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PhoP/PhoQ: Regulating Salmonella Adaptation to Host Microenvironments

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Signal Transduction and Bacterial Virulence

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

Abstract

Salmonella serotypes can colonize and infect an enormous range of vertebrate hosts after orally ingestion. Infection results in a wide spectrum of acute and chronic illnesses; including gastroenteritis, enteric (typhoid) fever, and bacteremia.1 The consequence of Salmonellae ingestion by vertebrates depends on the serotype. Certain Salmonella serotypes have very narrow host specificity while others infect a wide variety of animal hosts.1 Examples of host-specific serotypes include S. typhi (man), S. pullorum (fowl), and S. arizonae (reptiles). Such serotypes, with rare exceptions, are only pathogenic for a specific host. In contrast S. typhimurium infects a wide variety of hosts, though disease manifestation varies. In immunocompetent humans an acute self limited gastroenteritis is seen after S. typhimurium ingestion, while in mice a systemic illness similar to human enteric fever occurs. In addition host immune status dramatically alters disease outcome. Humans with the acquired immunodeficiency syndrome (AIDS) are highly susceptible to severe systemic infection with S. typhimurium2 and the susceptibility of inbred mice to this serotype varies widely as a result of mutations that alter immune function.3,4

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© 1995 Springer-Verlag Berlin Heidelberg

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Miller, S.I. (1995). PhoP/PhoQ: Regulating Salmonella Adaptation to Host Microenvironments. In: Signal Transduction and Bacterial Virulence. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22406-9_5

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  • DOI: https://doi.org/10.1007/978-3-662-22406-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22408-3

  • Online ISBN: 978-3-662-22406-9

  • eBook Packages: Springer Book Archive

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