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Uses of Neuronal Transplantation in Models of Neurodegenerative Diseases

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Neural Transplantation and Regeneration

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

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Abstract

The experimental use of intracerebral neuronal grafting has expanded greatly in the last 10 years, as compared to any other time in history, though the basic methodology has been available for centuries. Early experiments focused on determining whether intracerebral grafting was possible (see, e.g., Saltykow 1905, Thompson 1890, Del Conte 1907, Dunn 1917). Subsequently, the parameters for optimal grafting were sought for a variety of approaches, focusing on issues such as age of donor (Olson et al. 1982, Kromer et al. 1983, Das et al. 1980), age of host (Hallas et al. 1980, Azmitia et al. 1981), cross-species compatibility (Björklund et al. 1982, Freed 1983, Low et al. 1983), host-graft interconnections (Björklund et al. 1976, 1979a, McLoon and Lund 1980a,b), target specificity (Lund et al. 1982), and vascularization (Stenevi et al. 1976). These critical experiments continue, revealing more information about the limits and potentials for graft survival and integration with the host brain.

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  1. Fred H. Gage

    Present address: Department of Neurosciences, University of California, San Diego, La Jolla, California, 92093, USA

Authors and Affiliations

  1. Department of Histology, University of Lund, S-223 62, Lund, Sweden

    Fred H. Gage, Anders Björklund, Ole Isacson & Patrik Brundin

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  1. Department of Biological Sciences, Purdue University, 47907, West Lafayette, Indiana, USA

    Gopal D. Das

  2. Departments of Psychology and Biology, University of Hartford, 06117, West Hartford, Connecticut, USA

    Robert B. Wallace

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Gage, F.H., Björklund, A., Isacson, O., Brundin, P. (1986). Uses of Neuronal Transplantation in Models of Neurodegenerative Diseases. In: Das, G.D., Wallace, R.B. (eds) Neural Transplantation and Regeneration. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25264-2_4

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