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Neural Transplantation and Regeneration pp 287–326Cite as

A Behavioral and Histological Examination of Young Rats Receiving Homotopic Embryonic Neural Transplants in Motor Cortex

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Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Neural transplantation is a field extensively researched from as early as the beginning of the twentieth century. Studies have been conducted with three broadly defined objectives and have evolved chronologically as follows: (1) the use of transplants (both neuronal and extraneuronal) simply to assess the viability of “nerve grafts,” and as a tool for studying regeneration in the central nervous system; (2) studies centering on neural transplantation as a method for elucidating the phenomena of neuronal migration and specificity and the relationship of these events to the ordering of the CNS during embryogenesis; and (3) neural transplantation from the standpoint of a technically viable and specialized field of research, with emphasis on the anatomical, functional, and physiological nature of the transplants. It has been in the context of this latter domain that the clinical implications of transplantation work have recently received considerable attention. A review of the primary studies carried out in these three general subgroups follows.

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References

  • Bures, J., Burresova, D., Huston, J. (1976). Techniques and Basic Experiments for the Study of Brain and Behavior. Amsterdam: Elsevier Scientific Publishing Co.

    Google Scholar 

  • Björklund, A., Segal, M., Stenevi, U. (1979). Functional reinnervation of rat hippocampus by locus coeruleus implants. Brain Res. 170, (pt 3) 409–426.

    Article  PubMed  Google Scholar 

  • Björklund, A., Stenevi, U. (1979). Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. 177, 555–560.

    Article  PubMed  Google Scholar 

  • Castro, A. (1972). The effects of cortical ablations on digital usage in the rat. Brain Res. 37, 173–185.

    Article  PubMed  CAS  Google Scholar 

  • D’Amato, C., Hicks, S. (1980). Development of the motor system: Effects of radiation on developing corticospinal neurons and locomotor function. Exp. Neurol. 70, 1–23.

    Article  PubMed  Google Scholar 

  • Das, G.D. (1973). Transplantation of cerebellar tissue in the cerebellum of neonate rabbits. Brain Res. 50, 170–173.

    Article  PubMed  CAS  Google Scholar 

  • Das, G.D. (1974). Transplantation of embryonic neural tissue in the mammalian brain. I. Growth and differentiation of neuroblasts from various regions of the embryonic brain in the cerebellum of neonate rats. TIT J. Life Sci. 4, 93–124.

    CAS  Google Scholar 

  • Das, G.D. (1975). Differentiation of dendrites in the transplanted neuroblasts in the mammalian brain. In: Advances in Neurology, Vol. 12. Kreutzberg, G.W. (ed.). New York: Raven Press.

    Google Scholar 

  • Das, G.D. (1976). Transplantation of neuroblasts in the brain of rat: Dendritic differentiation. Anat. Rec. 184, 388.

    Google Scholar 

  • Das, G.D. (1977). Transplantation of embryonic neural tissue in the brain of the adult rats. Anat. Rec. 187, 563.

    Google Scholar 

  • Das, G.D. (1978). Neural transplants in the brain of the rat: Nature of degenerative changes in the host brain and the transplant. Anat. Rec. 193, 517.

    Google Scholar 

  • Das, G.D. (1981). Neural transplants in the spinal cord of the adult rat. Anat. Rec. 199, 64A.

    Google Scholar 

  • Das, G.D. (1982). Extraparenchymal neural transplants: Their cytology and survivability. Brain Res. 241, 182–186.

    Article  PubMed  CAS  Google Scholar 

  • Das, G.D., Altman, J. (1971). Transplanted precursors of nerve cells: Their fate in the cerebellums of young rats. Science 173, 637–638.

    Article  PubMed  CAS  Google Scholar 

  • Das, G.D., Altman, J. (1972). Studies on the transplantation of developing neural tissue in the mammalian brain. I. Transplantation of cerebellar slabs into cerebellum of neonate rats. Brain Res. 38, 233–249.

    Article  PubMed  CAS  Google Scholar 

  • Das, G.D., Hallas, B. (1978). Transplantation of brain tissue in the brain of adult rats. Experientia, 34, 1304–1306.

    Article  PubMed  CAS  Google Scholar 

  • Das, G.D., Hallas, B., Das, K. (1979). Transplantation of neural tissue in the brains of laboratory mammals: Technical details and comments. Experientia, 35, 143–153.

    Article  PubMed  CAS  Google Scholar 

  • Das, G.D., Hallas, B., Das, K. (1980). Transplantation of brain tissue in the brain of rat. I. Growth characteristics of neocortical transplants from embryos of different ages. Am. J. Anat. 158, 135–146.

    CAS  Google Scholar 

  • Dunn, E. (1917). Primary and secondary findings in a series of attempts to transplant cerebral cortex in the albino rat. J. Comp. Neurol. 27, 565–582.

    Article  Google Scholar 

  • Gash, D., Roos, T., Chambers, W. (1975). Development of Rathke’s pouch tissue transplanted into adult hypophysectomized female rats. Neuroendocrinology 19, 214–226.

    Article  PubMed  CAS  Google Scholar 

  • Gash, D., Sladek, J., Sladek, C. (1979). Development of normal fetal supraoptic neurons grafted into adult rats with a congenital lack of vasopressin producing neurons. Soc. Neurosci. Abst. 5, 445.

    Google Scholar 

  • Gentile, A.M., Green, S., Nieburgs, A., Schmelzer, W., Stein, D.G. (1978). Disruption and recovery of locomotor and manipulatory behavior following cortical lesions in rats. Behay. Bio. 22, 417–455.

    Article  CAS  Google Scholar 

  • Glees, P. (1955). Studies on cortical regeneration with special reference to cerebral implants. In: Regeneration in the Central Nervous System. Windle, W.F. (ed.). Springfield, IL: C.C. Thomas.

    Google Scholar 

  • Hall, R., Lindholm, E. (1974). Organization of motor and somatosensory neocortex in the albino rat. Brain Res. 66, 23–38.

    Article  Google Scholar 

  • Hallas, B., Das, G.D., Das, K. (1980a). Transplantation of brain tissue in the brain of rat. II. Growth characteristics of neocortical transplants in hosts of different ages. Am. J. Anat. 158, 147–159.

    Article  PubMed  CAS  Google Scholar 

  • Hallas, B., Oblinger, M., Das, G. (1980b). Heterotopic neural transplants in the cerebellum of the rat: Their afferents. Brain Res. 196, 242–246.

    Article  PubMed  CAS  Google Scholar 

  • Harvey, A., Lund, R. (1981). Transplantation of tectal tissue in rats. II. Distribution of host neurons which project to transplants. J. Comp. Neurol. 201, 505–520.

    Article  Google Scholar 

  • Houle, J., Das, G.D. (1980a). Freezing and transplantation of brain tissue in rats. Experientia 30, 1114–1115.

    Article  Google Scholar 

  • Houle, J., Das, G.D. (1980b). Freezing of embryonic neural tissue and its transplantation in the rat brain. Brain Res. 192, 570–574.

    Article  PubMed  CAS  Google Scholar 

  • Jaeger, C., Lund, R. (1978). Development of cerebral cortex transplanted to cerebral

    Google Scholar 

  • cortex or tectum of newborn rat hosts. Soc. Neurosci. Abst. 4, 116.

    Google Scholar 

  • Jaeger, C., Lund, R. (1979a). Connections between cerebral cortex transplants and rat

    Google Scholar 

  • host brain. Soc. Neurosci. Abst. 5, 628.

    Google Scholar 

  • Jaeger, C., Lund, R. (1979b). Efferent fibers from transplanted cerebral cortex of rats. Brain Res. 165, 338–342.

    Article  PubMed  CAS  Google Scholar 

  • Jaeger, C., Lund, R. (1980a). Transplantation of embryonic occipital cortex to the brain of newborn rats. An autoradiographic study of transplant histogenesis. Exp. Brain Res. 40, 265–272.

    Article  PubMed  CAS  Google Scholar 

  • Jaeger, C., Lund, R. (1980b). Transplantation of occipital cortex to the tectal region of newborn rats: A light microscopic study of organization and connectivity of the transplants. J. Comp. Neurol. 194, 571–598.

    Article  PubMed  CAS  Google Scholar 

  • Jaeger, C., Lund, R. (1981). Transplantation of embryonic occipital cortex to the brain of newborn rats: A Golgi study of mature and developing transplants. J. Comp. Neurol. 200, 213–230.

    Article  PubMed  CAS  Google Scholar 

  • Kimura, H., McGeer, P., Noda, Y., McGeer, E. (1980). Brain transplants in an animal “model” of Huntington’s disease. Soc. Neurosci. Abst. 6, 688.

    Google Scholar 

  • Kluver, H., Barrera, E. (1953). A method for the combined staining of cells and fibers in the nervous system. J. Neuropath. Exp. Neurol. 12, 400–403.

    Article  PubMed  CAS  Google Scholar 

  • Krieg, W. (1946a). Connections of the cerebral cortex. I. The albino rat. A. Topography of the cortical areas. J. Comp. Neurol. 84, 221–275.

    CAS  Google Scholar 

  • Krieg, W. (1946b). Connections of the cerebral cortex. I. The albino rat. B. Structure of the cortical areas. J. Comp. Neurol. 84, 277–324.

    CAS  Google Scholar 

  • Kromer, L. (1980). Glial scar formation in the brain of adult rats is inhibited by implants of embryonic CNS tissue. Soc. Neurosci. Abst. 6, 688.

    Google Scholar 

  • Lacey, D. (1944). A revised procedure for the calibration of the activity wheel. Am. J. Psych. 57, 411.

    Google Scholar 

  • Lashley, K. (1921). Studies of cerebral function in learning. No. III. The motor area. Brain 44, 255–285.

    Article  Google Scholar 

  • Le Gros Clark, W.E. (1940). Neuronal differentiation in implanted foetal cortical tissue. J. Neurol. Psych. (London) 3, 263–272.

    Article  CAS  Google Scholar 

  • Le Gros Clark, W.E. (1942). The problem of neuronal regeneration in the central nervous system. I. The influence of spinal ganglia and nerve fragments grafted in the brain. J. Anat. 77, 20–48.

    Google Scholar 

  • Le Gros Clark, W.E. (1943). The problem of neuronal regeneration in the central nervous system. II. The insertion of peripheral nerve stumps into the brain. J. Anat. 77, 251–258.

    Google Scholar 

  • Lund, R., Harvey, A. (1981). Transplantation of tectal tissue in rats. I. Organization of transplants and pattern distribution of host afferents within them. J. Comp. Neurol. 201, 191–209.

    CAS  Google Scholar 

  • Lund, R., Hauschka, S. (1976). Transplanted neural tissue develops connections with host rat brain. Science 193, 582–584.

    Article  PubMed  CAS  Google Scholar 

  • Lundberg, J., Mollgard, K. (1979). Mitotic activity in adult rat brain induced by implantation of pieces of fetal rat brain and liver. Neurosci. Lett. 13, 265–270.

    Article  PubMed  CAS  Google Scholar 

  • Maier, N. (1935). The cortical area concerned with coordinated walking in the rat. J. Comp. Neurol. 61, 395–405.

    Article  Google Scholar 

  • McLoon, S., Lund, R. (1979). Development of retina transplanted to the tectum of neonatal rats. Soc. Neurosci. Abst. 5, 631.

    Google Scholar 

  • McLoon, S., Lund, R. (1980). Specific projections of retina transplanted to rat brain. Exp. Brain Res. 40, 273–282.

    Article  PubMed  CAS  Google Scholar 

  • McLoon, L., McLoon, S., Lund, R. (1981). Cultured embryonic retinae transplanted to rat brain: Differentiation and formation of projections to host superior colliculus. Brain Res. 226, 15–31.

    Article  PubMed  CAS  Google Scholar 

  • Oblinger, M., Das, G.D. (1981). Age of host as an influencing factor on the growth and connectivity of neural transplants in the cerebellar hemisphere of the rat. Anat. Rec. 199, 185A - 186A.

    Google Scholar 

  • Oblinger, M., Hallas, B., Das, G.D. (1980). Neocortical transplants in the cerebellum of the rat: Their afferents and efferents. Brain Res. 189, 228–232.

    Article  PubMed  CAS  Google Scholar 

  • Perlow, M., Freed, W., Karoum, D., Hoffer, B., Seiger, A., Olson, L., Wyatt, R. (1979). Substantia nigra grafts reduce motor abnormalities produced by destruction of negro-striatal dopamine system. Soc. Neurosci. Abst. 5, 681.

    Google Scholar 

  • Price, A., Fowler, S. (1981). Deficits in contralateral and ipsilateral forepaw motor control following unilateral motor cortical ablations in rats. Brain Res. 205, 81–90.

    Article  PubMed  CAS  Google Scholar 

  • Ramon y Cajal, S. (1928). Degeneration and Regeneration of the Nervous System, Vols. 1 and 2. May, R.M. (trans. and ed.). London: Oxford University Press.

    Google Scholar 

  • Ranson, S. (1903). On the medullated nerve fibers crossing the site of lesions in the brain of the white rat. Comp. Neurol. 13, 185–207.

    Article  Google Scholar 

  • Ranson, S. (1914). Transplantation of the spinal ganglion, with observations on the significance of complex types of spinal ganglion cells. J. Comp. Neurol. 24, 547–558.

    Article  Google Scholar 

  • Saltykow, S. (1905). Versuche uber Gehirnplantation, zugleich ein Beitrag zur Kenntniss der Vorgange an den Zelligen Gehirnelementen. Arch. Psych. (Berlin) 40, 329–388.

    Article  Google Scholar 

  • Settlage, P., Bingham, W., Suckle, H., Borge, A., Woolsey, C. (1949). The pattern of localization in the motor cortex of rat. Fed. Proc. 8, 114.

    Google Scholar 

  • Spiliotis, P., Thompson, R. (1973). The “manipulative response memory system” in the white rat. Physiol. Psych. 1, 101–114.

    Google Scholar 

  • Stenevi, U., Björklund, A., Svendgaard, N. (1976). Transplantation of central and peripheral monamine neurons to the adult rat brain: Techniques and conditions for survival. Brain Res. 114, 1–20.

    Article  PubMed  CAS  Google Scholar 

  • Svendgaard, N. (1977). Transplantation of monoaminergic neurons to the adult rat brain: Conditions for survival and mode of growth. Acta Neurochir. 37, 302.

    Google Scholar 

  • Tidd, C.W. (1932). The transplantation of spinal ganglion of the white rat. A study of the morphological changes in surviving cells. J. Comp. Neurol. 55, 531–543.

    Article  Google Scholar 

  • Tupper, D., Wallace, R. (1980). Utility of the neurological examination in rats. Acta

    Google Scholar 

  • Neurobiol. Exp. 40, 999–1003.

    Google Scholar 

  • Wallace, R., Das, G.D. (1982). Behavioral effects of CNS transplants in the rat. Brain Res. 243, 133–139.

    Article  PubMed  CAS  Google Scholar 

  • Weinberg, E., Raine, C. (1980). Reinnervation of peripheral nerve segments implanted into the rat central nervous system. Brain Res. 198, 1–11.

    Article  PubMed  CAS  Google Scholar 

  • Wenzel, J., Barlehner, F. (1969). Zur regeneration des Cortex cerebri bei Mus masculus. II. Morphologische Befunde regenerativer Vorgange nach Replantation eines Cortexabschnittes. Z. Mikroskop. Forsch. 81, 32–70.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Psychology and Biology, University of Hartford, West Hartford, Connecticut, 06117, USA

    Robert B. Wallace

Authors
  1. Jeffrey Harnsberger
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  2. Robert B. Wallace
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Editors and Affiliations

  1. Department of Biological Sciences, Purdue University, 47907, West Lafayette, Indiana, USA

    Gopal D. Das

  2. Departments of Psychology and Biology, University of Hartford, 06117, West Hartford, Connecticut, USA

    Robert B. Wallace

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Harnsberger, J., Wallace, R.B. (1986). A Behavioral and Histological Examination of Young Rats Receiving Homotopic Embryonic Neural Transplants in Motor Cortex. In: Das, G.D., Wallace, R.B. (eds) Neural Transplantation and Regeneration. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25264-2_12

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  • DOI: https://doi.org/10.1007/978-3-662-25264-2_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-96160-4

  • Online ISBN: 978-3-662-25264-2

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