Abstract
Naturally infected mice have no gross lesions. Tumors arise in many organs, particularly parotid salivary glands, following experimental inoculation of neonatal mice. Submaxillary and sublingual salivary glands, lacrimal glands, and accessory mucous and serous glands of the head and neck are also affected. Salivary tumors are bilateral or unilateral, multilobular, usually well circumscribed, and up to 5 cm in diameter. Small tumors are soft, tan to gray, and bulge on cut surface. Larger tumors can have pseudocystic, mucoid centers and hemorrhage, and they occasionally ulcerate the overlying skin. Other common tumor sites are renal cortex, thymus, mammary gland, skin, subcutis, bone, mesothelium, adrenal gland, and, less commonly, elsewhere. Liver, lung, and pancreas are frequent sites of metastases (Dawe 1979; Stewart 1960). Prior to tumor development, pups are runted with thymic atrophy.
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Barthold, S.W. (1997). Polyoma Virus Infection, Salivary Glands, Mouse. In: Jones, T.C., Popp, J.A., Mohr, U. (eds) Digestive System. Monographs on Pathology of Laboratory Animals, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25996-2_36
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DOI: https://doi.org/10.1007/978-3-662-25996-2_36
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