Secretion of Mammalian Proteins that Lack a Signal Sequence

  • Anna Rubartelli
  • Roberto Sitia
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Cells are surrounded by an impermeable membrane whose integrity is essential to maintain the differences (in ionic concentration, redox potential etc.) between the cytoplasm and the extracellular space. Yet, cells avoid isolation and communicate by sending each other macromolecular messages in the form of secretory proteins. These molecules, interacting with specific receptors that span the cell membrane, activate tightly regulated systems which transduce the signal to the nucleus and elicit the appropriate responses.

Keywords

Cholesterol Lymphoma Leukemia Glutathione Cysteine 

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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Anna Rubartelli
  • Roberto Sitia

There are no affiliations available

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