Abstract
Human beings become infected with protozoan parasites of the genus Leishmania when an infected female sandfly is probing for blood. Thus, the skin is the parasite’s site of entry into the mammalian host, where it exists in the obligatory intracellular form and resides in mononuclear phagocytes. The infection presents as a large variety of disease manifestations differing markedly in their severity. In cutaneous leishmaniasis, the infection may be asymptomatic or it may result in clinical symptoms ranging from self-healing localized ulcers to uncontrolled diffuse cutaneous lesions. The pathological changes that characterize the various forms of the disease reflect the balance between parasite multiplication, the immune response of the host and the resultant degenerative changes.1
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Moll, H., Flohé, S., Blank, C. (1995). Langerhans Cells in Cutaneous Leishmaniasis. In: The Immune Functions of Epidermal Langerhans Cells. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22497-7_10
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DOI: https://doi.org/10.1007/978-3-662-22497-7_10
Publisher Name: Springer, Berlin, Heidelberg
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