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Neural Transplantation in Spinal Cord under Different Conditions of Lesions and Their Functional Significance

  • Chapter
Neural Transplantation and Regeneration

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

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Abstract

Research on the problems of trauma and regeneration in the spinal cord has a long history. The importance of this research lies in the fact that trauma to this structure deprives the individual of voluntary control over the basic motor functions, such as movement of limbs involved in locomotion. The severity of trauma and the level of spinal cord where it is inflicted determine the nature and magnitude of loss of motor functions. Understanding the complexity of pathological events ensuing from the trauma, the nature and permanency of the functional loss, and the difficulties inherent in the restitution of the lost functions has been a concern for investigators in many fields. Pathologists, neuro-biologists, neuroembryologists, and neurosurgeons, among others, have contributed to a considerable extent within their respective domains towards explaining why, following a serious trauma, there is no functional recovery, and have speculated variously on how to achieve it. At different periods, various investigators claimed recovery of lost locomotor functions following surgical or pharmacological treatments. But those claims could not be supported by other investigators working independently. Thus, despite the great progress made towards an understanding of the pathological events and the problems of limited or no regeneration of damaged fiber systems, the goal of achieving recovery of the lost motor functions has remained beyond our reach.

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  1. Department of Biological Sciences, Purdue University, West Lafayette, Indiana, 47907, USA

    Gopal D. Das

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  1. Department of Biological Sciences, Purdue University, 47907, West Lafayette, Indiana, USA

    Gopal D. Das

  2. Departments of Psychology and Biology, University of Hartford, 06117, West Hartford, Connecticut, USA

    Robert B. Wallace

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Das, G.D. (1986). Neural Transplantation in Spinal Cord under Different Conditions of Lesions and Their Functional Significance. In: Das, G.D., Wallace, R.B. (eds) Neural Transplantation and Regeneration. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25264-2_1

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