Mechanisms of Action of Bisphosphonates as Inhibitors of Bone Resorption

  • Michael J. Rogers
  • R. Graham G. Russell
Part of the Medical Intelligence Unit book series (MIU.LANDES)


More than 25 years have passed since it was first recognized that bisphosphonates could inhibit bone resorption.1–3 During this time, bisphosphonates have become the treatment of choice for a variety of bone diseases in which excessive osteoclast activity is an important pathological feature, including Paget’s disease of bone,4 metastatic and osteolytic bone disease, hypercalcemia of malignancy5 and, more recently, postmenopausal and other forms of osteoporosis (Fig. 7.1).6,7 However, despite the widespread clinical use of bisphosphonates, their exact mechanism of action, at both the cellular and molecular level, have not been clearly identified.


Bone Resorption Inhibit Bone Resorption Mature Osteoclast Phosphonate Group Dichloromethylene Diphosphonate 
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© Springer-Verlag Berlin Heidelberg 1996

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  • Michael J. Rogers
  • R. Graham G. Russell

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