Abstract
Airway smooth muscle in vivo is exposed to stimuli from chemical mediators, neurotransmitters, prostaglandins and exogenous drugs. Contractile responses of airway smooth muscle, in asthma and in experimental guinea pig anaphylaxis, may depend to a large extent on the balance between these contractile and relaxant stimuli, and on their interactions.
Supported in part by a Specialized Center of Reserach grant (HE-14179) from the National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bouhuys, A., Jönsson, R., Lichtneckert, S., Lindell, S. E., Lundgren, C., Lundin, G., Ringquist, T.: Effect of histamine on pulmonary ventilation in man. Clin. Sci. 19, 79–94 (1960)
Brink, C., Ridgway, P., Douglas, J. S., Bouhuys, A.: Antinflammatory drugs and airway responses in the guinea pig. Fed. Proc. 34, 798 (1975) (Abs.)
Douglas, J. S., Dennis, M. W., Ridgway, P., Bouhuys, A.: Airway dilatation and constriction in spontaneously breathing guinea pigs. J. Pharmacol. Exp. Ther. 180, 98–109 (1972)
Douglas, J. S., Dennis, M. W., Ridgway, P., Bouhuys, A.: Airway constriction in guinea pigs: interaction of histamine and autonomic drugs. J. Pharmacol. Exp. Ther. 184, 169–179 (1973)
Orehek, J., Douglas, J. S., Lewis, A. J., Bouhuys, A.: Prostaglandin regulation of airway smooth muscle tone. Nature New Biol. 245, 8485 (1973)
Orehek, J., Douglas, J. S., Bouhuys, A.: Contractile responses of the guinea pig trachea in vitro: modification by prostaglandin-synthesis inhibiting drugs. J. Pharmacol. Exp. Ther. 194, 554–564 (1975)
Popa, V., Douglas, J. S., Bouhuys, A.: Airway responses to histamine, acetylcholine, and antigen in sensitized guinea pigs. J. Lab. Clin. Med. 84, 225–234 (1974)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Bouhuys, A. (1976). Experimental Studies on Airway Smooth Muscle Responses. In: Ulmer, W.T. (eds) Leistungsbegrenzung von seiten der Lunge. Verhandlungen der Gesellschaft für Lungen- und Atmungsforschung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25411-0_28
Download citation
DOI: https://doi.org/10.1007/978-3-662-25411-0_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-23364-1
Online ISBN: 978-3-662-25411-0
eBook Packages: Springer Book Archive