Plasma Amino Acid Concentrations in Cancer Cachexia

  • Steven Hochwald
  • Martin Heslin
Part of the Medical Intelligence Unit book series (MIU.LANDES)


Cancer cachexia is characterized by alterations in a variety of metabolic processes. These include changes in the rates of gluconeogenesis, protein synthesis, and oxidative catabolism.1−4 Since circulating amino acids serve as substrates for all these processes, studies involving the characterization of the concentration of plasma free amino acids in cancer patients is of interest. In addition, studying patterns of plasma amino acid variations might provide information concerning the derangement in metabolism occurring in certain tumor types and with progressive illness.


Amino Acid Metabolism Cancer Group Branch Chain Amino Acid Amino Acid Concentration Cancer Cachexia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Jeevanandam M, Lowry SF, Horowitz GD, Brennan MF. Cancer cachexia and protein metabolism. Lancet 1984; 1: 1423–6.PubMedCrossRefGoogle Scholar
  2. 2.
    Norton JA, Stein TP, Brennan MF. Whole body-protein synthesis and turnover in normal man and malnourished patients with and without known cancer. Ann Surg 1981; 194: 123–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Tayek JA. A review of cancer cachexia and abnormal glucose metabolism in humans with cancer. J Am Coll Clin Nutr 1992; 11 (4): 445–56.Google Scholar
  4. 4.
    Waterhouse C. Oxidation and metabolic interconversion in malignant cachexia. Cancer Treat Rep 1981; 65: 61–6.PubMedGoogle Scholar
  5. 5.
    Adibi SA. Influence of dietary deprivations on plasma concentration of free amino acids of man. J Appl Physiol 1968; 25 (1): 52–7.PubMedGoogle Scholar
  6. 6.
    Felig P, Owen 0E, Wahren J, Cahill GF. Amino acid metabolism during prolonged starvation. J Clin Invest 1969; 48: 584–94.PubMedCrossRefGoogle Scholar
  7. 7.
    Holt LE, Synderman SE, Norton PM, Roitman E, Finch J. The plasma aminogram in kwashiorkor. Lancet 1963; 2: 1343–8.CrossRefGoogle Scholar
  8. 8.
    Saunders SJ, Truswell AS, Barbezat GO, Wittman W, Hansen JDL. Plasma free amino acid pattern in protein-calorie malnutrtion. Lancet 1967; 2: 795–7.PubMedCrossRefGoogle Scholar
  9. 9.
    Smith SR, Pozefsky T, Chhetri MK. Nitrogen and amino acid metabolism in adults with protein-calorie malnutrition. Metabolism 1974; 23 (7): 603–18.PubMedCrossRefGoogle Scholar
  10. 10.
    Swendseid ME, Yamada C, Vinyard E, Figueroa WG. Plasma amino acid levels in young subjects receiving diets containing 14 or 3.5g nitrogen per day. Am J Clin Nutr 1968; 21: 1381–3.PubMedGoogle Scholar
  11. 11.
    Chung W, Bauer JM. A study of free amino acids and of glutamine synthesis in tumor-bearing rats. Cancer Research 1959; 20: 848–57.Google Scholar
  12. Sassenrath EN, Greenberg DM. Tumor-host relationships. I. Effects on free amino acid concentrations of certain tissues. Cancer Research 1954; 14:563–9.Google Scholar
  13. 13.
    Arbeit J, Gorschboth CM, Brennan MF. Basal amino acid concentrations and the response to incremental glucose infusion in tumor-bearing rats. Cancer Research 1985; 45: 6296–300.PubMedGoogle Scholar
  14. 14.
    Popp MB, Morison SD, Brennan MF. Total parenteral nutrition in a methylcholanthrene induced rat sarcoma model. Cancer Treat Rep 1981; 65 (Suppl 5): 137–43.PubMedGoogle Scholar
  15. 15.
    Burt ME. Metabolic alterations in a rat methylcholanthrene-induced sarcoma model. PhD Thesis 1980; 61–4.Google Scholar
  16. 16.
    Clarke EF, Lewis AM, Waterhouse C. Peripheral amino acid levels in patients with cancer. Cancer 1978; 42: 2909–13.PubMedCrossRefGoogle Scholar
  17. 17.
    Burt ME, Aoki TT, Gorschboth BS, Brennan MF. Peripheral tissue metabolism in cancer-bearing man. Ann Surg 1983; 198 (6): 685–91.PubMedCrossRefGoogle Scholar
  18. 18.
    Levin L, Gevers W, Jardine L, DeGuel FJM, Duncan EJ. Serum amino acids in weight-losing patients with cancer and tuberculosis. Eur J Cancer Clin Oncol 1983; 19 (6): 711–5.PubMedCrossRefGoogle Scholar
  19. 19.
    Bennegard K, Lindmark L, Eden E, Svaninger G, Lundholm K. Flux of amino acids across the leg in weight-losing cancer patients. Cancer Research 1984; 44: 386–93.PubMedGoogle Scholar
  20. 20.
    Ching N, Grossi C, Gulab J et al. Plasma amino acid and serum unesterified fatty acid deficits and the effect of nutritional support in chemotherapy treatment. Surgery 1984; 95 (6): 730–7.PubMedGoogle Scholar
  21. 21.
    Norton JA, Gorschboth CM, Wesley RA, Burt ME, Brennan MF. Fasting plasma amino acid levels in cancer patients. Cancer 1985; 56: 1181–6.PubMedCrossRefGoogle Scholar
  22. 22.
    Naini AB, Dickerson JWT, Brown MM. Preoperative and postoperative levels of plasma protein and amino acid in esophageal and lung cancer patients. Cancer 1988; 62: 355–60.PubMedCrossRefGoogle Scholar
  23. 23.
    Pisters PW, Cersosimo E, Rogatko A, Brennan MF. Insulin action on glucose and brached-chain amino acid metabolism in cancer cachexia: Differential effects of insulin. Surgery 1992; 111: 301–10.PubMedGoogle Scholar
  24. 24.
    Zhang PC, Pang CP. Plasma amino acid patterns in cancer. Clinical Chemistry 1992; 38 (6): 1198–9.PubMedGoogle Scholar
  25. 25.
    Bozzetti F, Migliavacca S, Scotti A et al. Impact of cancer, type, site, stage and treatment on nutritional status of patients. Ann Surg 1982; 196 (2): 170–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Steven Hochwald
  • Martin Heslin

There are no affiliations available

Personalised recommendations