The Use of Cerebroside Synthase Inhibitors as Probes for Assessing the Metabolism and Function of Sphingolipids
Although sphingolipids have been the object of active investigation for over 50 years, the intensity of interest in these ubiquitous lipids has increased recently. This interest is the result of two significant developments. First, several agonists have been identified as effectors of sphingolipid metabolism. Second, several critical cellular functions have been associated with sphingolipid products, consistent with the view that sphingolipids have distinct second messenger functions.
KeywordsMDCK Cell Heat Shock Response Small Heat Shock Protein Sphingoid Base Sphingolipid Metabolism
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