Biophysical and Biochemical Properties of the p53 Protein

  • Tapas Mukhopadhyay
  • Steven A. Maxwell
  • Jack A. Roth
Part of the Molecular Biology Intelligence Unit book series (MBIU)


The biochemical mechanism of p53 in the control of cell growth is not completely understood. Considerable evidence implicates regulation of gene transcription as a mechanism of p53 action in controlling cell growth. The protein does resemble a transcription factor1–5 in that it has an acidic domain that can transactivate reporter genesG6–12 and a basic carboxyl terminal domain that can bind nonspecifically to DNA13 (Fig. 4.1).


Marrow Blast Cell Conformational Domain Monoclonal Antibody PAb240 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Tapas Mukhopadhyay
    • 1
  • Steven A. Maxwell
    • 1
  • Jack A. Roth
    • 1
  1. 1.M. D. Anderson Cancer CenterUniversity of TexasHoustonUSA

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