Nitric Oxide: A Messenger of Cerebellar Granule Cells
In the central nervous system glutamate activates ionotropic and metabotropic subtypes of excitatory amino acid receptors, leading to increased ion fluxes and to the stimulation of several intracellular messenger systems . Among them is the stimulation of guanylate cyclase and the ensuing accumulation of cyclic GMP (cGMP). The most prominent cGMP increases in response to excitatory amino acids have been found in the cerebellum [2, 3]. In this brain area several neuronal pathways such as parallel, climbing and mossy fibers use either glutamate or aspartate as neurotransmitter . The stimulation of N-methyl-d-aspartate (NMDA)-sensitive glutamate receptors was shown to increase cGMP concentration in the rat cerebellum in vivo  as well as in slices [6, 7], dissociated cells  and primary cultures [9, 10] prepared from rat cerebellum.
KeywordsToxicity Arginine Hydrolase Pertussis Nitroglycerin
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