Abstract
Many bacterial pathogens of man pass through several different environments before coming into contact with and colonizing the host. These may include another mammal (zoonotic infection), insects (arthropod-borne infections), or specific niches in the terrestrial or aquatic ecosystems, e.g. contaminated food or water. Even after gaining access to a host, a pathogen often passes through several different environments before reaching the site it will ultimately colonize. Thus, for most bacterial pathogens one can imagine a life cycle which consists of a segment outside the host and a segment within the host, the latter which can be subdivided into the various anatomical sites through which the organism passes on its way to the site of colonization.
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O’Connell, C.M.C., Sandlin, R.C., Maurelli, A.T. (1995). Signal Transduction and Virulence Gene Regulation in Shigella spp.: Temperature and (maybe) a Whole Lot More. In: Signal Transduction and Bacterial Virulence. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22406-9_8
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DOI: https://doi.org/10.1007/978-3-662-22406-9_8
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