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Experimental Hematology Today pp 3–10Cite as

The Appearance of the Multipotential Hemopoietic Stem Cell

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Abstract

It is perhaps not too much of an exaggeration to claim that experimental hematology as it flourishes today originated largely from the pioneering attempts to protect lethally radiated animals (1) by shielding of hemopoietic tissues by L. O. Jacobson (9), and (2) by treatment with bone marrow suspensions by E. Lorenz and his collaborators (12). The site chosen for this annual meeting of the International Society for Experimental Hematology is given a special historic significance by the fact that it was 25 years ago that the first publication on this subject by Lorenz appeared from his laboratory at the National Institutes of Health. Lorenz’s discovery marked the beginning of a period which lasted until 1956, during which the protection afforded by hemopoietic cell suspensions was confirmed by many. This soon led to an intensive scientific debate on the mechanism of this protective effect: was it due to a humoral factor produced and provided by the bone marrow—as Lorenz postulated—or to transplantation and subsequent proliferation of hemopoietic cells?

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Authors
  1. D. W. van Bekkum
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Editors and Affiliations

  1. Experimental Hematology Department, Armed Forces Radiobiology Research Institute, Defense Nuclear Agency, 20014, Bethesda, Maryland, USA

    Siegmund J. Baum (Chairman) (Chairman)

  2. Immunology Division, Experimental Hematology Department, Armed Forces Radiobiology Research Institute, Defense Nuclear Agency, 20014, Bethesda, Maryland, USA

    G. David Ledney (Head) (Head)

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© 1977 Springer Science+Business Media New York

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van Bekkum, D.W. (1977). The Appearance of the Multipotential Hemopoietic Stem Cell. In: Baum, S.J., Ledney, G.D. (eds) Experimental Hematology Today. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25807-1_1

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  • DOI: https://doi.org/10.1007/978-3-662-25807-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-90208-9

  • Online ISBN: 978-3-662-25807-1

  • eBook Packages: Springer Book Archive

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