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Human Langerhans Cells Derived from CD34+ Blood Precursors: Mode of Generation, Phenotypic and Functional Analysis, and Experimental and Clinical Applicability

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The Immune Functions of Epidermal Langerhans Cells

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

Epidermal Langerhans cells (LC) were originally described in 1868 as nerve cells within human skin.1 After more than a century of speculations about their origin,2,3 they were finally recognized to be hematopoietic cells as evidenced by their uniform expression of the panhematopoietic marker CD45 and by the presence of donor-derived phenotypic features on LC of H-2–disparate murine4,5 and sex-mismatched human6 bone marrow chimeras.

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Authors
  1. Dirk Strunk
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  2. Georg Stingl
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Strunk, D., Stingl, G. (1995). Human Langerhans Cells Derived from CD34+ Blood Precursors: Mode of Generation, Phenotypic and Functional Analysis, and Experimental and Clinical Applicability. In: The Immune Functions of Epidermal Langerhans Cells. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22497-7_2

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  • DOI: https://doi.org/10.1007/978-3-662-22497-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22499-1

  • Online ISBN: 978-3-662-22497-7

  • eBook Packages: Springer Book Archive

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