Effect of 5-Hydroxytryptamine on Sodium Transport across Bullfrog Skin
5-hydroxytryptamine (5 HT) has been shown to promote the reabsorption of sodium by the renal tubule (Blackmore 1958, Little et al. 1961); it is also considered as an inhibitory transmitter substance in the central nervous system (Brodie and Shaw 1957, Twarog 1954). Despite these and other important rôles played by 5 HT, its effect on membrane permeability and transport in relatively well-defined systems is not known. Hence, this investigation was undertaken to study the effect of 5 HT on sodium transport across frog skin.
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