Mousepox, Liver, Mouse
The liver is a major site of viral replication in mousepox, but gross lesions, even during acute disease, are not readily apparent until shortly before death. Severely affected livers are usually swollen and friable and may occupy up to half the volume of the peritoneal cavity, whereas mildly affected livers may remain grossly normal or have sparse focal necrosis. Necrotic areas appear first as pinpoint yellow-white foci, but increase rapidly in size and number. Confluent areas of necrosis can produce a reticulated pattern of yellow-brown to pink discoloration on the surface and throughout the parenchyma. Areas of hemorrhage also may develop. The pale hue of severely affected livers is in part due to fatty change, and the fat content of such livers can be as much as four times normal. Livers from mice that survive acute infection usually have a normal gross appearance.
Unable to display preview. Download preview PDF.
- Bhatt PN, Jacoby RO (1985) The pathogenesis of mousepox in genetically resistant and genetically susceptible inbred mice (in preparation)Google Scholar
- De Burgh PM (1950) Cytochemical changes in early ectromelia infection of mice. Aust J Exp Biol 28:214–218Google Scholar
- Fenner F (1982) Mousepox. In: Foster HL, Small JD, Fox JG (eds) The mouse in biomedical research, vol II, diseases. Academic, New York, chap 11Google Scholar
- Kameyama S, Takahashi M, Toyoshima K, Kato S, Kamahora J (1959) Studies on the inclusion bodies of ectromelia virus using the fluorescent antibody technique. Biken J 2:341–344Google Scholar
- Wylekshanin AJ (1935) Transplancental transmission of the filterable virus of infectious ectromelia. Z Ihikrobiol (Moscow) 15:433Google Scholar