Chance-Cleland Model for Enzyme-Substrate Interaction
Let us next develop a model of a chemical reaction in which an enzyme E behaves like a catalyst. There is an initial stock of this enzyme available, some of which will be temporarily tied up due to the production of an intermediate substance C. Ultimately, the enzyme is released again in unchanged form as some product P is formed from the substance C. An additional sub-stance active in this process is the substrate S, which is converted into the product P. Think of the substrate S as dextrose and the product P as fructose: the enzyme E mechanically locks onto the substrate molecule, breaks it into a new molecule, fructose, and is released again after the chemical reaction occurred (Spain 1982).
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