Ultraviolet Radiation-Mediated Defects in Langerhans Cell Function

  • Paul R. Bergstresser
  • Akira Takashima
Part of the Medical Intelligence Unit book series (MIU.LANDES)


Skin, after exposure to sunlight, exhibits a sequence of predictable changes, including redness (erythema), immediate pigment darkening and tanning, followed later by premature aging and cancer. Although electromagnetic radiation that reaches the earth contains a spectrum of energies, ranging from ultraviolet (UV) to infrared, it is UV radiation in spectrum B (UVB: 290–320 nm) and spectrum A (UVA: 320–400 nm) that are responsible for the majority of these changes. On the other hand, UVA and UVB radiation are unequal in their capacities to affect skin. Specifically, UVB is more efficient in producing erythema and cancer, whereas UVA is the primary cause of immediate pigment darkening and aging.1


Contact Hypersensitivity Urocanic Acid Clonal Anergy Drain Lymph Node Cell Dendritic Cell Line 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Paul R. Bergstresser
  • Akira Takashima

There are no affiliations available

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