Nitric Oxide: A Messenger of Cerebellar Granule Cells

  • Jarda T. Wroblewski
  • Lech Kiedrowski
  • Robert Raulli
  • Erminio Costa
Conference paper
Part of the Schering Foundation Workshop book series (SCHERING FOUND, volume 3)


In the central nervous system glutamate activates ionotropic and metabotropic subtypes of excitatory amino acid receptors, leading to increased ion fluxes and to the stimulation of several intracellular messenger systems [1]. Among them is the stimulation of guanylate cyclase and the ensuing accumulation of cyclic GMP (cGMP). The most prominent cGMP increases in response to excitatory amino acids have been found in the cerebellum [2, 3]. In this brain area several neuronal pathways such as parallel, climbing and mossy fibers use either glutamate or aspartate as neurotransmitter [4]. The stimulation of N-methyl-d-aspartate (NMDA)-sensitive glutamate receptors was shown to increase cGMP concentration in the rat cerebellum in vivo [5] as well as in slices [6, 7], dissociated cells [8] and primary cultures [9, 10] prepared from rat cerebellum.


Nitric Oxide NMDA Receptor Granule Cell Guanylate Cyclase Cerebellar Granule Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Jarda T. Wroblewski
  • Lech Kiedrowski
  • Robert Raulli
  • Erminio Costa

There are no affiliations available

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