Aldosterone and alterations in circulatory reactivity following endotoxins
The pituitary-adrenocortical system and the sympathetic nervous system with the adrenal medulla are involved in the adaptation of the organism to any form of injury, including responses to endotoxins Changes in the concentrations of corticosteroids and catecholamines in response to an endotoxin have been noted (for references see 4, 5, 6, 8, 9, 10, 12). However, it is not yet known to what extent the fluctuations observed in the concentrations of the adrenal hormones are directly responsible for the consequences and course of endotoxin intoxication.
KeywordsPressor Response Lethal Dose Adrenal Medulla Adrenal Hormone Altered Reactivity
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- 1.Abernathy, R. S., and W. W. Spink: Proc. Soc. Exper. Biol. Med. (U. S. A.) 95, 580 (1957).Google Scholar
- 5.HÖKfelt, B.: See the present volume, p. 151.Google Scholar
- 8.Melby, J. C., I. C. Bossenmaier, R. H. Egdahl, and W. W. Spinx: Lancet (G. B.) 1959/I, 441.Google Scholar
- 9.Nykiel, F., and V. V. Glaviano: J. Appl. Physiol. (U. S. A.) 16, 348 (1961).Google Scholar
- 10.Pekkarinen, A.: The Biochemical Response to Injury. p. 217. Oxford: Blackwell 1960.Google Scholar
- 11.Tauber, H., and W. Garson: Proc. Soc. Exper. Biol. Med. (U. S. A.) 97, 886 (1958).Google Scholar
- 12.Walton, R. P., J. A. Richardson, R. P. Walton JR., and W. L. Thompson: Amer. J. Physiol. 197, 223 (1959).Google Scholar