Transport of Biological Amines as an Element of Drug Action
The amine concentration in the various amine-storing cells in the body may reach fairly high values. In the adrenal medulla, for example, the catecholamine concentration may be higher than 1% of the fresh weight. Within these cells the major fraction of the amines occur in specific storage particles, “granules” or “synaptic vesicles’, in which the concentration is several times higher. However, the last two years’ research has shown that storage in particles is not the only amine-concentrating mechanism. In adrenergic neurons, and possibly other amine-storing neurons, there is another mechanism probably located at the level of the cell membrane.
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