As medical science has prolonged human life, it has also brought a sharp increase in the numbers of people suffering one of the most calamitous afflictions of old age. In this book, we have presented the rationale for the hypothesis that oxidative stress could be the common mediator of the entire pathologic cascade leading to neuronal death in major age-related neurodegenerative disorders. It is attractive to speculate that effective treatment, but above all prevention, of these diseases may be carried out by drugs operating at this important level of the pathogenic cascade. Lowering the ROS formation and thereby the associated ROS-damage by a large panel of antioxidants could be a challenge for the prevention of neurodegeneration.
KeywordsGlutathione Aspirin Adduct Neurol NMDA
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