K Virus Infection, Mouse

  • John E. Greenlee
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY, volume 3)


Gross pathologic changes associated with K virus infection are confined to the lungs and are most prominent in mice less than 8 days of age, in whom K virus produces a fatal interstitial pneumonia (Fisher and Kilham 1953; Holt 1959; Greenlee 1979, 1981); lungs of these fatally infected animals are congested and edematous on cut section. In older suckling animals, similar changes of lesser severity are present during the acute stages of infection (Fisher and Kilham 1953; Greenlee 1981). Gross changes are not evident in lungs of immunologically normal weanling or adult mice during acute K virus infection and do not occur during K virus infection in nude (nu/nu) mice or in reactivated K virus infection under conditions of immunosuppression (Fisher and Kilham 1953; Greenlee 1981, 1986; Greenlee and Dodd 1984).


None. However K virus is also referred to as K papovavirus 


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© Springer-Verlag Berlin Heidelberg 1997

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  • John E. Greenlee

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