Advertisement

Theophylline Blood Levels with Theophylline Ethylene Diamine

  • J. Ahrens
Part of the Verhandlungen der Gesellschaft für Lungen- und Atmungsforschung book series (VGLA)

Abstract

Theophylline blood levels following administration of theophylline ethylene diamine, intravenously, orally, and rectally, are compared and correlated with effectiveness of broncholytic action and toxicity. For long-term treatment of patients with airway obstructions the maintenance of constant theophylline plateau concentrations in plasma is desirable. This can be achieved by infusion of the drug at a constant rate after an initial loading dose, by treatment with suppositories due to the slow and limited rectal absorption of aminophylline, and by application of a new retard preparation where the sustained release of the drug determines the rate of gastrointestinal absorption of theophylline. In all three cases the dosage can be adjusted easily to the individually different pharmacokinetic properties of the patients.

Key words

Aminophylline Blood level Half-lifes Long-term treatment 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ahrens, J., Krieger, E.: Theophyllin-Blutspiegel und broncholytische Wirkung bei rektaler Applikation. Atemwegs- und Lungenkrankheiten 1, 173 (1975)Google Scholar
  2. 2.
    Mitenko, P. A., Ogilvie, R.I.: Rational intravenous doses of theophylline. New England J. Med. 289, 600 (1973)CrossRefGoogle Scholar
  3. 3.
    Mitenko, P. A., Ogilvie, R.I.: Pharmacokinetics of intravenous theophylline. Clin. Pharmacol. Ther. 14, 509 (1973)PubMedGoogle Scholar
  4. 4.
    Schack, J. A., Waxler, S. H.: An ultraviolet spectrophotometric method for determination of theophylline and theobromine in blood and tissues. J. Pharmacol. Ex. Ther. 97, 283 (1949)Google Scholar
  5. 5.
    Wiessman, K. J.: Der Einfluß eines oralen Aminophyllin-Präparates mit Retardwirkung auf die Lungenfunktionsparameter bei obstruktiven Atemwegserkrankungen. Dtsch. med. Wschr. 100, 1781 (1975)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1976

Authors and Affiliations

  • J. Ahrens
    • 1
    • 2
  1. 1.Abteilung Klinische ForschungBYK GULDEN KonstanzKonstanzGermany
  2. 2.Department of Clinical ResearchBYK GULDEN KonstanzGermany

Personalised recommendations