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Biophysical and Biochemical Properties of the p53 Protein

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p53 Suppressor Gene

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

The biochemical mechanism of p53 in the control of cell growth is not completely understood. Considerable evidence implicates regulation of gene transcription as a mechanism of p53 action in controlling cell growth. The protein does resemble a transcription factor1–5 in that it has an acidic domain that can transactivate reporter genesG6–12 and a basic carboxyl terminal domain that can bind nonspecifically to DNA13 (Fig. 4.1).

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  1. M. D. Anderson Cancer Center, University of Texas, Houston, Texas, USA

    Tapas Mukhopadhyay Ph.D., Steven A. Maxwell Ph.D. & Jack A. Roth M.D.

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  1. Tapas Mukhopadhyay Ph.D.
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  2. Steven A. Maxwell Ph.D.
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© 1995 Springer-Verlag Berlin Heidelberg

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Mukhopadhyay, T., Maxwell, S.A., Roth, J.A. (1995). Biophysical and Biochemical Properties of the p53 Protein. In: p53 Suppressor Gene. Molecular Biology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22275-1_4

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  • DOI: https://doi.org/10.1007/978-3-662-22275-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22277-5

  • Online ISBN: 978-3-662-22275-1

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