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Diagnosis and Treatment of Fetal Disorders pp 151–162Cite as

Maternal-Fetal Acid-Base Relationships

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Abstract

The maintenance of a stable pH is as essential to the fetus as it is to the mother, but the exact manner by which this is achieved is not fully understood. The fetal kidney is unlikely to play an important function in this respect since it is developmentally immature at birth. The placenta is assumed to be the chief regulator of the fetal acid-base status, acting as both lung and kidney to the fetus.

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References

  • Adamsons, K.: Transport of organic substances and oxygen across the placenta. Proceedings of a Symposium on the Placenta, Birth Defects Original Article Series, The National Foundation—March of Dimes 1: 27, 1965.

    Google Scholar 

  • Astrup, P.: A simple electrometric technique for the determination of CO2 tension in blood and plasma, total content of CO2 in plasma, and HCO;2 content in “separated” plasma at a fixed CO2 tension (40 mm.Hg.). Scand. J. Clin. and Lab. Invest. 8: 33, 1957.

    Article  Google Scholar 

  • Bartels, H.: Chemical factors affecting oxygen carriage and transfer from maternal to foetal blood. Symposium on the Oxygen Supply to the Human Foetus. J. Walker and A. C. Turnbull, eds. Oxford: Blackwell, p. 29, 1959.

    Google Scholar 

  • Beard, R. W., E. D. Morris, and S. G. Clayton: pH of foetal capillary blood as an indicator of the condition of the fetus. J. Obstet. Gynaec. Brit. Cw1th. 74: 812, 1967.

    Article  CAS  Google Scholar 

  • Beard, R. W., E. D. Morris, and S. G. Clayton: Foetal blood sampling in clinical obstetrics. J. Obstet. Gynaec. Brit. Cwlth. 73: 562, 1966.

    Article  CAS  Google Scholar 

  • Blechner, J. N., V. G. Stenger, D. V. Eitzman, and H. Prystowsky. Effects of maternal metabolic acidosis on the human fetus and newborn infant. Amer. J. Obstet. Gynec. 99: 46, 1967.

    PubMed  CAS  Google Scholar 

  • Blechner, J. N., G. Meschia, and D. H. Barron. A study of the acid-base balance of fetal sheep and goats. Quart. J. Exper. Physiol. 45: 60, 1960.

    CAS  Google Scholar 

  • Bruns, P. D., R. N. Bernhardt, V. E. Drose, and F. C. Battaglia. Effect of acute maternal metabolic acidosis on the rabbit fetus in utero and its relation to hyaline membrane disease in the newborn. Harper Hosp. Bull. 24: 127, 1966.

    Google Scholar 

  • Campbell, A. G. M., G. S. Dawes, A. P. Fishman, A. I. Hyman, and G. B. James. The oxygen consumption of the placenta and foetal membranes in the sheep. J. Physiol. (Lond.) 82: 439, 1966.

    Google Scholar 

  • Dancis, J., M. Worth, and P. B. Schneidau. Effect of electrolyte disturbances in the pregnant rabbit in the fetus. Amer. J. Physiol. 51: 551, 1957.

    Google Scholar 

  • Daniel, S. S., K. Adamsons, and L. S. James. Lactate and pyruvate as an index of prenatal oxygen deprivation. Pediatrics 37: 942, 1966.

    PubMed  CAS  Google Scholar 

  • Derom, R. De Intrauteriene Hypoxie. Thesis, p. 84. Arscia Uitgaven N. V. Brussels, 1964.

    Google Scholar 

  • Eastman, N. J., and C. M. McClane. The lactic acid content of umbilical cord blood under various conditions. Bull. Johns. Hopkins Hosp. 48: 261, 1931.

    CAS  Google Scholar 

  • Friedman, E. A., M. J. Gray, M. Grynfogel, D. L. Hutchinson, W. T. Kelly, and A. A. Plentl. The distribution and metabolism of C14-labeled lactic acid and bicarbonate in pregnant primates. J. Clin. Inv. 39: 227. 1960.

    Article  CAS  Google Scholar 

  • Goodlin, R. C., and I. H. Kaiser. The effect of ammonium chloride induced maternal metabolic acidosis on the human fetus at term. I. pH, Haemoglobin, Blood Gases, Amer. J. Med. Sci. 233: 662, 1957.

    Article  CAS  Google Scholar 

  • Hendricks, C. H. Studies on lactic acid metabolism in pregnancy and labor. Amer. J. Obstet. Gynec. 73: 492, 1957.

    Google Scholar 

  • James, L. S., I. M. Weisbrot, C. E. Prince, D. A. Holaday, and V. Apgar. The acid base status of human infants in relation to birth asphyxia and the onset of respiration. J. Pediat. 52: 379, 1958.

    Article  PubMed  CAS  Google Scholar 

  • Kubli, F. Fetale Gefahrenzustande und ihr Diagnose. Thesis, p. 49. Georg Thieme, Stuttgart, 1966.

    Google Scholar 

  • Kubli, F., and D. Berg. Acidosis in the human foetus. Symposium on the effect of labour on the fetus. Montevideo—in press, 1964.

    Google Scholar 

  • Low, J. A. Acid-base assessment of the fetus in the normal obstetric patient. Obstet. Gynec. 22: 15, 1963.

    Google Scholar 

  • Lumley, J., P. Renou, W. Newman, and E. C. Wood. Hyperventilation in obstetrics. Amer. J. Obstet. Gynec.—in press, 1967.

    Google Scholar 

  • Meschia, G., J. R. Cotter, C. S. Breathnach, and D. H. Barron. The hemoglobin, oxygen, carbon dioxide and hydrogen ion concentrations in the umbilical bloods of sheep and goats as sampled via indwelling plastic catheters. Quart. J. Exper. Physiol. 50: 185, 1965.

    CAS  Google Scholar 

  • Morishima, H. O. Maternal hyperventilation and fetal acidosis. Bull. Sloane Hosp. 12: 35, 1966.

    Google Scholar 

  • Motoyama, E. K., G. Rivard, F. Acheson, and C. D. Cook. The effect of changes in maternal pH and Pcoz on the Po, of fetal lambs. Anesthesiology 28: 891, 1967.

    Article  PubMed  CAS  Google Scholar 

  • Motoyama, E. K., G. Rivard, F. Acheson, and C. D. Cook. Adverse effect of maternal hyperventilation on the fetus. Lancet 1: 286, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Moya, F., H. O. Morishima, S. M. Shnider, and L. S. James. Influence of maternal hyperventilation on the newborn infant. Amer. J. Obstet. Gynec. 91: 76, 1965.

    CAS  Google Scholar 

  • Newman, W., D. Braid, and C. Wood. Fetal acid-base status. Amer. J. Obstet. Gynec. 97: 43, 1967.

    PubMed  CAS  Google Scholar 

  • Newman, W., P. Mitchell, and C. Wood. Fetal acid-base status. Amer. J. Ob-stet. Gynec. 97: 52, 1967.

    CAS  Google Scholar 

  • Paul, W. M., D. J. Gare, and J. C. Whetham. Assessment of fetal scalp sampling in labor. Amer. J. Obstet. Gynec. 99: 745, 1967.

    PubMed  CAS  Google Scholar 

  • Prowse, C. M., and E. A. Gaensler. Respiratory and acid-base changes during pregnancy. Anesthesiology 26: 381, 1965.

    Article  PubMed  CAS  Google Scholar 

  • Rooth, G. Early detection and prevention of foetal acidosis. Lancet 1: 290, 1964.

    Article  PubMed  CAS  Google Scholar 

  • Rooth, G., and I. Nilsson. Studies on foetal and maternal metabolic acidosis. Clin. Sci. 26: 121, 1964.

    PubMed  CAS  Google Scholar 

  • Rooth, G., and S. Sjostedt, and F. Caligara. Hydrogen concentration, carbon dioxide tension and acid base balance in blood of human umbilical cord and intervillous space of placenta. Arch. Dis. Childh. 36: 278, 1961.

    Article  PubMed  CAS  Google Scholar 

  • Bossier, P. H., and M. Hotz. Respiratorische Funktion und Säure Basengleichgewicht in der Schwangerschaft. Schweiz. med. Wschnschr. 83: 97, 1957.

    Google Scholar 

  • Saling, E. A new method of safeguarding the life of the foetus before and during labour. J. Int. Fed. Gynec. Obstet. 3: 101, 1965.

    Google Scholar 

  • Samueloff, S., Z. Karen, and A. Brzenski. Metabolic changes in acid base balance of the blood during pregnancy, at delivery and post-partium. J. Obstet. Gynaec. Brit. Cwlth. 68: 74, 1961.

    Article  CAS  Google Scholar 

  • Stembera, Z. K., and J. Hodr. Umbilical blood flow in healthy newborn infants during the first minutes after birth. Biol. Neonat. 10: 303, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Vedra, B. Acidosis and anaerobiosis in full term infants. Acta Pediat. 48: 60, 1959.

    CAS  Google Scholar 

  • Weisbrot, I. M., L. S. James, C. E. Prince, D. A. Holaday, and V. Apgar. Acid base homeostasis of the newborn infant during the first 24 hours of life. J. Pediat. 52: 395, 1958.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Richard W. Beard
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Editors and Affiliations

  1. Columbia University, USA

    Karlis Adamsons M.D., Ph.D. (Chairman, Associate Professor of Obstetrics and Gynecology) (Chairman, Associate Professor of Obstetrics and Gynecology)

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© 1968 Springer Science+Business Media New York

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Beard, R.W. (1968). Maternal-Fetal Acid-Base Relationships. In: Adamsons, K. (eds) Diagnosis and Treatment of Fetal Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-26381-5_10

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  • DOI: https://doi.org/10.1007/978-3-662-26381-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-24268-1

  • Online ISBN: 978-3-662-26381-5

  • eBook Packages: Springer Book Archive

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