Abstract
The gross appearance is variable. Lesions may be barely visible or over 1 cm in diameter. They frequently bulge above the surface of the liver capsule, but are sometimes deeply embedded in the liver parenchyma and not visible on the capsular surface. The lesion usually lacks a capsule and has poorly defined borders. Perhaps the greatest variability occurs in the color, usually red, reddish brown, or black with a mottled appearance, while the more cellular and less vascular areas may be white to light tan. Hemangiosarcomas are typically soft and pliable and ooze blood or blood-tinged fluid when sectioned. Cysts are common due either to greatly dilated vascular spaces or to areas of necrosis which subsequently fill with blood (Feron et al. 1981). Rupture of cysts or friable vascular walls results in hemoperitoneum or hemothorax from metastatic lesions in over 75% of rats dying of hemangiosarcoma (Ward et al. 1975).
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Popp, J.A., Cattley, R.C. (1997). Hemangiosarcoma, Liver, Rat. In: Jones, T.C., Popp, J.A., Mohr, U. (eds) Digestive System. Monographs on Pathology of Laboratory Animals, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25996-2_7
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DOI: https://doi.org/10.1007/978-3-662-25996-2_7
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