in ovarian structure in some inbred strains of mice. Acta Endocr. (Kbh.) 23, 8–32 (1956).PubMedGoogle Scholar
  400. Trentin, J. J.: Vaginal sensitivity to estrogens as related to mammary tumor incidence in mice. Cancer Res. 10, 580–583 (1950).PubMedGoogle Scholar
  401. Trentin, J. J.: The effect of the presence or absence of the milk factor and of castration on mammary response to estrogen in male mice of strains of known mammary tumor incidence. Cancer Res. 11, 286–287 (1951).Google Scholar
  402. Trentin, J. J.: Unpublished data, 1953. Quoted by W. U. Gardner et al., 1953.Google Scholar
  403. Trentin, J. J., and C. W. Turner: Quantitative study of the effect of inanition on responsiveness of the mammary gland to estrogens. Endocrinology 29, 984–989 (1941).CrossRefGoogle Scholar
  404. Turner, C. W. and E. T. Gomez: The normal development of the mammary gland of the male and female albino mouse. II. Extrauterine. Mo. Agr. exp. Sta. Res. Bull. 182, 21–43 (1933).Google Scholar
  405. Twombly, G. H., and H. C. Taylor: Inactivation and conversion of estrogens in vitro by liver and other tissues from human cancer patients and from mice of strains susceptible to mammary carcinoma. Cancer Res. 2, 811–817 (1942).Google Scholar
  406. Upton, A. C., and J. Furth: The effects of cortisone on the development of spontaneous leukemia in mice and on its induction by irradiation. Blood 9, 686–695 (1954).PubMedGoogle Scholar
  407. Visscher, M. B., R. G. Green, J. J. Bittner, Z. B. Ball, and H. A. Siedentopf: Charac-terization of milk influence in spontaneous mammary carcinoma. Proc. Soc. exp. Biol. (N. Y.) 49, 94–96 (1942).CrossRefGoogle Scholar
  408. Vogt, M., and R. Dulbecco: Studies on cells rendered neoplastic by polyoma virus: The problem of the presence of virus-related materials. Virology 16, 41–51 (1962).PubMedCrossRefGoogle Scholar
  409. Wallace, E. W., H. Wallace, and C. A. Mills: Influence of environmental temperature upon the incidence and course of spontaneous tumors in C 3H mice. Cancer Res. 4, 279–281 (1944).Google Scholar
  410. Wallace, E. W., H. Wallace: Influence of environmental temperature upon the incidence and course of spon- taneous tumors in spayed C3H mice. Cancer Res. 5, 47–48 (1945).Google Scholar
  411. White, F. R., and J. White: Effect of a low-lysine diet on mammary-tumor formation in strain C3H mice. J. nat. Cancer Inst. 4, 41–42 (1944).Google Scholar
  412. White, F. R., and J. White, G. B. Mider, M. G. Kelly, and W. E. Heston: Effect of caloric restriction on mammary-tumor formation in strain C3H mice and on the response of strain Dba to painting with methylcholanthrene. J. nat. Cancer Inst. 5, 43–48 (1944).Google Scholar
  413. White, J., and G. B. Mider: Effect of certain dietary constituents on the incidence of leukemia produced by methylcholanthrene in dilute brown mice. Cancer Res. 3, 129–130 (1943).Google Scholar
  414. Woolley, G. W., E. Fekete, and C. C. Little: Mammary tumor development in mice ovariectomized at birth. Proc. nat. Acad. Sci. 25, 277–279 (1939).CrossRefGoogle Scholar
  415. Woolley, G. W., E. Fekete, and C. C. Little: Differences between high and low breast tumor strains of mice when ovariectomized at birth. Proc. Soc. exp. Biol. (N. Y.) 45, 796–798 (1940). Gonadectomy and adrenal neoplasms. Science 97, 291 (1941a).Google Scholar
  416. Woolley, G. W., E. Fekete, and C. C. Little: Effects of castration in the dilute brown strain of mice. Endocrinology 28, 341–343 (1941 b).Google Scholar
  417. Woolley, G. W., L. W. Law, and C. C. Little: The occurrence on whole blood of material influencing the incidence of mammary carcinoma in mice. Cancer Res. 1, 955–956 (1941).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1966

Authors and Affiliations

  • Francesco Squartini

There are no affiliations available

Personalised recommendations