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Structure and Assembly of the Channel-Forming Aeromonas Toxin Aerolysin

  • Chapter
Protein Toxin Structure

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Aeromonas hydrophila is a water-borne Gram-negative bacterium associated with gastroenteritis and opportunistic infections.1 The organism secretes a protein toxin called aerolysin that appears to be a major virulence factor of the bacterium.2 The toxin is synthesized as a preproprotein with a typical signal sequence that is removed during transit across the inner membrane of the Aeromonas bacterium.3 The protoxin then appears to fold and dimerize in the periplasm and leaves the cell in a separate step that requires a group of more than 14 genes of the General Secretory Pathway.4,5

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Authors
  1. Michael W. Parker
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  2. J. Thomas Buckley
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  3. F. Gisou van der Goot
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  4. Demetrius Tsernoglou
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© 1996 Springer-Verlag Berlin Heidelberg

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Parker, M.W., Buckley, J.T., van der Goot, F.G., Tsernoglou, D. (1996). Structure and Assembly of the Channel-Forming Aeromonas Toxin Aerolysin. In: Protein Toxin Structure. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22352-9_5

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  • DOI: https://doi.org/10.1007/978-3-662-22352-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22354-3

  • Online ISBN: 978-3-662-22352-9

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