Abstract
In the pathologic states, collectively known as “hemolytic disease of the newborn”, the placenta is an integral component of the reacting system, and often reflects injury shared with the fetus. Hellman and Hertig described the salient features of placentas associated with the hydropic and icteric forms of this disease. Later authors reiterated their observations and pointed out certain features suggestive of pathogenesis (King, Schmidt, Potter, Alvarez, et al.). Just as Hellman and Hertig remarked on the morphologic similarities between these placentas and those associated with congenital syphilis, others have commented on resemblances to less common fetoplacental diseases, which may mimic erythroblastosis fetalis as the latter affects both the fetus and the placenta (Morison, Scott, Burstein et al., Hirszfeld et al., Eng, Callahan, Bain, Hall, Esch, Schubert, Kouvalainen et al., Dussart).
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References
Allan, T. M.: Abo blood groups and Rh iso-immunization. Brit. J. Prey. Soc. Med. 18, 210, 1964.
Allen, F. H. and L. K. Diamond: Erythroblastosis Fetalis, Boston; Little, Brown, and Company, 1958.
Alvarez, H.: Morphology and physiopathology of the human placenta. I. Studies of morphology and development of chorionic villi by phase-contrast microscopy. Obstet. Gynec. 23, 813, 1964.
R. DE Bejar, S. Aladjem, C. A. Santin, M. R. Remedio and Y. S. Blanco: La Placenta humana—aspectos morfologicos y fisiopatologicos. Quarto Congreso Uruguayo de Ginecologia. 1, 190, 1954.
Apley, J., P. A. Colley and I. D. Fraser: Foetal haemorrhage into the maternal Circulation. Lancet 1, 1375, 1961.
Bain, A. D., J. H. Bowie, W. E. Flint, J. K. A. Beverley and C. P. Beattie: Congenital toxoplasmosis simulating haemolytic disease of the newborn. J. Obstet. Gynaec. Brit. Emp. 63, 826, 1956.
Ballantyne, J. W.: The Diseases and Deformities of the Foetus. Oliver and Boyd, Edinburgh, 1892 1895.
Becker, V., and U. Bleyl: Placentazotte bei Schwangerschaftstoxikose und fetaler Erythroblastose. Virchows Arch. Path. Anat. 334, 516, 1961.
Bickenbach, W.: Über die Neugeborenen-Erythroblastose. Arch. Gynäk. 178, 332, 1950.
Bickenbach, W., and F. Kivel: Mikroskopische Untersuchungen an Erythroblastoseplacenten. Archiv Gynaek. 177, 559, 1950.
Birner, W. F.: Neuroblastoma as a cause of antenatal death. Amer. J. Obstet. Gynec. 82, 1388, 1961.
Blair, B. G.: Oliguria caused by the transference of foetal blood into the maternal circulation. J. Obstet. Gynaec. Brit. Commw. 68, 283, 1961.
Burstein, R.: Vascular lesions of the placenta of possible immunogenic origin in erythroblastosis fetalis. Amer. J. Obstet. Gynec. 83, 1062, 1962.
Burstein, R., A. W. Berns, Y. Hirata, H. T. Blumenthal: A comparative histo-and immune-pathological study of the placenta in diabetes mellitus and in erythroblastosis fetalis. Amer. J. Obstet. Gynec. 86, 66, 1963.
Callahan, W. P., W. O. RussEL and M. G. Smith: Human toxoplasmosis. Medicine 25, 343, 1946
Chown, B.: Anemia from bleeding of the fetus into the mother’s circulation. Lancet i, 1213, 1954.
Clarke, C. A., W. T. A. Donohoe, R. B. Mcconnell, J. C. Woodrow, R. Finn, J. R. Krevans, W. Kulke, D. Lehane and P. M. Sheppard: Further experimental studies on the prevention of Rh haemolytic disease. Brit. Med. J. 1, 979, 1963.
Clifford, S. H. and A. T. Hertig: Erythroblastosis of the newborn. New Engl. J. Med. 207, 105, 1932.
Crawford, J. M.: A study of human placental growth with observations on placenta in erythroblastosis foetalis. J. Obstet. Gynaec. Brit. Emp. 66, 885, 1959.
Desai, R. G., E. Mccutcheon, B. Little and S. G. Driscoll: Direct evidence of fetomaternal passage of leucocytes and platelets in man. (In press, 1965). Driscoll, S. G.: The pathology of pregnancy complicated by diabetes mellitus. Med. Clin. N. A. 49, 1053, 1965.
Drogendyk, A. C.: The pathogenesis of foetal hydrops. Gynecologia 156, 129, 1963. Dussart, R.: Attempt at explaining recurring foetoplacental oedema. Bull. Soc. Belge. Gynec. Obstet. 27, 140, 1957.
Eichelbaum, H. R.: Über die Erythroblastose (Hydrops-congenitus) der Neugebore-nen and ihre Beziehung zum Icterus neonatorum. Arch. Gynäk., 119, 149, 1923
Eng, I. I. L.: Alpha-chain thalassemia and hydrops fetalis in Malaya: Report of five cases. Blood 20, 581, 1962.
Eng, I. I. L. and Y. B. Hie: Hydrops foetalis with a fast moving haemoglobin. Brit. Med. J. 2, 1649, 1960.
Esch, P.: Das kongenitale Lungenadenom and seine Beziehung zum Hydrops fetus universalis and Hydramnion acutum. Arch. Gynäk. 133, 32, 1928.
Finn, R., C. A. Clarke, W. T. A. Donohoe, R. B. Mcconnell and P. M. Sheppard: Transplacental passage of red cells in man. Nature 190, 922, 1961.
Finn, R., C. A. Clarke, W. T. A. Donohoe, R. B. Mcconnell, D. Lehane and W. Kulke: Experimental studies in the prevention of Rh hemolytic disease. Brit. Med. J. 1, 1486, 1961.
Finn, R., C. A. Clarke, D. T. Harper, S. A. Stallings and J. R. Krevans: Transplacental hemorrhage. Transfusion 3, 114, 1963.
Fraser, I. D. and A. B. Raper: Observation of compatible and incompatible foetal red cells in the maternal circulation. Brit. Med. J. 22, 303, 1962.
Freda, V. J.: Abo (H) Blood group substances in the human maternal-fetal barrier and amniotic fluid. Amer. J. Obstet. Gynec. 76, 407, 1958.
Gottschalk, W. and D. Abramson: Placental edema and fetal hydrops. Obstet. Gynec. 10, 626, 1957.
Gunson, H. H.: Neonatal anemia due to hemorrhage into the maternal circulation. Pediatrics 20, 3, 1957.
Hall, E. G.: Congenital toxoplasmosis in the newborn. Arch. Dis. Child. 23, 117, 1953.
Hellman, L. M. and A. T. Hertig: Pathological changes in the placenta associated with erythroblastosis of the fetus. Amer. J. Path. 14, 111, 1938.
Hertig, A. T.: The placenta and fetal membranes. Edited by Claude A. Villee. Williams Wilkins Co., 1960.
Hirszfeld, L. and H. Zobrowsel: Connection of placental permeability with group agglutination in mother and fetus. Klin. Wschr. 4, 1152, 1925.
HÖRmann, G.: Placenta and Lues. Arch. Gynäk. 184, 481, 1954.
Hosol, T.: Serological identification of fetal blood in the maternal circulation. Yokahama Med. Bull. 9, 61, 1958.
Jarkowski, T. L., P. Rosenblatt, Woif and B. Pearson: Tissue-fixed antigens of the Rh blood group system in placentae and fetuses; with particular reference to hemolytic disease of the newborn. Int. Acad. Path. Chicago, April 6, 1964. (Abst.) Lab. Invest. 13, 937, 1964.
Javert, C. T. and C. Reiss: The origin and significance of macroscopic intervillous coagulation hematomas (red infarcts) of the human placenta. Surg. Gynec. Obst. 94, 257, 1952.
King, D.: Placental findings associated with erythroblastosis fetalis. West. J. Surg. 59, 192, 1951.
Kline, B. S.: Microscopic observations of the placental barrier in transplacental erythrocytotoxic anemia (erythroblastosis fetalis) and in normal pregnancy. Amer. J. Obstet. Gynec. 56, 226, 1948.
Kline, B. S.: The pathogenesis of erythroblastosis fetalis. Blood 4, 1249, 1949.
Knox, E. C., S. Murray and W. Walker: The mechanism of Rhesus isoimmunization. J. Obstet. Gynaec. Brit. Commwlth. 68, 11, 1961.
Knox, G. and W. Walker: Nature of the determinants of Rhesus isoimmunization. Brit. J. Prey. Soc. Med. 11, 126, 1957.
KouvarAinen, K., L. Hjelt and N. Hallman: Placenta in congenital nephrotic syndrome. Annales Paed. Fenn. 8, 181, 1962.
Kovacs, Franz: Über die angeborene allgemeine Wassersucht der Frucht an der Hand eines Falles. Zentralbl. Gynäk, 54, 1948, 1930.
Levine, P.: The influence of the Abo system on Rh hemolytic disease. Hum. Biol. 30, 14, 1958.
Maqueo, M. T.: Personal communication.
Martius, G.: Die Pathogenese des Morbus Haemolyticus Neonatorum. Habil.-Schr. Stuttgart: Georg Thieme, 1956.
Mckay, D. G.: Quoted by White, P. In Joslin, E. P., H. H. Root, P. White and A. Marble (eds.): Treatment of Diabetes Mellitus, 10th ed. Philadelphia, Lea and Febiger, 1959, p. 697.
Mckay, D. G., A. T. Hertig, E. C. Adams and M. V. Richardson: Histochemical observations on the human placenta. Obstet. Gynec. 12, 1, 1958.
Mayer, M. M., H. Anh J. Nguyen and M. M. Panigel: Observation au microscope électronique du passage d’hématies ä travers la paroi des capillaries foetaux dans le placenta humain. Compt. Rend. Acad. Sc. (Paris) 260, 4605, 1965.
Morison, J. E.: Foetal and Neonatal Pathology. Second edition. Washington, D. C., Butterworth’s 1963.
Motulsky, A. G., W. H. Crosby and H. Rapport: Hereditary nonsperocytie hemolytic disease. A study of a singular familial hemolytic syndrome. Blood 9, 749, 1954.
Nevanlinna, H. R.: Factors affecting maternal Rh-immunization. Ann. Med. Exper. Biol. Fenniae (Suppl. 2 ) 31, 1, 1953.
Nijhoff, G. C.: Zur Pathologie des Hydrops universalis foetus et placentae. Zbl. Gynäk. 35, 808, 1911.
Potter, E. L.: Universal edema of the fetus unassociated with erythroblastosis. Amer. J. Obstet. Gynec. 46, 130, 1943.
Potter, E. L.: Rh. Chicago, The Yearbook Publishers Inc. 1947.
Potter, E. L.: Intervillous thrombi in placenta and their possible relation to erythroblastosis fetalis. Amer. J. Obstet. Gynec. 56, 959, 1948.
Race, R. B. and R. Sanger: Blood Groups in Man. Second edition. Springfield, Charles C. Thomas, 1954.
Reich, H.: Die gruppenspezifische Differenzierung der Plazentarorgane. Immunitäts. forsch. u. Exper. Therapie. 77, 449, 1932.
Rudolph, A. J., A. A. Abrahamov and J. F. DE Venecia: Another case of fetomaternal transfusion. J. Philipp. Med. Ass. 38, 134, 1962.
Sauer, J., J. Simek and V. Kilich: Abo Isoimmunisation following termination of pregnancy. Zbl. Gynäk. 85, 295, 1963.
Schmidt, A. L. C.: De placenta bij erythroblastosis. Nederl. Tschr. Geneesk. 93, 3732, 1949.
Schridde, H.: Die angeborene allgemeine Wassersucht. Munch. Med. Wschr., 57, 397, 1910.
Schubert, W.: Fruchttod und Hydrops Universalis durch Toxoplasmosis. Virch. Arch. Path. Anat. 330, 518, 1957.
Scott, J. S.: Pregnancy toxaemia associated with hydrops foetalis, hydatidiform mole and hydramnios. J. Obstet. Gynaec. Brit. Emp. 65, 589, 1958.
Silverstein, A. M.: Congenital syphilis and the timing of immunogenesis in the human foetus. Nature (Lond.) 194, 196, 1962.
Silverstein, A. M.: Ontogeny of the immune response. Science 144, 1423, 1964.
Silverstein, A. M. and R. J. Lukes: Fetal response to antigenic stimulus. Lab. Invest. 11, 918, 1962.
Sitzenfrey, A.: Odem der Placenta und Kongenitale Akute Nephritis mit Hochgradigem Universellen Odem bei Zwillingen, die von einer an akuter Nephritis leidenden Mutter stammen. Zbl. Gynäk. 34, 1381, 1910.
Soergel, W.: Different degrees of haemolytic disease due to Rhesus incompatibility in a pair of twins following repeated stillbirths. Zbl. Gynäk. 85, 768, 1963
Strauss, L. and S. G. Driscoll: Congenital neuroblastoma involving the placenta. Reports of two cases. Pediatrics 341, 23, 1964.
Teuffel, R.: Zur Pathologie des Hydrops Foetus Universalis. Zbl. Gynäk. 35, 406, 1911.
Weisert, O. and J. Marstrander: Severe anemia in a newborn caused by protracted feto-maternal “transfusion”. Acta Paediat., Uppsala 49, 426, 1960.
Wigglesworth, J. S.: The Langhans layer in late pregnancy: a histological study of normal and abnormal cases. J. Obstet. Gynaec. Brit. Emp. 69, 355, 1962.
Wimhofer, H., J. Schneider and F. Leidenberger: Studies on the passage of fetal erythrocytes into the maternal circulation in spontaneous delivery and obstetrical surgery. Geburtsh. Frauenheilk. 22, 589, 1952.
Zacks, S. I. and A. S. Blazar: Chorionic villi in normal pregnancy, pre-eclamptic toxemia, erythroblastosis, and diabetes mellitus. Obstet. Gynec. 22, 149, 1963.
Zipursky, A. and B. Chown: Fetal erythrocytes in the circulation of the pregnant woman. Amer. J. Dis. Child. 100, 750, 1960.
Zipursky, A., A. Hull, F. D. White, L. G. Israels: Fetal erythrocytes in the maternal circulation. Lancet 1, 451, 1959.
Zipursky, A., J. Pollock, P. Neelands, B. Chown and L. G. Israels: Transplacental passage of fetal red blood cells and pathogenesis of Rh immunization during pregnancy. Lancet 22, 489, 1963.
Zipursky, A., J. PoLlock, B. Chown and L. G. Israels: Transplacental isoimmunization by fetal red blood cells. Birth Defects. Original Article Series 1, 84, 1965.
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Strauss, F., Benirschke, K., Driscoll, S.G. (1967). Hemolytic disease of the newborn. In: Strauss, F., Benirschke, K., Driscoll, S.G. (eds) Placenta. Handbuch der Speziellen Pathologischen Anatomie und Histologie, vol 7/5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25615-2_11
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