Abstract
The importance of cytokines for the induction of immune responses has been demonstrated in various systems for numerous cell types. In skin, keratinocytes serve as rich sources of various cytokines (interleukin (IL) 1, IL-3, IL-6, IL-7, IL-8, IL-10, IL-12, etc.) and growth factors (granulocyte/macrophage colony-stimulating factor (GM-CSF), etc.) known to be important for the induction and inhibition of inflammatory reactions, thereby providing a basis for the highly varied reaction patterns of the “skin immune system.”1 Indeed the complexity of epidermal cytokine production has been demonstrated, especially for the induction of different cytokines by ultraviolet (UV) light and in inflammatory skin diseases such as psoriasis or atopic dermatitis, as well as contact dermatitis.
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References
Luger TA, Schwarz T, eds. Epidermal Cytokines and Growth Factors. New York: Marcel Dekker, 1993.
Heufler C, Koch F, Schuler G. GM-CSF and IL-1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory cells. J Exp Med 1988; 167: 700–5.
Witmer-Pack MD, Olivier W, Valinsky J et al. GM-CSF is essential for the viability and function of cultured murine epidermal Langerhans cells. J Exp Med 1987; 166: 1484–95.
Landsteiner K, Chase MW. Experiments on the transfer of cutaneous sensitivity to single chemical compounds. Proc Soc Exp Biol Med 1942; 49: 688–94.
Macher E, Chase MW. Studies on the sensitization of animals with simple chemical compounds. XI. The fate of labeled picryl chloride and DNCB after sensitizating injections. J Exp Med 1969; 129: 81–102.
Macher E, Chase MW. Studies on the sensitization of animals with simple chemical compounds. XII. The influence of the excision of allergic depots on onset of delayed hypersensitivity and tolerance. J Exp Med 1969; 129: 103–18.
Sulzberger MB. Arsphenamine hypersensitiveness in guinea pigs. Arch Derm Syph 1930; 22: 839–58.
Haftek M. Langerhans cells in cutaneous pathology. In: Thivolet J, Schmitt D, eds. The Langerhans Cell. Libbey Eurotext 1988; 172: 377–85.
Macatonia SE, Knight SC, Edwards AJ et al. Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies. J Exp Med 1987; 166: 1654–67.
Silberberg I, Baer R, Rosenthal AS. The role of Langerhans cells in allergic contact dermatitis. A review of findings in man and guinea pigs. J Invest Dermatol 1976; 66: 210–7.
Aiba S, Katz SI. Phenotypic and functional characterization of in vivo-activated LC. J Immunol 1990; 145: 2791–6.
Luger TA. Epidermal cytokines. Acta Derm Venereol 1989; 69: 61–7.
Enk AH, Katz SI. Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci USA 1992; 89: 1398–1402.
Enk AH, Angeloni VL, Udey MC et al. An essential role for Langerhans cell-derived IL-113 in the induction of primary immune responses in skin. J Immunol 1993; 150: 3698–704.
Nylander Lundqvist E, Bäck O. Interleukin-1 decreases the number of Ia’ epidermal dendritic cells but increases their expression of la antigen. Acta Derm Venereol 1990; 70: 391–8.
Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Thl clones. J Exp Med 1989; 170: 2081–95.
Moore KW, Vieira P, Fiorentino DF et al. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 1990; 248: 1230–4.
Enk AH, Katz SI. Identification and induction of keratinocyte-derived IL-10. J Immunol 1992; 149: 92–5.
Rivas JM, Ullrich SE. Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. J Immunol 1992; 149: 3865–71.
Enk AH, Angeloni VL, Udey MC et al. Inhibition of LC-APC function by IL-10. A role for IL-10 in induction of tolerance. J Immunol 1993; 151: 2390–7.
Bretscher PA, Cohn M. A theory of self-nonself discrimination. Science 1970; 163: 1042–9.
Schwartz RH. Acquisition of immunologic self-tolerance. Cell 1989; 57: 1073–5.
Enk AH, Saloga J, Becker D et al. Induction of hapten-specific tolerance by IL-10 in vivo. J Exp Med 1994; 179: 1397–1402.
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Enk, A.H., Katz, S.I. (1995). The Role of Interleukin-1β and Interleukin-10 in Langerhans Cell-Mediated Immune Responses. In: The Immune Functions of Epidermal Langerhans Cells. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22497-7_4
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DOI: https://doi.org/10.1007/978-3-662-22497-7_4
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