K Virus Infection, Mouse
Gross pathologic changes associated with K virus infection are confined to the lungs and are most prominent in mice less than 8 days of age, in whom K virus produces a fatal interstitial pneumonia (Fisher and Kilham 1953; Holt 1959; Greenlee 1979, 1981); lungs of these fatally infected animals are congested and edematous on cut section. In older suckling animals, similar changes of lesser severity are present during the acute stages of infection (Fisher and Kilham 1953; Greenlee 1981). Gross changes are not evident in lungs of immunologically normal weanling or adult mice during acute K virus infection and do not occur during K virus infection in nude (nu/nu) mice or in reactivated K virus infection under conditions of immunosuppression (Fisher and Kilham 1953; Greenlee 1981, 1986; Greenlee and Dodd 1984).
SynonymsNone. However K virus is also referred to as K papovavirus
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- Fisher ER, Kilham L (1953) Pathology of a pneumotropic virus recovered from C3H mice carrying the Bittner milk agent. Arch Pathol 55:14–19Google Scholar
- Greenlee JE (1983) Pathogenesis of K virus infection in mice. In: Sever JL, Madden DL (eds) Polyomaviruses and human neurological disease. Liss, New York, pp 325–342Google Scholar
- Houff SA, Major EO, Katz DA, Kufta CV, Sever JL, Pittaluga S, Roberts JR, Gitt J, Saini N, Lux W (1988) Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy. N Engl J Med 318:301–305PubMedCrossRefGoogle Scholar
- Parker JC, Tennant RW, Ward TG (1966) Prevalence of K virus in mouse colonies. In: Holdenried R (ed) Viruses of laboratory rodents. Natl Cancer Inst Monogr 20:33Google Scholar
- Tennant RW, Parker JC, Ward TG (1966) Respiratory virus infections of mice: K virus. In: Holdenried R (ed) Viruses of laboratory rodents. Natl Cancer Inst Monogr 20:100–104Google Scholar