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Langerhans Cell Migration: Initiation and Regulation

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The Immune Functions of Epidermal Langerhans Cells

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

Abstract

Langerhans cells (LC) form a contiguous network within the epidermis. It was proposed by Shelley and Juhlin in 19761 that LC represent a trap for external antigens at skin surfaces and since then the role of these cells in cutaneous immune surveillance has excited considerable interest.2 The theory is that LC act as sentinels of the immune system, sampling the external environment and relaying signals from a potentially hostile antigenic environment to the draining lymph nodes. This phenomenon has been studied extensively within the context of skin sensitization to chemical allergens. In its simplest form the proposal is that following skin sensitization the chemical allergen will associate with resident LC which are then induced to migrate from the skin, via afferent lymphatics, and transport antigen to the draining nodes. To a large extent this sequence of events has been borne out by experimentation.

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Authors
  1. Ian Kimber
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  2. Marie Cumberbatch
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© 1995 Springer-Verlag Berlin Heidelberg

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Kimber, I., Cumberbatch, M. (1995). Langerhans Cell Migration: Initiation and Regulation. In: The Immune Functions of Epidermal Langerhans Cells. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22497-7_7

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  • DOI: https://doi.org/10.1007/978-3-662-22497-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22499-1

  • Online ISBN: 978-3-662-22497-7

  • eBook Packages: Springer Book Archive

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