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Experimental Carcinogenesis, Exocrine Pancreas, Hamster and Rat

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Book cover Digestive System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY,volume 3))

Abstract

Ten years have passed since rodent models of experimental pancreatic carcinogenesis were last reviewed in the first edition of Digestive System in this monograph series. At the time of that review (Scarpelli et al. 1985), it was clear that the exocrine pancreas of rodent species was susceptible to a variety of chemical carcinogens and that these might be models of utility for pathogenetic and other analyses of the carcinogenic process. A remarkable feature of these models is that in various rodent species different types of exocrine cells appear to be susceptible to the neoplastic transformation. For example, in the rat and guinea pig, the majority of tumors induced are acinar cell adenomas and carcinomas, as contrasted to the hamster, in which almost exclusively ductal adenocarcinomas develop. In mice, on the other hand, both acinar cell carcinomas and duct-like carcinomas have been obtained.

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Authors
  1. Dante G. Scarpelli
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Editors and Affiliations

  1. ILSI Research Foundation, Harvard Medical School, 1126 Sixteenth Street. N.W., Washington, DC, 20036, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology, Emeritus) (Professor of Comparative Pathology, Emeritus)

  2. Sanofi Winthrop, Toxicology U.S., Nine Great Valley Parkway, Malvern, PA, 19355, USA

    James A. Popp D.V.M., Ph.D. (International Director of Toxicology, Vice President) (International Director of Toxicology, Vice President)

  3. Medizinische Hochschule Hannover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

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Scarpelli, D.G. (1997). Experimental Carcinogenesis, Exocrine Pancreas, Hamster and Rat. In: Jones, T.C., Popp, J.A., Mohr, U. (eds) Digestive System. Monographs on Pathology of Laboratory Animals, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25996-2_41

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