Serum Colony Stimulating Factor: A Marker for Graft-versus-Host Disease in Humans

  • J. W. Singer
  • M. C. James
  • E. D. Thomas


Clinical graft-versus-host disease (GvHD) occurs in approximately 70% of patients with successful allogeneic marrow grafts (24). The diagnosis of GvHD is made on the basis of clinical impression with pathologic confirmation of involvement in any of the three target organs—the skin, the liver, or the gut. Clinical and histologic criteria have been proposed for staging GvHD on a scale ranging from + to + + + + (24). The pathologic assessment of mild, early GvHD is often difficult. Histologic changes in skin are minimal, and their interpretation is complicated by alterations produced by cytotoxic drugs and radiation. The patient’s clinical condition often precludes a liver or bowel biopsy. The present study was initiated as an attempt to find an easily measurable marker for GvHD not dependent on target-organ damage.


Aplastic Anemia Mouse Bone Marrow Granulocyte Count Mouse Bone Marrow Cell Idiopathic Interstitial Pneumonia 
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© Springer Science+Business Media New York 1977

Authors and Affiliations

  • J. W. Singer
  • M. C. James
  • E. D. Thomas

There are no affiliations available

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