As medical science has prolonged human life, it has also brought a sharp increase in the numbers of people suffering one of the most calamitous afflictions of old age. In this book, we have presented the rationale for the hypothesis that oxidative stress could be the common mediator of the entire pathologic cascade leading to neuronal death in major age-related neurodegenerative disorders. It is attractive to speculate that effective treatment, but above all prevention, of these diseases may be carried out by drugs operating at this important level of the pathogenic cascade. Lowering the ROS formation and thereby the associated ROS-damage by a large panel of antioxidants could be a challenge for the prevention of neurodegeneration.
KeywordsThiol Disulfide Thioctic Acid Central Nervous System Trauma Pathogenic Cascade Lipid Antioxidant
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- 1.The Parkinson’s study group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson’s disease. New Engl J Med 1993; 328: 176–183.Google Scholar
- 3.Hall ED, Braughler JM. Central nervous system trauma and stroke. II. Physiological and pharmacologic evidence for involvement of oxygen radicals and lipid peroxidation. Free Rad Biol Med 1989; 6: 303–313.Google Scholar
- 7.Mc Geer PL, Mc Geer E, Rogers J, Sibley J. Antiinflammatory drugs and Alzheimer’s disease. Lancet 1990; 335: 1037.Google Scholar
- 8.Marx J. Searching for drugs that combat Alzheimer’s. Science 1996; 273: 50–53.Google Scholar
- 11.Mattson MP, Lovell MA, Furukawa K, Markesbery WR. Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca“ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J Neurochem 1995; 65: 1740–1751.PubMedCrossRefGoogle Scholar
- 14.Veggeberg S. High performance antioxidants for a multitude of diseases. Mol Med Today 1996; 406–409.Google Scholar