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Regulation of Virulence in Vibrio Cholerae by the ToxR System

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Signal Transduction and Bacterial Virulence

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

The bacterium Vibrio cholerae causes the human diarrheal disease called cholera. The primary virulence determinant in this pathogen is the cholera toxin, and studies of toxin biogenesis as well as its effects on eukaryotic cells have contributed a great deal to our understanding of fundamental questions in molecular and cellular biology. In addition, V. cholerae has become a model organism for studying mucosal pathogenesis and immunity. Work originally aimed at developing toxoid or live oral vaccine preparations to protect susceptible populations against cholera has led to the general question of how toxin and other virulence factors are regulated in V. cholerae, which is the subject of this chapter.

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Authors
  1. Victor J. DiRita
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© 1995 Springer-Verlag Berlin Heidelberg

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DiRita, V.J. (1995). Regulation of Virulence in Vibrio Cholerae by the ToxR System. In: Signal Transduction and Bacterial Virulence. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22406-9_6

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  • DOI: https://doi.org/10.1007/978-3-662-22406-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22408-3

  • Online ISBN: 978-3-662-22406-9

  • eBook Packages: Springer Book Archive

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