Abstract
During the past several years, evidence has accumulated indicating that functionally separate subpopulations of T-lymphocytes are present in various mammalian species; these include suppressor (16), helper (10), and effector (11) T-cells. We recently reported experimental evidence indicating the possibility that at least two different subpopulations of effector cells may exist in the mouse—one capable of causing graft-versus-host (GvH) reactions and the other primarily responsible for antitumor reactions (3,5). Similarly, Fernandes et al. (15) and Kedar and Bonavida (18) reported that separate subpopulations of effector T-cells were responsible for antihost and antitumor reactions. Several investigators have found that in vivo or in vitro immunizations across histocompatibility barriers could result in a large increase in cell-mediated cytotoxicity against a tumor target with little or no increase in GvH reactivity (9, 23, 24). Mage and McHugh (20) were able to separate lymphocytes with antitumor activities from those with antihost activities by incubating the effector cells on monolayers of allogeneic fibroblasts.
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References
Boranie, M. Transient graft versus host reaction in the treatment of leukemia in mice. J. Natl. Cancer Inst., 4: 421, 1968.
Bortin, M. M., Rimm, A. A., Rodey, G. E., Giller, R. H., and Saltzstein, E. C. Prolonged survival in long-passage AKR leukemia using chemotherapy, radiotherapy and adoptive immunotherapy. Cancer Res., 34:1851, 1974.
Bortin, M. M., Rimm, A. A., Rose, W. C., and Saltzstein, E. C. Graft versus leukemia. V. Absence of antileukemic effect using allogeneic H-2 identical immunocompetent cells. Transplantation, 18: 280, 1974.
Bortin, M. M., Rimm, A. A., and Saltzstein, E. C. Graft versus leukemia: Quantification of adoptive immunotherapy in murine leukemia. Science, 179:811, 1973.
Bortin, M. M., Rimm, A. A., Saltzstein, E. C., and Rodey, G. E. Graft versus leukemia. III. Apparent independent antihost and antileukemic activity of transplanted immunocompetent cells. Transplantation, 16:182, 1973.
Bortin, M. M., Rose, W. C., Truitt, R. L., Rimm, A. A., Saltzstein, E. C., and Rodey, G. E. Graft versus leukemia. VI. Adoptive immunotherapy in combination with chemoradiotherapy for spontaneous leukemia-lymphoma in AKR mice. J. Natl. Cancer Inst., 55:1227, 1975.
Bortin, M. M., and Saltzstein, E. C. A modified technique for collection and processing of mouse fetal hematopoietic tissue for production of radiation chimeras. Exp. Hematol., 10:27, 1966.
Bortin, M. M., Truitt, R. L., Rose, W. C., Rimm, A. A., and Saltzstein, E. C. Adoptive immunotherapy of spontaneous leukemia-lymphoma in AKR mice. In Proceedings of the 7th International Congress of the Reticuloendothelial Society. (In press.)
Brunner, K. T., Mariel, J., Rudolf, H., and Chapuis, B. Studies of allograft immunity in mice. I. Induction, development and in vitro assay of cellular immunity. Immunology, 18: 501, 1970.
Cantor, H., and Asofsky, R. Synergy among lymphoid cells mediating the graft-versus-host response. III. Evidence for interaction between two types of thymus derived cells. J. Exp. Med., 135:764, 1972.
Cerrotini, J. C., and Brunner, K. T. Cell-mediated cytotoxicity, allograft rejection and tumor immunity. Adv. Immunol., 18:67, 1974.
Cleton, F. J., Tan, B. L., Meindersma, T. E., van Rood, J. J., Thomas, P., Mellink, J. H., de Vries, M. J., van Putten, L. M., Kenis, Y., and Tagnon, H. Bone marrow transplantation after total-body irradiation: A case history. Exp. Hematol., 14:44, 1967.
Fefer, A. Immunotherapy of primary Moloney sarcoma-virus-induced tumors. Int. J. Cancer, 5: 327, 1970.
Fekete, E., and Kent, E. Transplantable mouse tumors. Transplant. Bull., 2:61, 1955.
Fernandes, G., Yunis, E. J., and Good, R. Depression of cytotoxic T cell subpopulation in mice by hydrocortisone treatment. Clin. Immunol. Immunopathol., 4: 304, 1975.
Gershon, R. K. A disquisition on suppressor T cells. Transplant. Rev., 26:170, 1975.
Glynn, J. P., and Kende, M: Treatment of Moloney virus-induced leukemia with cyclophosphamide and specifically sensitized allogeneic cells. Cancer Res., 31:383, 1971.
Kedar, E., and Bonavida, B. Studies on the induction and expression of T cell-mediated immunity. IV. Non-overlapping populations of alloimmune cytotoxic lymphocytes with specificity for tumor-associated antigens and transplantation antigens. J. Immunol., 115:1301, 1975.
Klein, J. Biology of the Mouse Histocompatibility-2 Complex, p. 211. New York: Springer-Verlag, 1975.
Mage, M. G., and McHugh, L. L. Retention of graft-vs-host activity in nonadherent spleen cells after depletion of cytotoxic activity by incubation on allogeneic target cells. J. Immunol., 111:652,1973.
Mathé, G. Secondary syndrome, a stumbling block in the treatment of leukaemia by whole-body irradiation and transfusion of allogeneic haematopoietic cells. In Diagnosis and Treatment of Acute Radiation Injury, page 191. Geneva: World Health Organization, 1961.
Meier, H., Taylor, B. A., Chen, H. W., Heiniger, H. J., Diwan, B. A., and Cherry, M. Host-gene control of murine C-type RNA tumor virus expression and tumorigenesis: Genotypic programming for single and multiple primary tumors. In Severi, L., ed., Multiple Primary Malignant Tumors, pp. 569–680. Perugia, Monteluce, Italy: Division of Cancer Research, 1975.
Rouse, B. T., and Wagner, H. The in vivo activity of in vitro immunized mouse thymocytes. II. Rejection of skin allografts and graft-vs-host actiity. J. Immunol., 109: 1282, 1972.
Simonsen, M. Graft versus host reactions, their natural history and applicability as tools of research. Prog. Allergy, 6:349, 1962.
Truitt, R. L., Rimm, A. A., Saltzstein, E. C., Rose, W. C, and Bortin, M. M. Graft-versus-leukemia for AKR spontaneous leukemia-lymphoma. Transplant Proc., 8: 569, 1976.
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LeFeber, W.P., Truitt, R.L., Rose, W.C., Bortin, M.M. (1977). Graft-versus-Leukemia, Donor Selection for Adoptive Immunotherapy in Mice. In: Baum, S.J., Ledney, G.D. (eds) Experimental Hematology Today. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25807-1_27
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DOI: https://doi.org/10.1007/978-3-662-25807-1_27
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