Hepatocellular Adenoma, Liver, Rat

  • Paul N. Brooks
  • Francis J. C. Roe
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY, volume 3)


Hepatocellular adenomas vary in size and multiplicity. Most are nonfatal and are discovered incidentally when animals are killed or die for other reasons. If a liver tumor is located close to the ventral body wall, it may be detectable by palpation in a nonobese animal. However, this is not a reliable way to detect liver tumors in living animals. Moreover, since heavy palpation may cause a tumor to bleed, this method of detecting liver tumors in living animals is not recommended. If an adenoma arises near the liver surface, it may be noticed at necropsy even if it has a mean diameter of less than 1 mm. Otherwise the presence of small adenomas may not be suspected until tissues are trimmed after fixation or until sections are examined under a microscope. Even the presence of a very large tumor that replaces a whole lobe of the liver may not be suspected until necropsy unless it gives rise to abdominal distension.


Benign liver cell tumor liver parenchymal cell adenoma hepatoma neoplastic nodule 


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  1. Bannasch P (1968) The cytoplasm of hepatocytes during carcinogenesis. II. The ascinus peripheral cytotoxic pattern. A. Light microscopy. B. Electron microscopy. In: Rentchnick P, Herfarth C, Senn HJ (eds) Recent results in cancer research, vol 19. Springer, Berlin Heidelberg New York, pp 18–48Google Scholar
  2. Bannasch P, Bloch M, Zerban H (1981) Spongiosis hepatis. Specific changes of the perisinusoidal liver cells induced in rats by N-nitrosomorpholine. Lab Invest 44:252–264PubMedGoogle Scholar
  3. Frith CH, Ward JM (1980) A morphologic classification of proliferative and neoplastic hepatic lesions in mice. J Environ Pathol Toxicol 3:329–351Google Scholar
  4. Gravela E, Feo F, Canuto RA, Garcea R, Gabriel L (1975) Functional and structural alterations of liver ergastoplasmic membranes during DL-ethionine hepatocarcinogenesis. Cancer Res 35:3041–3047PubMedGoogle Scholar
  5. Hirota N, Williams GM (1979a) The sensitivity and heterogeneity of histochemical markers for altered foci involved in liver carcinogenesis. Am J Pathol 95:317–328PubMedGoogle Scholar
  6. Hirota N, Williams GM (1979b) Persistence and growth of rat liver neoplastic nodules following cessation of carcinogen exposure. J Natl Cancer Inst NCI 63:1257–1265Google Scholar
  7. Kroes R, Williams GM, Weisburger JH (1972) Early appearance of serum alpha-fetoprotein during hepatocarcinogenesis as a function of age of rats and extent of treatment with 3′-methyl-4-dimethylaminoazobenzene. Cancer Res 32:1526–1532PubMedGoogle Scholar
  8. Kuhlmann WD (1978) Localization of alpha 1-fetoprotein and DNA-synthesis in liver cell populations during experimental hepatocarcinogenesis in rats. Int J Cancer 21:368 – 380PubMedCrossRefGoogle Scholar
  9. Marsman DS, Popp JA (1994) Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14,643. Carcinogenesis 15:111–117PubMedCrossRefGoogle Scholar
  10. Reznik-Schüller HM, Gregg M (1983) Sequential morphologic changes during methapyrilene-induced hepatocellular carcinogenesis in rats. J Natl Cancer Inst 71:1021–1031PubMedGoogle Scholar
  11. Schauer A, Kunze E (1976) Tumours of the liver. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol 1. Tumours of the rat, part 2. IARC, Lyon, pp 41–72 (IARC scientific publications no 5)Google Scholar
  12. Shoji Y, Kaneda K, Wake K, Mishima Y (1994) Light and electron microscopic analysis of liver sinusoids during hepatocarcinogenesis with 2-acetylaminofluorene in rats. Jpn J Cancer Res 85:491–498PubMedCrossRefGoogle Scholar
  13. Squire RA, Levitt MH (1975) Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res 35:3214–3223PubMedGoogle Scholar
  14. Stewart HL, Williams GM, Keysser CH, Lombard LS, Montali RJ (1980) Histologic typing of liver tumors of the rat. J Natl Cancer Inst 64:177–206Google Scholar
  15. Sugie S, Yoshimi N, Tanaka T, Mori H, Williams GM (1994) Alterations of nuclear pores in preneoplastic and neoplastic rat liver lesions induced by 2-acetylaminofluorene. Carcinogenesis 15:95–98PubMedCrossRefGoogle Scholar
  16. Tchipysheva TA, Guelstein VI. Bannikov GA (1977) Alpha-fetoprotein-containing cells in the early stages of liver carcinogenesis induced by 3′-methyl-4-dimethyl-aminoazobenzene and 2-acetylaminofluorene. Int J Cancer 20:388–393PubMedCrossRefGoogle Scholar
  17. Williams GM (1980) The pathogenesis of rat liver cancer caused by chemical carcinogens. Biochim Biophys Acta 605:167–189PubMedGoogle Scholar
  18. Williams GM, Watanabe K (1978) Quantitative kinetics of development of N-2-fluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen. J Natl Cancer Inst 61:113–121PubMedGoogle Scholar
  19. Williams GM, Yamamoto RS (1972) Absence of stainable iron from preneoplastic and neoplastic lesions in rat liver with 8-hydroxyquinoline-induced siderosis. J Natl Cancer Inst 49:685–692PubMedGoogle Scholar
  20. Williams GM, Klaiber M, Parker SE, Farber E (1976) Nature of early appearing carcinogen-induced liver lesions resistant to iron accumulation. J Natl Cancer Inst 57:157–165PubMedGoogle Scholar
  21. Williams GM, Klaiber M, Farber E (1977) Differences in growth of transplants of liver, liver hyperplastic nodules, and hepatocellular carcinomas in the mammary fat pad. Am J Pathol 89:379–390PubMedGoogle Scholar
  22. Williams GM, Gebhardt R, Sirma H, Stenbäck F (1993) Non-linearity of neoplastic conversion induced in the rat liver by low exposures to diethylnitrosamine. Carcinogenesis 14:2149–2156PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Paul N. Brooks
  • Francis J. C. Roe

There are no affiliations available

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