Abstract
Paget’s disease1 is characterized by excessive, uncoordinated, bone turnover resulting in disorganization of bone architecture, manifested most commonly as thickening, increased bone mass and deformity. Although commonly discussed in texts with the metabolic or generalized bone diseases the disease typically affects part or all of one, several or many bones, but never all the bones and usually only one or two. This simple, and frequently ignored fact, is the single most perplexing and frustrating aspect of the disease when consideration is given to the mechanisms underlying its pathogenesis.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Paget J. On a form of chronic inflammation of bones (osteitis deformans). Trans Med Chir Soc Lond 1877; 60: 37–63.
Dalinka MK, Aronchick JM, Haddad JG. Paget’s disease. Orthop Clin North Am 1983; 4: 3–19.
Cawley MID. Complications of Paget’s disease of bone. Gerontology 1983; 29: 276–287.
Mirra JM, Brien EW, Tehranzadeh J. Paget’s disease of bone: review with emphasis on radiologic features, part 1. Skeletal Radiology 1995; 3: 163–171.
Freemont AJ. Histology of mineralised tissues. In: Topics in molecular and structural biology, 11. In: Hukins DL, ed. Calcified Tissue. London: The MacMillan Press, 1989: 21–40.
Freemont AJ. Basic bone biology. Int J Exp Pathol 1993; 74: 411–416.
Collins DH. Pathology of Bone. London: Butterworths, 1966.
Milgram JW. Radiological and pathological assessment of the activity of Paget’s disease of bone. Clin Orthop 1977; 127: 43–54.
Schuller A. Dysostosis hypophysaria. Br J Radiol 1962; 31: 156–167.
Anderson DC, Richardson PC, Freemont AJ, Cantrill JC. Paget’s disease and its treatment with intravenous APD. Advances in Endocrinology 1989; 6: 156–164.
Harvey L, Gray T, Beneton MNC, Canis J. Ultrastructural features of the osteoclasts from Paget’s disease of bone in relation to a viral aetiology. J Clin Pathol 1982; 35: 771–9.
Singer FR and Mills BG. Evidence for a viral etiology of Paget’s disease of bone. Clin Orthop 1983; 178: 245–251.
Cartwright EJ, Gordon MT, Freemont AJ, Anderson DC, Sharpe PT. Paramyxovirus and Paget’s disease. J Med Virol 1993; 40: 133–141.
Hoyland JA, Freemont AJ, Sharpe PT. Interleukin-6 (IL-6), IL-6 receptor and IL-6 nuclear factor gene expression in Paget’s disease. J Bone Min Res 1994; 9: 75–80.
Krane SM, Kantrowitz FG, Byrne M, Pinnell SR, Singer FR. Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation. J Clin Invest 1977; 59: 819–827.
DeDeuxchaisnes CN, Krane S. Paget’s disease of bone: clinical and metabolic observations. Medicine 1964; 43: 233–266.
Altman RD, Collins B. Musculoskeletal manifestations of Paget’s disease of bone. Arth Rheum 1980; 23: 1121–1127.
Huvos AG. Bone tumours. Chapter 8. Tumours associated with Paget’s disease of bone. Vol II. Philadelphia: WB Saunders, 1991: 201–222.
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Freemont, A.J. (1996). The Pathology of Paget’s Disease. In: The Molecular Biology of Paget’s Disease. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22505-9_1
Download citation
DOI: https://doi.org/10.1007/978-3-662-22505-9_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-22507-3
Online ISBN: 978-3-662-22505-9
eBook Packages: Springer Book Archive