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Ceramide and Inflammation

  • Chapter
Sphingolipid-Mediated Signal Transduction

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Inflammation is a general term used to describe an extraordinarily complex set of bio-chemical events mounted by living tissues either in response to physical injury or as part of the host-defense mechanism. The pain, swelling, heat, and redness characteristic of inflammation involves an extensive network of cellular and molecular interactions. These cornplex interactions are characterized by the infiltration of inflammatory cells (e.g., neutrophils, mononuclear leukocytes and macrophages) to the site of injury and/or invasion and the generation of an almost unimaginable array of biologically active molecules by both infiltrating and resident cells, which function as the primary biochemical mediators of the inflammatory response; (please see the scheme depicting the interactions of a variety of different types of cells involved in inflammation). These inflammatory mediators include a wide variety of soluble molecules such as vaso- and neuroactive peptides, lipid mediators such as the eicosanoids, and growth factors and cytokines which are generated in response to specific inflammatory stimuli. Adding to the overall complexity of this soluble mediator signaling network is the fact that several of the proinflammatory cytokines may elicit differential biologic effects on different cell types, induce overlapping responses, have synergistic or antagonistic effects on one another, or affect the synthesis of other cytokines. Thus, in addition to their respective roles in the inflammatory process, many of these soluble mediators play important roles in the regulation of other physiologically important processes such as modulation of the immune response, cell-cell interaction and adhesion, apoptosis, cell growth and differentiation, to mention only a few.

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Authors
  1. Leslie R. Ballou
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© 1997 Springer-Verlag Berlin Heidelberg

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Ballou, L.R. (1997). Ceramide and Inflammation. In: Sphingolipid-Mediated Signal Transduction. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22425-0_3

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  • DOI: https://doi.org/10.1007/978-3-662-22425-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22427-4

  • Online ISBN: 978-3-662-22425-0

  • eBook Packages: Springer Book Archive

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