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Presentation of Tumor Antigens by Langerhans Cells and Other Dendritic Cells

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The Immune Functions of Epidermal Langerhans Cells

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

It has long been disputed whether human or animal tumors carry immunogenic epitopes on their surface that allow for recognition and destruction of tumor cells by the host’s immune system. Whereas earlier studies concluded that experimentally induced tumors are often immunogenic, while spontaneously arising neoplasms lack antigenic epitopes, it is now generally accepted that many spontaneously arising malignancies also carry immunogenic epitopes on their cell surfaces. In the clinical situation, the immunogenicity of some tumors—especially in the case of melanoma—is evident by their infiltration with leukocytes as well as by the phenomenon of spontaneous partial or complete tumor regression. In vitro, tumor-specific cytotoxic T lymphocyte (CTL) activity and cytokine secretion of T cells after coculture with tumor targets has been shown for human primary and metastatic melanoma, and both CD4+ and CD8+ tumor-infiltrating lymphocytes have been cloned.1,2 Furthermore, the exact peptide sequences of some of these melanoma antigens are known (Table 9.1).3,4 Thus, at least with regard to some cutaneous neoplasms, there is formal proof that they can be immunostimulatory.

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Authors
  1. Stephan Grabbe
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  2. Richard D. Granstein
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© 1995 Springer-Verlag Berlin Heidelberg

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Grabbe, S., Granstein, R.D. (1995). Presentation of Tumor Antigens by Langerhans Cells and Other Dendritic Cells. In: The Immune Functions of Epidermal Langerhans Cells. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22497-7_9

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  • DOI: https://doi.org/10.1007/978-3-662-22497-7_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22499-1

  • Online ISBN: 978-3-662-22497-7

  • eBook Packages: Springer Book Archive

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