Importance of Stratificational Inhomogenity for Pulmonary Gas Exchange

  • J. Piiper
  • F. Adaro
Part of the Verhandlungen der Gesellschaft für Lungen- und Atmungsforschung book series (VGLA)


The limiting effects of stratification on the effectiveness of alveolar gas exchange have been calculated using the values for diffusive conductance of distal airways obtained from an analysis of washout kinetics of He and SF6 by Okubo and Piiper (1974). For the lungs of 10 kg dogs, the stratificational component of the alveolar-arterial Po2 difference is estimated at about 0. 8 torr for resting conditions and at about 3. 5 torr for medium level exercise.


  1. 1.
    Okubo, T., Piiper, J.: Intrapulmonary gas mixing in excised dog lung lobes studied by simultaneous wash-out of two inert gases. Respir. Physiol. 21, 223–239 (1974)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1976

Authors and Affiliations

  • J. Piiper
    • 1
  • F. Adaro
    • 2
  1. 1.Abteilung PhysiologieMax-Planck-Institut für Experimentelle MedizinGöttingenGermany
  2. 2.Abteilung PhysiologieMax-Planck-Institut für Experimentelle MedizinGöttingenGermany

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