Challenges and Opportunities in New Drug Development
In the 18th century, mercury was the treatment of choice for syphilis.1 Mercury was so commonly used, in fact, that physicians rarely saw a patient who had not taken it, even though it was eventually proven ineffective.2 As a result, it was virtually impossible to separate the effects of the disease from the treatment. Many physicians even insisted that mercury had no toxic effects.
KeywordsToxicity Lymphoma Leukemia Retina Oncol
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- 1.Mathias A. The Mercurial Disease: an inquiry into the history and nature of the disease produced in the human condition by the use of mercury. 3rd ed. London: J. Callow, 1866.Google Scholar
- 2.Goldwater LJ. Mercury: a History of Quicksilver. Baltimore: York Press, 1972.Google Scholar
- 3.Hacker MP, Lazo JS, Tritton TR. Organ directed toxicities of anticancer drugs. Boston: Martinus Nijhoff Publishing, 1987.Google Scholar
- 5.Perry MC, Yarbro JW. Toxicity of chemotherapy. Orlandlo: Grune and Stratton, 1984.Google Scholar
- 13.Von Hoff DD, Casper J, Bradley E et al. Association between human tumor colony forming assay results and response of an individual patient’s tumor to chemotherapy. Am J Med 1981; 70: 1047.Google Scholar
- 14.Von Hoff DD, Clark GM, Stogdill BJ et al. Prospective clinical trial of a human tumor cloning system. Cancer Res 1983; 3: 1926–31.Google Scholar
- 15.Boyd MR, Paull KD, Rubinstein LR. Data display and analysis strategies for the NCI disease-oriented in vitro antitumor drug screen. In: Valeriote FA, Corbett T, Baker L, eds. Cytotoxic anticancer drugs: models and concepts for drug discovery and development. Amsterdam: Kulwer Academic Publishers, 1992; 11–34.CrossRefGoogle Scholar
- 16.Boyd MR. The future of new drug development. In: Niederhubr JE, ed. Current therapy in oncology. Philadelphia: BC Decker Inc., 1993; 11–22.Google Scholar
- 17.Grever MR, Hollingshead MG, Alley MC et al. Status of in vivo evaluations in the NCI anticancer drug discovery program. Proc Am Assoc Cancer Res 1994; 35: 369.Google Scholar
- 23.Boyd MR. Status of the NCI preclinical antitumor drug discovery screen. In: Devita VT Jr, Hellman S, Rosenberg SA, eds. Cancer: principle and practice of oncology updates. Philadelphia: JP Lippincott, 1989; 3: 1–12.Google Scholar