Abstract
Liver is the largest organ and carries out the most complex biologic functions in the body. It secretes bile, synthesizes proteins, metabolizes nutrients, hormones, and drugs and detoxifies noxious endogenous and exogenous substrates. To accomplish all of these functions, the liver is located centrally in the body with well designed architecture and is supplied with a generous amount of blood. Secretion of bile is one of many important liver functions. Bile promotes digestion and absorption of essential nutrients and also serves as a vehicle to get rid off biologic waste products from the body. The biliary tree is designed not only for continuous bile secretion but also for periodic bile storage and discharge at the time when food enters the small intestine. Spleen carries out many functions whose importance has been recognized only recently. This chapter will discuss various functions of these two organs.
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References
Fitz JG. Cellular mechanism of bile secretion. In: Zakim D, Boyer TD, eds. Hepatology. A textbook of liver disease. Philadelphia, WB Saunders Co. 1996: pp 362–376
Boyer JL, Klatskin G. Canalicular bile flow and bile secretory pressure. Evidence for a non-bile salt dependent fraction in the isolated perfused rat liver. Gastroenterology 1970; 59: 853–859
Brauer RW, Leong SF, Holloway RJ. Mechanism of secretion. Effect of perfusion pressure and temperature on bile flow and bile secretion pressure. Am J Physiology 1954; 177: 103–106
Jones AL, Schmucker DL, Renston RH, Murakami T. The architecture of bile secretion. A morphological perspective of physiology. Dig Dis Sci 1980; 25: 609–629
Sherlock S, Dooley J. Cholestasis. Diseases of the liver and biliary system, 10th edition, Blackwell Science, Malden, MA. 1997, pp 217–237
Sellinger M, Barrett C, Malle P, Gordon ER, Boyer JL. Cryptic Na+, K+-ATPase activity in the rat liver canalicular plasma membranes: evidence for its basolateral origin. Hepatology 1990; 11: 223–229
Meier PJ. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am J Physio1269: G801 - G812, 1995
Trauner M, Meier PJ, Boyer JL. Molecular pathogenesis of cholestasis. N Engl J Med 1998: 339: 1217 1227
Kamimato Y, Gatmaitan Z, Hsu J, Arias IM. The function of Gp 170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J Biol Chem 1989; 264: 11693–11698
Goresky CA. Initial distribution and rate of sulfobromophthalein in the liver. Am J Physiology 1964; 207: 13–16
Donohue TM Jr., Tuma DJ, Sorrell ME Plasma proteins metabolism. In: Zakim D, Boyer TD. Hepatology. A text book of liver disease, 3rd edition. Philadelphia, WB Saunders Co., 1996; 130–148
Krishnamurthy GT, Bobba VR, McConnel D, Turner F, Mesgarzadeh M, Kingston E. Quantitative biliary dynamics: Introduction of a new noninvasive scintigraphic technique. J Nucl Med 1983; 24; 217–223
Vlahcevic ZR, Heuman DM, Hylemon PB. Physiology and pathology of enterohepatic circulation of bile acids. In: Zakin D, Boyer TD (eds.). Hepatology. A textbook of liver disease. 1996. Philadelphia, W.B. Saunders Co. pp 376–417
Wheeler HO. Concentrating function of the gallbladder Am J Med 1971; 51: 588–595
Krishnamurthy S, Krishnamurthy GT. Evolution of nuclear hepatology as a clinical subspeciality. J Nucl Med Technol 1995;23:35S–45S (supplement)
Thune A, Scicchitano J, Roberts-Thompson I, Toouli J. Reproducibility of endoscopic sphincter of Oddi manometry. Dig Dis Sci 1991; 36: 1401–1405
Lee SK, Kim MH, Seo DW, Yoo BM, Lee MH, Myung SJ, Min YI. Frequency of phasic wave contraction is variable during long-term sphincter of Oddi manometry. Am J Gastroenterol 1996; 91: 2395–2398
Fisher RS, Rock E, Malmud LS. Gallbladder emptying response to sham feeding in humans. Gastroenterology 1986; 90: 1854–1857
Ivy AC, Oldberg E. A hormone mechanism of gallbladder contraction and evacuation. Am J Physiology 1928; 86: 599–613
Mutt V. Cholecystokinin: isolation, structure, and function. In: Jerzy Glass GB. ed. Gastrointestinal hormones. New York, Raven Press, 1980, pp 169–221
Bobba VR, Krishnamurthy GT, Kingston E, Turner FE, Brown PH, Langrell K. Gallbladder dynamics induced by a fatty meal in normal subjects and patients with gallstones: Concise communication. J Nucl Med 1984; 25: 21–24
Bloom SR, Adrian TE, Mitchenere P, et al. Motilin induced gallbladder contraction. A new mechanism. Gastroenterology 1981; 80: 1113
Mattsson O. Scintigraphic spleen volume calculation. Acta Radiol [Diagn] (Stockh) 1982; 23: 47 1477
Spencer RP, Pearson HA. The spleen as a hematological organ. Semin Nucl Med 1975; 5: 95–102
Gray SJ, Sterling K. The tagging of red blood cells and plasma proteins with radioactive chromium. J Clin Invest 1950; 29: 818
Pollycove M, Tono M. Blood volume. In: Sandler MP, Patton JH, Coleman RE, Gottschalk A, Wackers FJTh, Hopper PB. Diagnostic Nuclear Medicine, 3rd edition, Williams and Wilkins, Baltimore, 1996, pp 827–834
Crosby WH, Normal functions of the spleen relative to red blood cells. A review. Blood 1959; 14: 399408
Pearson HA, Johnston D, Smith KA, Touloukian RJ. The born-again spleen. Return of splenic function after splenectomy for trauma. New Eng J Med 1978; 298: 1389–1392
Spencer RP. Spleen imaging. In: Sandler MP, Patton JH, Coleman RE, Gottschalk A, Wackers FJTh, Hopper PB. Diagnostic Nuclear Medicine, 3rd edition, Williams and Wilkins, Baltimore, 1996, pp 865–874
Hoeper MM, Niedermeyer J, Hoffmeyer F, Flemming P, Fabel H. Pulmonary hypertension after splenectomy? Ann Intern Med 1999; 130: 506–509
Leemans R, Manson W, Snijder JAM, Smit JW, Klasen HJ, The TH, Timens W. Immune response capacity after human splenic autotransplantation. Restoration of response to individual pneumococcal vaccine subtypes. Ann Surg 1999; 229: 279–285
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Krishnamurthy, G.T., Krishnamurthy, S. (2000). Liver and Spleen Function. In: Nuclear Hepatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22654-4_2
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DOI: https://doi.org/10.1007/978-3-662-22654-4_2
Publisher Name: Springer, Berlin, Heidelberg
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