The Role of Placenta in the Synthesis and Metabolism of Proteins

  • John B. Josimovich

Abstract

The main goal of this review of placental protein metabolism in the primate is to present certain areas of information which, although limited, might serve as a basis for future techniques of diagnosis and therapy of disordered fetal functions. Since our state of knowledge even in narrowly defined areas is quite incomplete, it is hoped that this discussion will designate where more data is readily accessible to newer research techniques. Figure 1 summarizes the five ways in which the primate chorioallantoic placenta affects protein metabolism: synthesis of structural and enzymatic proteins which remain within the placenta, synthesis of protein hormones, transplacental passage of proteins and amino acids, storage, and degradation of proteins.

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References

  1. Beck, P., M. L. Parker, and W. H. Daughaday. Radioimmunologic measurement of human placental lactogen in plasma by a double antibody method during normal and diabetic pregnancy. J. Clin. Endocrinol. 25: 1457, 1965.CrossRefGoogle Scholar
  2. Brody, S. Quantitative studies on nucleic acids and nuclease activities during development of human placenta. Acta Obstet. Gynec. Scandinay. 32 (Suppl. 6): 23, 1953.Google Scholar
  3. Brody, S., and G. Carlstrom. Human chorionic gonadotrophin patterns in serum and its relation to the sex of the fetus. J. Clin. Endocrinol. 25: 792, 1965.CrossRefGoogle Scholar
  4. Brown, W. E., and J. T. Bradbury. Studies of the physiological action of human chorionic hormone. Amer. J. Obst. & Gynec. 53: 749, 1947.Google Scholar
  5. Burt, R. L. Peripheral utilization of glucose in pregnancy. III. Insulin tolerance. Obstet. Gynecol. 7: 658, 1956.Google Scholar
  6. Catt, K. J., B. Moffat, and H. D. Niall. Human growth hormone and placental lactogen: structural similarity. Science 157: 321, 1967.PubMedCrossRefGoogle Scholar
  7. Forsyth, I. A. Prolactin-like activities of human growth hormone and human placental lactogen in vivo and in vitro Int. Symp. on Growth Hormone, Milan, 1967. In press. (Abstr. No. 31, Excerpta Medica, Int. Cong. Series No. 142.)Google Scholar
  8. Freinkel, N., and C. J. Goodner. Carbohydrate metabolism in pregnancy. I. The metabolism of insulin by human placental tissue. J. Clin. Invest. 39: 116, 1960.CrossRefGoogle Scholar
  9. Friesen, H. Purification of a placental factor with immunological and chemical similarity to human growth hormone. Endocrinology 76: 369, 1965.PubMedCrossRefGoogle Scholar
  10. Friesen, H. G. The subcellular distribution and biosynthesis of placental lactogen. Int. Symp. Pharmacol. Hormonal Polypeptides and Proteins, Milan, 1967. In press.Google Scholar
  11. Goodner, C. J., and N. Freinkel. Carbohydrate metabolism in pregnancy: the degradation of insulin by extracts of maternal and fetal structures in the pregnant rat. Endocrinology 65: 957, 1959.CrossRefGoogle Scholar
  12. Goss, D. A. In Comparative Aspects of Reproductive Failure. K. Benirschke, ed., New York: Springer-Verlag, 1967, pp. 175–177.Google Scholar
  13. Got, R., and R. Bourillon. Nouvelles données physiques sur la gonadotropine choriale humaine. Biochem. Biophys. Acta 39: 241, 1960.CrossRefGoogle Scholar
  14. Grumbach, M. M. Growth hormone-like activity of chorionic growth hormoneprolactin (CGP) and its postulated function in pregnancy. Int. Symp. Pharmacol. Hormonal Polypeptides and Proteins, Milan, 1967. In press.Google Scholar
  15. Hayashi, T. T. Studies on placental metabolism. II. Purine nucleotide catabolism in the early placenta. Amer. J. Obst. & Gynec. 93: 266, 1965.Google Scholar
  16. Hayashi, T. T., R. C. Baldridge, P. S. Olmsted, and D. L. Kimmel. Purine nucleotide catabolism in the placenta. Amer. J. Obst. & Gynec. 88: 470, 1964.Google Scholar
  17. Javert, C. T. Spontaneous and Habitual Abortion. New York: The Blakiston Div., McGraw-Hill, 1957.Google Scholar
  18. Josimovich, J. B. In Comparative Aspects of Reproductive Failure. K. Benirschke, ed., New York: Springer-Verlag, 1967, pp. 170 et seq.. “The Human Placental Lactogen,” in Clinical Endocrinology II. E. B. Astwood and C. E. Cassidy, eds., New York: Grune & Stratton, 1968, Ch. VI.Google Scholar
  19. Josimovich, J. B., and B. L. Atwood. Human placental lactogen (HPL), a trophoblastic hormone synergizing with chorionic gonadotropin and potentiating the anabolic effects of pituitary growth hormone. Amer. J. Obst. & Gynec. 88: 867, 1964.Google Scholar
  20. Josimovich, J. B., B. L. Atwood, and D. A. Goss. Luteotrophic, immunologic and electrophoretic properties of human placental lactogen. Endocrinology 73: 410, 1963.PubMedCrossRefGoogle Scholar
  21. Josimovich, J., B., and L. Cato. Unique luteotrophic properties of combinations of human placental lactogen and chorionic gonadotrophin. Fertility and Sterility. B. Westin and N. Wiqvist, eds., Excerpta Medica, Int. Cong. Series No. 133, 1967, p. 502.Google Scholar
  22. Josimovich, J. B., H. Izenson, B. Kosor, L. Wilson, and I. Weliky. Correlation of biological and immunochemical studies on human placental lactogen. Int. Symp. on Growth Hormone, Milan, 1967. In press. (Abstr. No. 12, Excerpta Medica, Int. Cong. Series No. 142.)Google Scholar
  23. Josimovich, J. B., and E. Knobil. Placental transfer of P31-insulin in the Rhesus monkey. Amer. J. Physiol. 200: 471, 1961.PubMedGoogle Scholar
  24. Josimovich, J. B., and J. A. MacLaren. Presence in the human placenta and term serum of a highly lactogenic substance immunologically related to pituitary growth hormone. Endocrinology 71: 209, 1962.PubMedCrossRefGoogle Scholar
  25. Kaplan, S. L., and M. M. Grumbach. Studies of a human and simian placental hormone with growth hormone-like and prolactin-like activities. J. Clin. Endocrinol. 24: 80, 1964.CrossRefGoogle Scholar
  26. Kaplan, S. L., and M. M. Grumbach. Immunoassay for human chorionic “Growth hormone-prolactin” in serum and urne. Science 147: 751, 1965.PubMedCrossRefGoogle Scholar
  27. Kelly, W. T., D. L. Hutchinson, E. A. Friedman, and A. A. Plentl. Placental transmission of tritium and carbon-14 labeled histidine enantiomorphs in primates. Amer. J. Obst. & Gynec. 89: 776, 1964.Google Scholar
  28. Knobil, E. Placental amino acid transport in the Rhesus monkey. Transcript of Third Rochester Trophoblast Conference, U. Rochester, N.Y., 1965.Google Scholar
  29. Midgely, A. R., Jr. Radioimmunoassay: a method of human chorionic gonadotrophin and human luteinizing hormone. Endocrinology 79: 10, 1966.CrossRefGoogle Scholar
  30. Migeon, C. J., J. Bertrand, and C. A. Gemzell. The transplacental passage of various steroid hormones in mid-pregnancy. Rec. Progr. Hormone Res. 17: 207, 1961.Google Scholar
  31. Page, E. W., M. B. Glendening, A. J. Margolis, and H. A. Harper. Transfer of D- and L-Histidine across the human placenta. Amer. J. Obst. & Gynec. 73: 589, 1957.Google Scholar
  32. Plotz, E. J. Endocrine activities of the placenta. Clin. Obstet. & Gynec. 8 (3): 580, 1965.CrossRefGoogle Scholar
  33. Samaan, N., S. C. C. Yen, H. Friesen, and O. H. Pearson. Serum placental lactogen levels during pregnancy in trophoblastic disease. J. Clin. Endocrinol. 26:1303, 1966.Google Scholar
  34. Sciarra, J. J. A placental protein with lactogenic and growth hormone-like properties. Clin. Obstet. Gynec. 10 (1): 132, 1967.Google Scholar
  35. Villee, C. Biochemical evidence of ageing in the placenta. Ciba Fdn. Colloq. Ageing 2: 129, 1956.Google Scholar
  36. Wislocki, G. B. Morphological aspects of ageing in the placenta. Ciba Fdn. Colloq. Ageing 2: 105, 1956.Google Scholar
  37. Zardini, L., P. G. Crosignani, F. Polvani, and M. Panigel. Abstract from 35’’ Réunion de l’Association des Physiologistes, Milan, June 1967.Google Scholar

Copyright information

© Springer Science+Business Media New York 1968

Authors and Affiliations

  • John B. Josimovich

There are no affiliations available

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