Secretion of Mammalian Proteins that Lack a Signal Sequence

  • Anna Rubartelli
  • Roberto Sitia
Part of the Molecular Biology Intelligence Unit book series (MBIU)


Cells are surrounded by an impermeable membrane whose integrity is essential to maintain the differences (in ionic concentration, redox potential etc.) between the cytoplasm and the extracellular space. Yet, cells avoid isolation and communicate by sending each other macromolecular messages in the form of secretory proteins. These molecules, interacting with specific receptors that span the cell membrane, activate tightly regulated systems which transduce the signal to the nucleus and elicit the appropriate responses.


Signal Sequence Fibroblast Growth Factor Receptor Mammalian Protein Endoplasmic Reticulum Lumen Secretory Signal Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Anna Rubartelli
  • Roberto Sitia

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