Abstract
Angiogenesis refers to the development of new blood vessels. Such a development can occur as a response to either normal physiological events or abnormal pathological conditions. Examples of normal angiogenic processes include the vascular development which occurs during embryogenesis (Sabin, 1920; Wagner, 1980) and wound healing (Clark and Clark, 1932; Cliff, 1963; Schoefl, 1963). The precisely controlled vascularization which occurs during embryogenesis is crucial to proper fetal development, not only in providing for nutrient and waste exchange within rapidly developing tissues, but also, perhaps, in influencing the development of surrounding tissues (Goudie et al., 1980). Using histological techniques, embryologists have documented the transformation of embryonic mesodermal cells into blood islands and angioblasts (Sabin, 1920; Wagner, 1980). The ability to form new vessels is not lost with the cessation of embryogenesis. Indeed, if influenced by an appropriate stimulus, an angiogenic response can be induced in most post-embryonic vascularized tissues. During the process of wound healing, for example, damaged tissue, including vascular tissue, is either repaired or replaced (Cliff, 1963; Schoefl, 1963). However, unlike the mesodermal-derived vascularization events of early embryogenesis, most neovascularization events of fully developed tissues occur as extensions of nearby, pre-existing blood vessel networks.
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Mello, R.J. (1982). Coordinate Control of Retinal Neovascularization. In: Sheffield, J.B., Hilfer, S.R. (eds) Cellular Communication During Ocular Development. Cell and Developmental Biology of the Eye. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-26557-4_9
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DOI: https://doi.org/10.1007/978-3-662-26557-4_9
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