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Die Erzeugung von Harnsteinen im Tierversuch

  • Helmut Haase
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 16 / 4)

Zusammenfassung

Die Entwicklung von Verfahren zur Harnsteinerzeugung im Tierversuch begann — wenn man von einem Einzelversuch in der ersten Hälfte des 18. Jahrhunderts (Nuck, 1723) absieht — kurz vor Beginn des 20. Jahrhunderts. Methodisch ging man dabei so vor, daß Fremdkörper in die Blase oder das Nierenbecken implantiert wurden. Nach einer gewissen Zeit wurden dann Ausmaß und chemische Beschaffenheit der Auflagerungen registriert. Etwa seit 1920 wandte man sich auch anderen Verfahren zu, wobei mehr und mehr neue Methoden der experimentellen Chirurgie, der Ernährungsphysiologie, der Histologie, Bakteriologie, Biochemie u. a. Fachgebiete einbezogen und für die speziellen Aufgaben der Harnsteinforschung modifiziert wurden.

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Literatur

  1. Abeshouse, B. S., and T. Weinberg: Experimental study of solvent action of versene on urinary calculi. J. Urol. (Baltimore) 65, 316 (1951).Google Scholar
  2. Andrus, S. B., S. N. Gershoff, F. F. Faragalla and E. L. Prien: Production of calcium-oxalate renal calculi in vitamin B6-deficient rats. Lab. Invest. 9, 7 (1960).PubMedGoogle Scholar
  3. Antopol, W.: Experimental aspects of sulfapyridine urolithiasis. Arch. Path. (Chicago) 30, 985 (1940).Google Scholar
  4. Antopol, W., D. Lehr, J. Churg and H. Sprinz: Changes in the urinary tract and other organs after administration of three sulfanilamide derivates. Arch. Path. (Chicago) 31, 592 (1941).Google Scholar
  5. Antopol, W., and H. Robinson: Urolithiasis and renal pathology after oral administration of sulfa-pyridine. Proc. Soc. exper. Biol. (N. Y.) 40, 428 (1939).Google Scholar
  6. Augustin, E.: Tierexperimentelle Untersuchungen zur Frage von Entstehung und Lokalisation von Nierenschädigungen nach Sulfonamidmedikation Arch. Gynäk. 179, 220, 311, 401 (1951).Google Scholar
  7. Barnes, L. L.: The deposition of calcium in the hearts and kidneys of rats in relation to age, source of calcium, exercise and diet. Amer. J. Path. 18, 41 (1942).PubMedGoogle Scholar
  8. Barraquer, J., u. J. Escribano: Nierensteine im Verlaufe von Behandlungen mit Azetazolamid. Rev. clin. esp. 64, 310 (1957).PubMedGoogle Scholar
  9. Becker, B., and W. H. Middletown: Long-term acetazoleamide (Diamox) administration in therapy of glaucomas. Arch. Ophthal. (Chicago) 54, 187 (1955).Google Scholar
  10. Beeson, W. N., J. W. Pence and G. C. Holm: Urinary calculi in sheep. Amer. J. vet. Res. 4, 120 (1943).Google Scholar
  11. Beidlemann, B.: Treatment of chronic hyperparathyroidism. Metabolism 7, 690 (1958).Google Scholar
  12. Benjamin, J. A., J. G. Wilson and A. D. Leahy: Study of experimental urinary calculi: II. Quantitative microchemical, spectrographic, and citric acid analysis of albino rat calculi, with a preliminary apatite report. J. Urol. (Baltimore) 54, 516 (1945).Google Scholar
  13. Bernhard, K.: Zum Problem der Nierensteinbildung. Dtsch. med. J. 7, 438 (1956).Google Scholar
  14. Bliss, A. R., G. R. Livermore and E. O. Prather: The relation of vitamin A and vitamin D to urinary calculus formation. J. Urol. (Baltimore) 30, 639 (1933).Google Scholar
  15. Bollman, J. L., and F. C. Mann : Studies on physiology of the liver. Xxv : Allantoin and uric acid following total removal of the liver. Amer. J. Physiol. 104, 242 (1933).Google Scholar
  16. Bollman, J. L., F. C. Mann and T. B. Magath: Studies on the physiology of the liver. X: Uric acid following total removal of the liver. Amer. J. Physiol. 72, 629 (1925).Google Scholar
  17. Bollman, J. L., F. C. Mann and T. B. Magath:Boning, M.: Experimentelle Urolithiasis durch bakterielle Infektion. Arch. ital. Urol. 18, 320 (1941).Google Scholar
  18. Boshamer, K.: Behandlungsergebnisse bei der klinisch beobachteten Nierensteinkrise. Therapiewoche 1, 406 (1951).Google Scholar
  19. Boshamer, K.: Klinische Untersuchungen zur Harnsteinbildung. Z. Urol. 48, 193 (1955).PubMedGoogle Scholar
  20. Boshamer, K.: Formalgenese der Harnsteine; Verh. Ber. Symposion Jan. 58, Köln. Basel: S. Karger 1959.Google Scholar
  21. Boshamer, K.: Morphologie und Genese der Harnsteine; in Handbuch der Urologie, Bd. 10. BerlinGöttingen-Heidelberg: Springer-Verlag 1961.Google Scholar
  22. Bradford, R. H., R. P. Howard, W. Joel and M. R. Shetlar: Antagonistic effects of parathyroid extracts and cortisone. Effects on serum protein and glycoprotein fraction and on renal calcification. A. M. A. Arch. Path. 69, 382 (1960).Google Scholar
  23. BRÉChot et Pergola: Ostéite fibro-kystique expérimental par injection de parathormone chez le lapin. Bull. Soc. nat. chir. 59, 346 (1933).Google Scholar
  24. Briggs, A. P.: Some applications of the colorimetric phosphate method. J. biol. Chem. 59, 255 (1924).Google Scholar
  25. Brinkmann, W.: Die Konkrementbildungskrise und ihre BeeinfluBbarkeit durch Hyaluronidase im Tierexperiment. Z. Urol. 48, 337 (1955).PubMedGoogle Scholar
  26. Brodersen, O.: Hyperparathyroidisme et calculs du rein. Med. Rev. (Bergen) 52, 529 (1935).Google Scholar
  27. Brosig, W., u. H. H. Hirsch* Glukonsäure zur Steinprophylaxe. Z. Urol. 50, 304 (1957).Google Scholar
  28. Brubacher, G., M. Just, H. Bodur u. K. Bernhard: Zur Biochemie der Oxalsäure. II. Ausscheidung und Retention injizierter 1,2–14C-Oxalsäure bei normalen, rachitischen und alloxan-diabetischen Ratten. Hoppe-Seilers Z. physiol. Chem. 305, 248 (1956).Google Scholar
  29. Tikofer, P.: Über die Abhängigkeit der Urolithiasis nach Sulfanilamiden vom pH des Harnes. Praxis 34, 78 (1945).Google Scholar
  30. Burns, E. L., and J. R. Schenken: Quantitative studies on relationship between estrogen and mammary gland carcinoma in strain C311 mice. Proc. Soc. exp. Biol. (N. Y.) 43, 608 (1940).Google Scholar
  31. Burrows, H.: Pathological conditions induced by estrogenic compounds in the coagulating gland and prostate of the mouse. Amer. J. Physiol. 23, 490 (1935).Google Scholar
  32. Burrows, H.:, and N. M. Kennaway: On some effects produced by applying oestrin to skin of mice. Amer. J. Cancer 20, 48 (1934).Google Scholar
  33. Butt, A. J.: Historical survey of etiologic factors in renal lithiasis: In A. J. Butt: Etiologic factors in renal lithiasis; S. 3. Springfield, Illinois, Usa: Charles C. Thomas-Publisher 1956.Google Scholar
  34. Calhoun, W. K., R. B. Jennings and W. B. Bradley: Calcium oxalate excretion and hematuria in vitamin B6-deficient rats fed phthalylsulfathiazole. J. Nutr. 67, 237 (1959).PubMedGoogle Scholar
  35. Care, A. D., and G. Whson: The prevention of vesical calculi in rats by the oral administration of polysodium metaphosphate. Clin. Sci. 15, 183 (1956).PubMedGoogle Scholar
  36. Chakravarti, H. S., and R. Banerjee: Experimental urolithiasis in rat with foreign body in the bladder and role of infection in its production. J. Urol. (Baltimore) 78, 785 (1958).Google Scholar
  37. Chiray, M., L. Justin-BesanÇON, G. Albot et I. Dieryck: Aspects histologiques de la lithiase oxalique expérimentale par l’ethylène glycol. Ann anat. path. 16, 393 (1939).Google Scholar
  38. Chown, B., M. Lee, J. Teal and R. Currie: The experimental production of nephritis in rats by means of parathyroid hormone and of vitamin D. J. Path. Bact. 49, 273 (1939).Google Scholar
  39. Chute, R.: The vital importance of the relation of hyperparathyroidism to the formation of certain urinary calculi and its remedy. New Engl J Med. 210, 1251 (1934).Google Scholar
  40. CLÉMent, R.: Les causes de récidive des calculs rénaux. Presse méd. 48, 328 (1940).Google Scholar
  41. Collica, J.: New concept of the pathogenesis of urinary lithiasis. Amer. J. Surg. 76, 424 (1948).PubMedGoogle Scholar
  42. Coox, E. N., and F. R. Heating : Calculs du rein associés à l’hyperparathyroidie. J. Tirol. (Baltimore) 54, 525 (1949).Google Scholar
  43. Cordonnier, J. J., and J. A. Miller: The relationship between alkaphosphatase in the kidney and urinary calculi. J. Urol. (Baltimore) 66, 12 (1951).Google Scholar
  44. Corsten, M.: Überblick über die Sulfonamidschäden nebst kasuistischen Beiträgen. Med. Mschr. 4, 508 (1950).PubMedGoogle Scholar
  45. Cox, W. M., and M. Imboden: The role of calcium and phosphorus in determining reproductive success. J. Nutrit. 11, 147 (1936).Google Scholar
  46. Cramer, W.: Experimental production of kidney lesions by diet. Lancet 223 II, 174 (1932). Cunningham, I. J., and M. M. Cunningham: Dietary magnesium and urinary calculi. N. Z. J. Sci. Techn. 19, 529 (1938).Google Scholar
  47. D’Agata: Experimentelle kalkulöse Hydro-und Hydropyonephrose. V. Kongr. ital. urol. Ges. Padua 1926. Ref. in Z. Urol. 21, 535 (1927).Google Scholar
  48. DAs, P.: Experimental evaluation of an indigenous product for dissolution of urinary calculi. J. Indian med. Ass. 27, 50 (1956).PubMedGoogle Scholar
  49. DAs, P.: Experimental evaluation of hyaluronidase in prevention and dissolution of urinary calculi. J. Indian. med. Ass. 28, 232 (1957).PubMedGoogle Scholar
  50. DAs, P.: Formation of urinary calculi: An experimental study. J. Indian med. Ass. 33, 6 (1959). Davalos, H. A.: The experimental production of stones in the bladder. J. Urol. (Baltimore) 49, 639 (1943).Google Scholar
  51. Davidson, O. W.: The relationship of renal calculi to hyperparathyroidism. J. Urol. (Baltimore) 37, 35 (1937).Google Scholar
  52. Davies, D. W.: Acetazolamide therapy with renal complications. Brit. med. J. 1959 I, 214.Google Scholar
  53. Day, H. G., and E. V. Mccollum: Mineral metabolism growth and symptomatology of rats on a diet extremely deficient in phosphorus. J. biol. Chem. 130, 269 (1939).Google Scholar
  54. Diamanttts, M.: Production expérimentale de calcifications sous-muqueuses dans la vessie de lapins. J. Urol. méd. chir. 41, 153 (1936).Google Scholar
  55. Dick, H. J., and J. T. Prior: Experimental acute metastatic calcification in the kidney of rats. Amer. J. clin. Path. 21, 409 (1951).Google Scholar
  56. DIxoN, W. E., and J. C. HoYle: The effects of irradiated ergosterol in large doses. Brit. med. J. 2, 832 (1928).Google Scholar
  57. Domanski, T. J.: Experimental urolithiasis: Calcium oxalate stone. Amer J. clin. Path. 20, 707 (1950).Google Scholar
  58. Duguid, J. B., M. M. Duggan and J. Goiigh: The toxicity of irradiated ergosterol. J. Path. Bact. 33, 353 (1930).Google Scholar
  59. Dulce, H. J., u. H. Haase: Papierchromatographische Untersuchungen experimentell erzeugter Harnkonkremente und der Harnkolloide während sog. Steinkrisen bei Ratten. Urol. int. (Basel) 11, 86 (1961).Google Scholar
  60. Dunning, W. F., M. R. Curtis and M. E. Madson: Diethyl-stilbestrol-induced mammary gland and bladder cancer in reciprocal Fl hybrids between two inbred lines of rats. Acta Un. int. Caner. 7, 238 (1951).Google Scholar
  61. Ebstein, W., u. A. Nicolaier: Über die experimentelle Erzeugung von Harnsteinen. Verh. dtsch. Ges. inn. Med. 1889, 268.Google Scholar
  62. Engel, M. B., and H. R. Catchiole: Excretion of urinary mucoprotein following parathyroid extract in rats. Proc. Soc. exp. Biol. (N. Y.) 84, 336 (1953).Google Scholar
  63. Engfeldt, B., S. Gardell, J HellstrÖM, B. Ivemark, J. Rhodin and J. Strandh: Effect of experimentally induced hyperparathyroidism on renal function and structure. Acta endocr. (Kbh.) 29, 15 (1958).Google Scholar
  64. Escudero, A., y P. Bosq: Experimentelle Steinbildung durch A-Avitaminose. Sem. méd. esp. 42 I, 1283 (1935) (a).Google Scholar
  65. Escudero, A., y P. Bosq: Einfluß des Carotins auf die experimentell durch A-Avitaminose hervorgerufene Steinbildung. Sem. méd esp. 42 I, 1632 (1935) (b).Google Scholar
  66. Ettinger, R. H., L. R. Goldbaum and C. H. Smith JR.: A simplified photometric method for the determination of citric acid in biological fluids. J. biol. Chem. 199, 531 (1952).PubMedGoogle Scholar
  67. Eveleth, D. F., F. M. BoLIx, A. I. Goldsby and K. D. Ford: Urinary calculi in lambs N. Dakota Agr. Expt. Sta. Bimonthly Bull. 10, 149 (1948).Google Scholar
  68. Eveleth, D. F., and T. W. Millen : High serum magnesium associated with urinary calculi in sheep. Vet. Med. 34, 106 (1939).Google Scholar
  69. Flippin, H. F.: Sulfonamid concretions and calculi; in A. J. Butt: Etiologic Factors in Renal Lithiasis; S. 151. Springfield, Ill. Usa: C. C. Thomas-Publisher 1956.Google Scholar
  70. Folin, O., and R. D. Bell: Applications of a new reagent for the separation of ammonia I. The colometric determination of ammonia in urine. J. biol. Chem. 29, 329 (1917).Google Scholar
  71. Folie and Wu: Zitiert nach S. R. Benedict u. J. A. Behre : Uric acid determination and distribution. J. biol. Chem. 92, 162 (1931).Google Scholar
  72. Follis, R. H.: Pathology of nutritional disease, pp. 30, 36, 45, 209, 223, 226. Springfield, Ill.: C. C. Thomas 1948.Google Scholar
  73. Fourman, J.: Two distinct forms of experimental nephrocalcinosis in the rat. Brit. J. exp. Path. 40, 464 (1959).PubMedGoogle Scholar
  74. Fujimaki, Y.: Formation of urinary and bile duct calculi in animals fed on experimental rations. Jap. med. World 6, 29 (1926).Google Scholar
  75. Gardner, W. U.: Pelvic changes occuring in male mice receiving large amount of folliculin benzoate. Proc. Soc. exp. Biol. (N. Y.) 33, 104 (1935).Google Scholar
  76. Gardner, W. U.:, and C. A. Pfeiffer: Sceletal changes in mice receiving estrogen. Proc. Soc. exp. Biol. (N. Y.) 37, 678 (1938).Google Scholar
  77. Garner, R. J.: Colometric determination of magnesium in plasma or serum by means of titan yellow. Biochem. J. 40, 828 (1946).PubMedGoogle Scholar
  78. Gasparjan, A., u. N. OwTschinnixOw: Zur Frage der Steinbildung im Organismus (Avitaminose und Steinbildung). Z. urol. Chir. 30, 365 (1930).Google Scholar
  79. Gasser, G., u. H. Zimprich: Experimentelle Untersuchungen über Entstehung und Wachstum von Harnblasensteinen an Ratten und ihre Beeinflussung. Z. Urol. 54, 177 (1961).Google Scholar
  80. Genres, R. F., and S. Raymond: A new chemical approach to the dissolution of urinary calculi. J. Urol. (Baltimore) 65, 474 (1951).Google Scholar
  81. Geinitz, W.: Tierversuche zur Verhinderung der Harnsteinbildung. Minch. med. Wschr. 98, 895 (1956).Google Scholar
  82. Geinitz, W.: Harnsteingenese und -prophylaxe. Neuere Ergebnisse aus Forschung und Klinik zur Bedeutung der Kolloide für die Urolithiasis. Fortschr. Med. 76, 83 (1958).Google Scholar
  83. Gershoff, S. N., F. F. Faragalla, D. A. Nelson and S. B. Andrus: Vitamin Bs deficiency and oxalate nephrocalcinosis in the cat. Amer. J. Med. 27, 72 (1959).PubMedGoogle Scholar
  84. Gill, W. B., B. Finlayson and C. W. Vermeulen: Experimental urolithiasis Xvi. Prevention of urinary calculi in rats by adding calcium to the diet. J. Urol. (Baltimore) 82, 256 (1959).Google Scholar
  85. Glushin, A. S., and E. R. Fischer: Renal lesions of sulfonamide type after treatment with acetazoleamide (Diamox). J. Amer. med. Ass. 160, 204 (1956).Google Scholar
  86. Gomori, G.: Distribution of phosphatase in normal organs and tissues. J. cell. comp. Physiol. 17, 71 (1941).Google Scholar
  87. Gorham, J. R., and H. J. Griffiths: Diseases and parasites of mink. Farmers Bull. No. 2050 U.S.D.A. 1952,S. 41.Google Scholar
  88. GoUgh, J., J. B. Duguid and D. R. Davies: The renal lesions in hypervitaminosis D: Observations on the urinary calcium and phosphorus excretion. Brit. J. exp. Path. 14, 137 (1939).Google Scholar
  89. Gray, J.: The effects of obstruction of the urinary tract, with particular relation to the formation of stones. Brit. J. Surg. 23, 451 (1935) (a).Google Scholar
  90. Gray, J.: The effect of experimental interference with the bloodsupply of the kidneys, with particular reference to the formation of stones. Brit. J. Surg. 23, 458 (1935) (b).Google Scholar
  91. Gray, J.: Urinary stone formation, clinical and experimental. China med. J. 50, 761 (1936).Google Scholar
  92. Green, H. N., and E. Mellanby: Vitamin A as an anti-infective agent. Brit. med. J. 2, 691 (1928).Google Scholar
  93. Groen, J.: An experimental syndrome of fatty liver, uric acid kidney stones, and acute pancreatic necrosis produced in dogs by exclusive feeding in bacon. Science 107, 425 (1948).PubMedGoogle Scholar
  94. Gross, A., et H. BoIteau: Etude expérimentale de l’alcalose, facteur favorisant de lithiase urinaire au cours de l’hyperparathyroidisme. Algérie méd. 59, 743 (1955).PubMedGoogle Scholar
  95. Gross, A., et M. S. Lulus : Etude expérimentale de l’alcalinité urinaire en tant que facteur favorisant de lithiase rénale au cours des ostéopathies décalcifiantes. Path. Biol. 7, 77 (1959).Google Scholar
  96. Gross, P., F. B. Cooper and M. L. Hagan: Urolithiasis medicamentosa caused by sulfadiazine. Amer. J. clin. Path. 11, 882 (1941).Google Scholar
  97. Gross, P., F. B. Cooper and M. L. Hagan: and M. Lewis: Urinary concretions caused by sulfapyridine. Proc. Soc. exp. Biol. (N. Y.) 40, 448 (1939).Google Scholar
  98. Grossmann, W.: Beiträge zur Pathologie und Klinik der Harnsteinkrankheit. II. Mitt. Bedingungen der Steinbildung. Z. urol. Chir. 29, 402 (1930).Google Scholar
  99. Grossmann, W.: Beiträge zur Pathologie und Klinik der Harnsteinkrankheit. Iii. Mitt. Über die Steinkrankheit der Tiere. Z. urol. Chir. 32, 375 (1931).Google Scholar
  100. Grossmann, W.: Beiträge zur Pathologie und Klinik der Harnsteinkrankheit V Mitt. Z. urol. Chir. 38, 264 (1933).Google Scholar
  101. Grove, W. J., C. W. Vermeulen, R. Goetz and H. D. Ragins: Experimental urolithiasis II. The influence of urine volume upon calculi experimentally produced upon foreign bodies. J. Urol. (Baltimore) 64, 549 (1950).Google Scholar
  102. Gruber, G. B.: Harnsteine bei Tieren. In: F. Henke u. O. Lubarsch: Handbuch der speziellen und pathologischen Anatomie und Histologie. S. 239. Berlin-Göttingen-Heidelberg: Springer Verlag 1934.Google Scholar
  103. Gudjonsson, S. V.: Experiments on vitamin A deficiency in rats and the quantitative determination of vitamin A. Acta path. microbiol. scand. Suppl. 4, 143 (1930).Google Scholar
  104. Haag, J. R., and L. S. Palmer: The effect of variations in the proportions of calcium, magnesium and phosphorus contained in the diet. J. biol. Chem. 76, 367 (1928).Google Scholar
  105. Haase, H.: Zur Morphologie der primären Formelemente bei der Harnsteinbildung. Urol. int. (Basel) 7, 96 (1958).Google Scholar
  106. Haase, H.:, u. E. Meyering : Aus z. Z. noch unveröffentlichten Untersuchungen über die experimentelle Harnsteinerzeugung (1961).Google Scholar
  107. Hager, B. H., u. T. B. Magath: The formation of vesical calculi. J. Amer. med. Ass. 90, 266 (1928).Google Scholar
  108. Hammarsten, G.: On calcium oxalate and its solubility in the presence of inorganic salts with special reference to the occurrence of oxaluria. C. R. Lab. Carlsberg Sér. physiol. 17, Nr. 11 (1929).Google Scholar
  109. Hammarsten, G.: Eine experimentelle Studie über Calciumoxalat als Steinbildner in den Harnwegen, speziell mit Rücksicht auf die Bedeutung des Magnesiums. Lunds Universitets Arsskrift, N. F. Avd. 2. Bd. 32, Nr. 12 (1937).Google Scholar
  110. Hammarsten, G.: The formation of nucleus of stone in the urinary passages. J. Path. Bact. 57, 375 (1945).Google Scholar
  111. Hammarsten, G.: On calcium oxalate stones. In A. J. Butt: Etiologic Factors in Renal Lithiasis. S. 89. Springfield, Ill. Usa: C. C. Thomas-Publisher 1956.Google Scholar
  112. Hammarsten, G.:, u. L. Lundgren: Über die experimentelle Erzeugung von Harnsteinen an der Ratte unter Acidose mit besonderer Berücksichtigung der Harnsäure-und Uratsteinbildung. Lunds Universitets Arsskrift, N. F. Avd. 2, Bd. 36, Nr. 16 (1941).Google Scholar
  113. Han, T. N.: Renaler Zwergwuchs. Dissertation Groningen/Niederlande 1939, S. 165.Google Scholar
  114. Hanzlik, P. J., M. A. Seidenfeld and C. C. Joxxson: General properties, irritant and toxic actions of ethylene glycol. J. Pharmacol. exp. Ther. 41, 387 (1931).Google Scholar
  115. Harada, A.: A contribution to the pathogenesis of renal calculi formation. Jap. J. Urol. 46, 512 (1955).Google Scholar
  116. Harada, A.: T. Kuroda, H. Kasai, S. Saito, T. Tuji, T. Inoue, S. Ohya, J. Ohtsuji, R. Nishimura and Y. Ohkubo: Several problems of urolithiasis. Verh. Ber. 42. Gen. Meet. Japan. Urol. Ass. April 1954.Google Scholar
  117. Harada, A.:, and S. Saito: On the organic substances in urinary calculi. Jap. J. Urol. 45, 589 (1954).Google Scholar
  118. Harris, L. J., and T. Moore: Hypervitaminosis and vitamin balance Iii. The pathology of hypervitaminosis D. Biochem. J. 23, 261 (1929).PubMedGoogle Scholar
  119. Harrison, H. E., and H. C. Harrison: Inhibition of urine citrate excretion and the production of renal calcinosis in the rat by acetazoleamide (Diamox) administration. J. clin. Invest. 34, 1662 (1955).PubMedGoogle Scholar
  120. Harrison, H. E., and H. C. Harrison: Induction of renal calcinosis in rats. Mod. Med. 1956 II, 128.Google Scholar
  121. Hauck, E.: 489 Kranke mit Konkrementbildung in den ableitenden Harnwegen, ein Beitrag zur Ätiologie und Meteorobiologie. Z. Urol. 37, 3 (1943).Google Scholar
  122. Hawk, P. B., B. L. Oser and W. H. Summerson: Practical Physiological Chemistry; S. 863, 13th ed. Philadelphia: The Blakiston Co. 1954.Google Scholar
  123. Hedenberg, I.: Macroscopic and microscopic changes and stone formation in the urinary tract in experimentally produced vitamin A deficiency in rats. Acta chir. scand. Suppl. 192, 7 (1954).Google Scholar
  124. Helsted, D. M., R. C. Mills, C A Elvehjem and E. B. Hart : Choline in the nutrition of chicks. J. biol. Chem. 138, 459 (1951).Google Scholar
  125. Helander, S.: On the risk of urolith formation in treatment with sulfa preparations. Acta med. scand. 134, 244 (1949).PubMedGoogle Scholar
  126. Heller, H., and S. E. Dicker : Some renal effects of experimental dietary deficiencies. Proc. roy. Soc. Med. 40, 351 (1947).Google Scholar
  127. HellstrÖM, J.: The significance of staphylococci in the development and treatment of renal and ureteral stones. Brit. J. Urol. 10, 348 (1938).Google Scholar
  128. Helsby, R., C. W. Vermeulen and R. Goetz: Experimental urolithiasis VI. Failure of hyaluronidase to inhibit growth of stones on foreign bodies in the rat. J. Urol. (Baltimore) 69, 354 (1953).Google Scholar
  129. Herklotz, K.: Unveröffentlichte Untersuchungsergebnisse aus dem Nachlaß des Autors (1944).Google Scholar
  130. Hermann, S.: Methode zur Auflösung von Phosphatkonkrementen der Harnwege. Munch. med. Wschr. 82, 540 (1935).Google Scholar
  131. Heuchel, G.: Über die Pathogenese des Sulfonamid-Nierensyndroms. Ärztl. Forsch. 4, 629 (1950).Google Scholar
  132. Higgins, C. C.: The experimental production of urinary calculi. J. Urol. (Baltimore) 29, 157 (1933).Google Scholar
  133. Higgins, C. C.: Experimental production of urinary calculi in rats. Urol. cutan. Rev. 38, 33 (1934).Google Scholar
  134. Higgins, C. C.: Production and solution of urinary calculi. J. Amer. med. Ass. 164, 1296 (1935).Google Scholar
  135. Higgins, C. C.: Urinary lithiasis. Experimental production and solution with clinical applications and end-results. J. Urol. (Baltimore) 36, 168 (1936).Google Scholar
  136. Hillenbrand, H. J., u. J. Roesner: Über die Kolloidkörperchen im Harn. Z. Urol. 48, 607 (1955).Google Scholar
  137. Hirsch, H., u. E. Voit: Experimentelle Untersuchungen über die Verhinderung der Harnsteinbildung durch Schutzkolloidvermehrung im Ham. Klin. Wschr. 32, 651 (1954).PubMedGoogle Scholar
  138. Hoff, F., u. E. Homann: Zur Frage des Einflusses von Vitamin D und Epithelkörperchenhormon auf den Kalkhaushalt. Z. ges. exp. Med. 74, 258 (1930).Google Scholar
  139. Homann, E.: Über die Wirkung des Parathormones. Klin. Wschr. 11, 1353 (1932).Google Scholar
  140. Hou, H. C.: Studies on interrelationship of vitamins and other dietary constituents. I. Vitamins A and D and other dietary constituents in relation to formation of urinary calculi. Chin. J. Physiol. 9, 299 (1935).Google Scholar
  141. Hou, H. C.: The influence of diet on the formation of urinary calculi. China med. J. 50, 787 (1936).Google Scholar
  142. Hoyle, J. C., and H. Buckland: Further observations on the effects of large doses of irradiated ergosterol. Biochem. J. 23, 558 (1929).PubMedGoogle Scholar
  143. Hoyle, J. C.: The influence of diet on the formation of urinary calculi. China med. J. 50, 787 (1936).Google Scholar
  144. Hoyle, J. C., and H. Buckland:Hryntschak, T.: Über die Rolle der Staphylokokken für die Entstehung der sekundären Harnsteine. Klirr Wschr. 12, 63 (1933).Google Scholar
  145. Hoyle, J. C.: The influence of diet on the formation of urinary calculi. China med. J. 50, 787 (1936).Google Scholar
  146. Hoyle, J. C., and H. Buckland: Experimentelle Untersuchungen zur Harnsteinentstehung. Z. urol. Chir. 40, 211 (1935).Google Scholar
  147. Hubbel, R. B., L. B. Mandel and A. J. Wakeman : A new salt mixture for use in experimental diets. J. Nutrit. 14, 273 (1937).Google Scholar
  148. Hueper, W.: Metastatic calcifications in the organs of the dog after injections of parathyroid extract. Arch. Path. (Chicago) 3, 14 (1927).Google Scholar
  149. Hume, E. M., and H. H. Smith: A critical execution of methods of evaluating vitamine A by means of the growth rats. Biochem. J. 22, 504 (1928).PubMedGoogle Scholar
  150. Hunter, A., M. H. Givens and C. M. Guion: Studies in the biochemistry of purine metabolism. I. The excretion of purine catabolites in the urine of marsupials, rodents and carnivores. J. biol. Chem. 18, 387 (1914).Google Scholar
  151. Hunters D., and H. M. Turnbull: Hyperparathyroidism. Brit. J. Surg. 19, 203 (1931).Google Scholar
  152. Ivy, A. C., M. I. Grossman and W. H. Bachrach: Peptic ulcer. Philadelphia: Blakiston 1950.Google Scholar
  153. Jiki, J.: Das Vitamin A und die Harnsteinbildung. Z. Urol. 32, 750 (1938).Google Scholar
  154. Johnsox, D. W., L. S. Palmer and J. W. Nelson: Failure of dietary magnesium imbalance to produce urinary calculi in wethers. Vet. Med. 34, 353 (1940).Google Scholar
  155. Johnson, R. G.: Prevention and dissolution of calculi in rats with fluoracetate and citric acid. J. Urol. (Baltimore) 82, 261 (1959).Google Scholar
  156. Johnson, R. G.:, and B. L. Stiefbold: The effect of urea, magnesium chloride and low protein diet on the production of calcium oxalate vesical calculi in the rat. J. Urol. (Baltimore) 81, 691 (1959).Google Scholar
  157. Justin-BesanÇON, I., et S Lamotte-Barillon : Quelques données récentes sur la pathogenic de la lithiase rénale. Sem. Hôp. Paris 24, 1984 (1948).Google Scholar
  158. Karcher, G., u. K. H. ’Inne: Tierexperimenteller Beitrag zur Harnsteinentstehung. Z. Urol. 53, 17 (1960).PubMedGoogle Scholar
  159. Keyser, L. D.: The mechanism of the formation of urinary calculi. Ann Surg. 77, 210 (1923) (a).Google Scholar
  160. Keyser, L. D.: The etiology of urinary lithiasis; an experimental study. Arch. Surg. (Chicago) 6, 523 (1923) (b).Google Scholar
  161. Keyser, L. D.: The etiology of urinarylithiasis; an experimental study. Arch. Surg. (Chicago) 6, 525 (1928).Google Scholar
  162. Keyser, L. D.: Urinary lithiasis. J. Urol. (Baltimore) 50, 169 (1943).Google Scholar
  163. Keyser, L. D.: Studies in urinary calculosis. J. Urol. (Baltimore) 54, 194 (1945).Google Scholar
  164. Koburg, E., P. Wienert U. A. Goebel: Experimentelle Untersuchungen zur Frage der Nephrokalzinose bei Alkalose und Azidose. Beitr. path. Anat. 120, 424 (1959).Google Scholar
  165. Koch, FR. E.: Experimentelle Untersuchungen über die Nierensteinbildung. Z. Urol., Sonderheft Verh. Ber., S. 110. Urol. Tg. München 1949. Leipzig: Thieme-Verlag 1950.Google Scholar
  166. Koch, FR. E.: Weitere Untersuchungsergebnisse zur Frage der Nierensteinbildung. Med. Welt 20, 876 (1951).PubMedGoogle Scholar
  167. Koch, FR. E.: Experimentelle Therapie der Nierensteinkrise. Therapiewoche 1, 507 (1952).Google Scholar
  168. Koch, FR. E.: Tierexperimentelle Befunde am Gefäßsystem der Niere während der Harnsteinbildung. Arch. klin. Chir. 282, 954 (1955).Google Scholar
  169. Koch, FR. E., u. H. Haase: Tierexperimentelle Befunde am Gefäßsystem der Niere im Verlaufe von Konkrementbildungskrisen. Wissenschaft f. d. Praxis, Vorträge der 3. wiss. Ärztetagung Nürnberg 1952.Google Scholar
  170. Kocu, FR. E., u. H. Haase : Die Genese der Steinbildung in den Harnwegen nach den neuesten Forschungsergebnissen Wildunger Hefte 1953, H. 2.Google Scholar
  171. Kocu, FR. E., u. H. Haase: Tierexperimentelle Befunde am Gefäßsystem der Niere während der Harnsteinbildung. Madaus Jber. 8, 43 (1954).Google Scholar
  172. Kocu, FR. E., u. H. Haase:Tierexperimentelle Untersuchungen über die Beeinflussung von Kalkmangelzuständen mit natürlichen Kalksubstanzen. Arzneimittel-Forsch. 4, 437 (1954).Google Scholar
  173. Kocu, FR. E., u. H. Haase:Constatations concernant l’état du système vasculaire du rein pendant la lithiase urinaire, faites au cours d’expériences sur les animaux. Avenir méd. (Lyon) 53, 27 (1956).Google Scholar
  174. Kocu, FR. E., u. H. Haase:u. M. L. Marek: Experimentelle Untersuchungen über die Bedeutung der Ernährung für die Harnsteinbildung. Madaus Jber. 1952, S. 124.Google Scholar
  175. Kocu, FR. E., u. H. Haase:u. M. L. Marek: Zur Frage des Spontanzerfalls von Harnkonkrementen. Munch. med. Wschr. 95, 440 (1953).Google Scholar
  176. Krook, L., and G. Arwedsson: On urolithiasis in the dog. Nord. vet. med. 8, 65 (1956).Google Scholar
  177. KttMita: Experimentelle Untersuchungen über die nach der Anwesenheit von Steinen auftretenden Veränderungen im Harnapparate. Mitt. Grenzgeb. Med. Chir. 20, 565 (1909).Google Scholar
  178. KusAno, H.: Studies on salivary calculus. J. Kureme Med. Ass. 17, 5, 152 (1954).Google Scholar
  179. LacapÈRE, J.: Note sur l’uraturie des goutteux au cours des cures de benemide. Rev. Rhum. 25, 293 (1958).PubMedGoogle Scholar
  180. Lacassagne, A.: Modification de l’épithélium vésicale chez la souris atteinte de retention urinaire â la suite d’injection d’oestrone. C. R. Soc. Biol. (Paris) 120, 833 (1935).Google Scholar
  181. Langen, C. D. DE: Stone formation and diet. Meded. Dienst volksgezd. 18, 315 (1929).Google Scholar
  182. Lebon, J., M. Fabregoule et A. Gross: Lithiase urinaire et affections ossentes. Verh. Ber. IV. Congr. med. intern. d’Evian, S. 105. Paris: Vigot Frères 1955.Google Scholar
  183. Leersum, E. C. Van: Vitamin A deficiency and urolithasis. J. biol. Chem. 76, 137 (1928).Google Scholar
  184. Lehr, D., W. Antopol and J. Churg: Massive acute precipitation of free sulfathiazole in the urinary tract. Science 92, 434 (1940).PubMedGoogle Scholar
  185. Lelesz, E., u. A. Przezdziecka: Zit. nach A. Polak: Experimentelle Erzeugung von Nierenund Blasensteinen durch Ernährungsänderung. Dissertation Amsterdam 1936, S. 15.Google Scholar
  186. Leoschke, W. L., and C. A. Elvehjem: Prevention of urinary calculi formation in mink by alteration of urinary pH. Proc. Soc. exp. Biol. (N. Y.) 85, 42 (1954).Google Scholar
  187. Leoschke, W. L., E. Zikria and C. A. Elvehjem: Composition of urinary calculi in mink. Proc. Soc. exp. Biol. (N. Y.) 80, 291 (1952).Google Scholar
  188. Leoschke, W. L., E. Zikria and C. A. Elvehjem:Lindley, C. E., H. H. Briigman, T. J. Cunha and E. W. Warwick: The effect of Vitamin A deficiency on semen quality and the effect of testosterone and pregnant mare serum on Vitamin A deficient rams. J. Animal Sci. 8, 590 (1949).Google Scholar
  189. Leoschke, W. L., E. Zikria and C. A. Elvehjem: E. D. Taysom, W. E. Ham and B. H. Schneider: Urinary calculi in sheep. J. Animal Sci. 12, 704 (1953).Google Scholar
  190. Wenhaupt, E., M. P. Schulman and D. M. Greenberg: Basic histologic lesions of magnesium deficiency in the rat. Arch. Path. (Chicago) 49, 127 (1950).Google Scholar
  191. Losee, F. L., and L. J. Gehende: Caries suspectibility in the Nmri strain of Osborne-Mendel rats. Nay. Med. Res. Inst. Rept. 15, 199 (1957).Google Scholar
  192. Madaus, G., u. FR. E. KocH: Die experimentelle Erzeugung von Nierensteinen und deren Prophylaxe mit Rubia tinctorum. Z. exper. Med. 109, 517 (1941).Google Scholar
  193. Mandl, F.: Klinisches und Experimentelles zur Frage der lokalisierten und generalisierten Ostitis fibrosa. Arch. klin. Chir. 143, 245 (1926).Google Scholar
  194. Mandl, F., u. R. UebelhÖR: Parathormon Ostitis fibrosa Nierenstein (Experimentelle Studie). Zbl. Chir. 60, 68 (1933).Google Scholar
  195. Mandl, F., u. R. UebelhÖR:Mann, F. C.: Studies on the dehepatized animal. J. Mt Sinai Hosp. 11, 1 (1944).Google Scholar
  196. Marshall, V F, M. Schnittman, A. Davalos and A. Butterick: Cystolithiasis in rats as influenced by hyaluronidase, sex and stress. J. Urol. (Baltimore) 73, 677 (1955).Google Scholar
  197. Mccarrison, R.: The experimental production of stone-in-the-bladder with a note on pernicious anaemia and epidemic dropsy. Indian J. med. Res. 14, 895 (1926).Google Scholar
  198. Mccarrison, R.: The experimental production of stone-in-the-bladder. Indian J. med. Res. 15, 197 (1927)(a).Google Scholar
  199. Mccarrison, R.: The experimental production of stone-in-the-bladder. Indian. J. med. Res. 15, 485 (1927)(b).Google Scholar
  200. Mccarrison, R.: The experimental production of stone-in-the-bladder. Indian. J. med. Res. 15, 801 (1928).Google Scholar
  201. Mccarrison, R.: The influence of lime in favouring the production of stone-in-the-bladder in rats. Indian J. med. Res. 17, 1101 (1930) (a).Google Scholar
  202. Mccarrison, R.: The relative potency of certain cereal grains in favouring the formation of stone in rats. Indian. J. med. Res. 17, 1103 (1930) (b).Google Scholar
  203. Mccarrison, R.: The experimental production of stone-in-the-bladder. Indian. J. med. Res. 17, 1115 (1930)(c).Google Scholar
  204. Mccarrison, R.: Further researches on stone. Indian. J. med. Res. 18, 903 (1931) (a).Google Scholar
  205. Mccarrison, R.: On the effect of milk in preventing the formation of calcium stones in the urinary tract of albino rats. Indian J. med. Res. 19, 54 (1931) (b).Google Scholar
  206. Mccollum, E. V.: Our present knowledge of nutrition; in lectures on nutrition, Philadelphia 1925, 137.Google Scholar
  207. Zit. n. Van Leersum, E. C.: J. biol. Chem. 76, 137 (1928).Google Scholar
  208. Mccollum, E. V.:Mccollum, E. V., u. N. Simmonds: Neue Ernährungslehre, S. 256. Herausgegeben von L. Asher. Berlin-Wien: Verlag Urban u. Schwarzenberg 1928.Google Scholar
  209. Mccollum, E. V.: P. G. Shipley and E. A. Park: Studies on experimental rickets Viii: The production of rickets by diets low in phosphorus and fat-soluble A. J. biol. Chem. 47, 507 (1921).Google Scholar
  210. Mcdonald, D. F., and R. A. Eddings: Influence of hypophysectomie and replacement therapy on experimentally induced calculi in rats. J. Urol. (Baltimore) 77, 238 (1957).Google Scholar
  211. Mcdonald, D. F., and P. G. Huffman: Influence of sex hormones on incidence of experimentally induced vesical calculi in rats. Trans. west. Sect. Amer. urol. Ass. 22, 166 (1955).PubMedGoogle Scholar
  212. Mcdonald, D. F., and M. O. Orallo : Dissolution of experimentally induced vesical calculi in rats by sodium phytate and sodium neutral phosphate treatment. J. Urol. (Baltimore) 81, 534 (1959).Google Scholar
  213. Mendel, L. B.: Vortrag 1920; zit. n. E. C. Van Leersum J biol. Chem. 76, 137 (1928).Google Scholar
  214. Michaux, A.: Les teneurs en calcium des poumons et des reins chez les cobayes normaux, inanitiés ou atteints de scorbut aigée et de scorbut chronique. Observation de certains troubles vésicaux chez les carencés. C. R. Acad. Sci. (Paris) 199, 233 (1934).Google Scholar
  215. Miller, G. H., W. H. Chapman, L. Seibutis and C. W. Vermeulen: Experimental urolithiasis XI. Furadantin treatment of experimental urinary tract infection and its influence on stone growth. J. Urol. (Baltimore) 76, 42 (1956).Google Scholar
  216. Miller, G. H., W. H. Chapman, L. Seibutis and C. W. Vermeulen: C. W. Vermeulen and J. D. Moore: Experimental urolithiasis Xiv. C.lcium oxalate solubility in urine. J. Urol. (Baltimore) 79, 607 (1958).Google Scholar
  217. Milton, C., and J. M. Axelrod : Calculi and other stones found in mammals. J. Mammalogy 32, 139 (1951).Google Scholar
  218. Molitor, H., and H. Robinson: Toxic manifestations after oral administration of sodium sulfapyridine. Proc. Soc. exp. Biol. (N. Y.) 41, 409 (1939).Google Scholar
  219. Morgan, A. F., and Z. Samisoh: The sequence and extent of tissue changes resulting from moderate doses of viosterol and parathyroid extract. J. biol. Chem. 108, 741 (1935).Google Scholar
  220. Morris, P. G., and H. Steenbock: Citrate lithiasis inthe rat. Amer. J. Physiol. 167, 698 (1951).PubMedGoogle Scholar
  221. Mouriquand, G., J. Rollet, V. Edel et H. Tete: La lithiase urinaire liée a l’avitaminose A. Presse méd. 48, 529 (1940).Google Scholar
  222. Ller, H. G.: Geformte Harnbestandteile nach Sulfonamidgaben und Möglichkeiten zu ihrer Verhinderung. Z. Urol., Sonderheft Verh. Ber. Urol. Tg. Düsseldorf 1951. S. 363. Leipzig: Thieme-Verlag 1952.Google Scholar
  223. Ller, H. G.: Nebenerscheinungen bei Sulfonamidbehandlung. Therapiewoche 2, 473 (1952).Google Scholar
  224. Ller, H. G.: Über geformte Harnbestandteile und Konkrementbildungen nach Sulfonamidgaben. Zbl. Gynäk. 79, 981 (1957).Google Scholar
  225. Murphy, G.: The role of infection in the pathogenesis of experimental urolithiasis. Bull. Johns Hopk. Hosp. 108, 16 (1961).Google Scholar
  226. Murray, E., u. E. Steinkamm : Über die Wirkung langdauernder Zufuhr von Follikelhormon auf die Harnblasen weiblicher, kastrierter Ratten. Arch. Gynäk. 164, 1 (1937).Google Scholar
  227. Nagasaw, A.: The cause of urinary calculus. J. Kurume med. Ass. 16, 935 (1953).Google Scholar
  228. Newsom, I. E.: Urinary calculi with special reference to cattle and sheep. J. Amer. vet. med. Ass. 92, 495 (1938).Google Scholar
  229. Newsom, I. E., J. W. Tobiska and H. B. Osland : The effect of rations on the production of urinary calculi in sheep. Col. Agr. Exp. Sta. Tech. Bull. 31, 42 (1943).Google Scholar
  230. Nielsen, I. M.: Urolithiasis in mink: Pathology, bacteriology and experimental production. J. Urol. (Baltimore) 75, 603 (1956).Google Scholar
  231. Nielsen, I. M.:Nuck, A.: Adenographia curiosa, 3. Ausgabe, S. 78. Lugdan Batavorum: Verlag Samuel Luchtmans 1723.Google Scholar
  232. Ogura, R.: Studies on the deposition of calcium salt. Kurume Med. J. 4, 86 (1957).Google Scholar
  233. Ogura, R.:, and M. Kusuhara: Urinary calculus excretion as an indicator of calcium metabolism of the lithiasis. Kurume Med. J. 5, 130 (1958).Google Scholar
  234. Osborne, T. B., L. B. Mendel and E. L. Ferry: The incidence of phosphatic urinary calculi in rats fed on experimental rations. J. Amer. med. Ass. 69, 32 (1917).Google Scholar
  235. Perlmann, S., u. W. Weber: Experimentelle Erzeugung von Blasensteinen durch Avitaminose. Dtsch. med. Wschr. 54, 1045 (1928) (a).Google Scholar
  236. Perlmann, S., u. W. Weber: Weitere Erfahrung mit der experimentellen Blasensteinerzeugung durch Avitaminose. Munch. med. Wschr. 75, 2167 (1928) (b).Google Scholar
  237. Perlmann, S., u. W. Weber: Zur experimentellen Blasensteinerzeugung. Munch. med. Wschr. 77, 680 (1930).Google Scholar
  238. Persky, L., D. Chambers and A. Potts: Calculus formation and ureteral colic following acetazoleamide (Diamox) therapy. J. Amer. med. Ass. 161, 1625 (1956).Google Scholar
  239. Polak, A.: On the relation between kidneystone-and bladderstone-formation and nutrition. Arch. néerl. Physiol. 19, 176 (1934).Google Scholar
  240. Polak, A.: Experimentelle Erzeugung von Nieren-und Blasensteinen durch Ernährungsänderung. Dissertation Amsterdam 1936 (a).Google Scholar
  241. Polar, A.: Connection between formation of renal and vesical calculi and diet. Ned. T. Geneesk. 89, 5648 (1936) (b).Google Scholar
  242. Polar, A.: Wéitete Úntersuchungen über die Bildung und Therapie von Nieren-und Blasensteinen. Ned. T. Geneesk. 83, 4009 (1939).Google Scholar
  243. Polar, A., u. J. G. Brzenne : Einfluß der Harnreaktion auf experimentell erzeugte Nieren-und Blasensteine. Ned. T. Geneesk. 82, 383 (1938).Google Scholar
  244. Polar, A., u. A. Piet: Beziehungen zwischen Harnreaktion und Bildung von Nieren-und Blasensteinen. Ned. T. Geneesk. 81, 4029 (1937).Google Scholar
  245. Polar, A., u. A. Piet:, and I. A. Stokvis: On the dose of vitamin A in the form of carotene. Arch. néerl. Physiol. 16, 542 (1931).Google Scholar
  246. Powers, H. H., and P. Levantin: A method for the determination of oxalic acid in urine. J. biol. Chem. 154, 207 (1944).Google Scholar
  247. Prlen, E. L., and C. Frondel: Studies in urolithiasis I. The composition of urinary calculi. J. Urol. (Baltimore) 57, 949 (1947).Google Scholar
  248. Rake, G., H. B. Van Dyke and W. C. Corwin: Pathologic changes following prolonged administration of sulfathiazole and sulfapyridine. Amer. J. med. Sci. 200, 353 (1940).Google Scholar
  249. Randall, A.: The origin and growth of renal calculi. Ann. Surg. 105, 1009 (1937).PubMedGoogle Scholar
  250. Rake, G., H. B. Van Dyke and W. C. Corwin: The etiology of primary renal calculus. Int. Abstr. Surg. 71, 209 (1940).Google Scholar
  251. Ranganathan, S.: Researches on stone. Studies in calcium and phosphorus metabolism. Indian J. med. Res. 19, 1 (1931).Google Scholar
  252. Ranganathan, S.: Attempts to production acid calculi in albino rats. Indian J. med. Res. 22, 71 (1934).Google Scholar
  253. Reen, R. Van, N. Indacochea and W. C. Hess : Urolithiasis in the rat II. Studies on the effect of diet on the excretion of calcium, citric acid and phosphate. J. Nutrit. 69, 397 (1959).Google Scholar
  254. Reen, R. Van, H. W. Lyon and F. L. Losee: Studies on mineral metabolism in the albino rat I. Occurrence of urinary calculi. Nay. Med. Res. I.st. Rept. 16, 73 (1958).Google Scholar
  255. Reen, R. Van, H. W. Lyon and F. L. LosEE: Urolithiasis in the rat I. The influence of diet on the formation and prevention of calcium calculi. J. Nutrit. 69, 392 (1959).Google Scholar
  256. Riegel, C., H. P. Roister, G. J. Gislason and P. B. Hugues: Chemical studies in hyperparathyroidism and urolithiasis. J. Urol. (Baltimore) 57, 192 (1947).Google Scholar
  257. Robbins, L. C.: Osteitis fibrosa cystica and renal calculi without hypercalcaemia. J. Amer. med. Ass. 104, 117 (1933).Google Scholar
  258. Rosenbach: Kritischer und experimenteller Beitrag zur Frage der Entstehung der Nierensteine. Mitt. Grenzgeb. Med. Chir. 22, 630 (1911).Google Scholar
  259. Rosenow, E. C.: The etiology of cholecystitis and gallstones and their production by intravenous injection of bacteria. J. infect. Dis. 19, 527 (1916).Google Scholar
  260. Rosenow, E. C.:, and J. G. Meisser : Nephritis and urinary calculi after production of chronic foci of infection. J. Amer. med. Ass. 78, 266 (1922).Google Scholar
  261. Rosenow, E. C.: The production of urinary calculi by the devitalization and infection of teeth in dogs with streptococci from cases of nephrolithiasis. Arch. intern. Med. 31, 807 (1923).Google Scholar
  262. Rost, F.: Tuber Blasen-und Nierensteine im Tierversuch. Arch. klin. Chir. 162, 701 (1930).Google Scholar
  263. Rusin-, S. H., J. Scheiner and E. Hirschberg: The availability of vitamin B6 in yeast and liver for growth of Saccharomyces carlsbergensis. J. biol. Chem. 167, 599 (1947).Google Scholar
  264. Sager, R. H., and B. Spargo: The effects of a low phosphorus ration on calcium metabolism in the rat with the production of calcium citrate urinary calculi. Metabolism 4, 519 (1955).PubMedGoogle Scholar
  265. Saiki, S.: Vitamin D and calculi formation. J. Orient. Med. 19, 57 (1933).Google Scholar
  266. Sambhavaphol, P., E. B. Boswirth and C. M. Mccay: Calculi and kidney calcification from feeding milk diets to rats and hamsters. Amer. J. clin. Nutr. 6, 159 (1958).PubMedGoogle Scholar
  267. Sarma, P. S., E. E. Snell and C. A. Elvehjem: The bioassay of vitamin Bs in natural materials. J. Nutr. 33, 121 (1947).PubMedGoogle Scholar
  268. Saxton, J. A., G. A. Sperling, L. L. Barnes and C. M. Mccay: Pathologic studies of rats fed different amounts of fluid throughout life. J. Geront. 8, 255 (1953).PubMedGoogle Scholar
  269. Scheie, H. G.: Diamox and therapy of glaucoma. Amer. J. Ophthal. 39, 887 (1955).Google Scholar
  270. Schenken, J. R., E. L. Burns and W. M. Mccord: Occurrence of urinary calculi in inbred strain (C8H) of mice treated with estrogen. Endocrinology 30, 344 (1942).Google Scholar
  271. Schmidt-Nielsen, B., u. K. Schmidt-Nielsen : Kalkmangel und Nierensteine, hervorgerufen durch Spinat. Nord. Med. 23, 1463 (1944).Google Scholar
  272. Schneider, H., and H. Steenbock: Calcium citrate urolithiasis on a low phosphorus diet. J. Urol. (Baltimore) 43, 339 (1940).Google Scholar
  273. Schrader, G. A., C. O. Prickett and W. D. Salmon: Symptomatology and pathology of potassium and magnesium deficiencies in rat. J. Nutr. 14, 85 (1937).Google Scholar
  274. Selye, H.: Rolle der Nebennierenrinde bei der Entstehung verschiedenartiger Blutgefäßveränderungen. Munch. med. Wschr. 98, 1015 (1956).Google Scholar
  275. Shigematsu, S.: Eine elektronenmikroskopische Betrachtung über die Entstehung der Nierensteine. Urolog. Universitätsklinik Kurume, Japan, 1957.Google Scholar
  276. Snapper, I., W. M. Bendien and A. Polak: Observations on the formation and the prevention of calculi. Brit. J. Urol. 8, 337 (1936).Google Scholar
  277. Sompolinsky, D.: Urolithiasis in mink. Cornell Vet. 40, 367 (1950).PubMedGoogle Scholar
  278. Specht, H. voN: Nierenschädigung durch Sulfonamide. Dissertation Hamburg 1951.Google Scholar
  279. Stammer, W.: Klinik und Praxis der Urologie. Bd. 1, S. 319. Stuttgart: Georg Thieme-Verlag 1959.Google Scholar
  280. Steiner, M., M. R. Greene and B. Kramer : The effect of vitamin A-deficiency on experi- mental tuberculosis in the guinea pig and rabbit. Amer. Rev. Tubers. 36, 222 (1937).Google Scholar
  281. Steiner, M., B. Zuger and B. Kramer : Production of calculi in guinea pigs by feeding them a diet deficient in vitamin A Arch. Path. (Chicago) 27, 104 (1939).Google Scholar
  282. Studensky, N.: Zur Lehre von der Bildung der Harnsteine. Dtsch. Z. Chir. 7, 171 (1877).Google Scholar
  283. Suby, H. J., and R. M. Suby: Experimental production of kidney stones with urea-splitting organisms. J. Urol. (Baltimore) 57, 995 (1947).Google Scholar
  284. Studensky, N.:Sumo, C. J.: Effects of subcutaneous injection of estrogen upon skeleton in immature mice. Proc. Soc. exp. Biol. (N. Y.) 44, 151 (1940).Google Scholar
  285. Talbott, J. H.: Selected aspects of acute and chronic gouty arthritis; an internist’s interpretation of an orthopaedist’s experiences with gout and gouty arthritis. J. Bone Jt. Surg. 40, 994 (1958).Google Scholar
  286. Tardo: Steinbildung an implantierten Fremdkörpern. V. Kongr. ital. urol. Ges. Padua 1926, ref. in Z. Urol. 21, 535 (1927).Google Scholar
  287. Thaddea, S., u. R. ZoLoff: Experimentelle Untersuchungen über Steinbildung in den Harnwegen nach Sulfonamidzufuhr. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 202, 249 (1943) (a).Google Scholar
  288. Thaddea, S., u. R. ZoLoff: Über die Steinbildung in den Nieren und abführenden Harnwegen nach oraler Eubasinanwendung bei der Ratte. Z. Urol. 37, 248 (1943) (b).Google Scholar
  289. Tisdall, F. F., and B. Kramer: Methods for the direct quantitative determination of sodium, potassium and magnesium in urine and stools. J. biol. Chem. 48, 1 (1921).Google Scholar
  290. Toomey, J. A.: Urinary concretions and sulfapyridine. J. Amer. med. Ass. 113, 250 (1939).Google Scholar
  291. Tsugawa, R.: The significance of focal infection in urolithiasis. Jap. J. Urol. 52, 216 (1961).Google Scholar
  292. Tuffier, M.: Lithiase urinaire expérimentale. Arch. Sei. physiol. 5, 361 (1893) (a).Google Scholar
  293. Toomey, J. A.: Lithiase urinaire artificielle. Bull. Soc. anat. Paris 68, 49 (1893) (b).Google Scholar
  294. Tyson, D., and A. H. Smith: Tissue changes associated with vitamin A deficiency in the rat. Amer. J. Path. 5, 57 (1929).PubMedGoogle Scholar
  295. Udall, R. H., A. W. Deem and D. D. Maag: Studies on urolithiasis. I. Experimental production associated with feeding in steers. Amer. J. vet. Res. 19, 825 (1958).Google Scholar
  296. Uebel, H.: Histologische Probleme der formalen Steingenese. Urol. int. (Basel) 7, 113 (1958). Ungar, H.: Experimental production of urate calculi in the urinary tract of white rats. Brit. J. exp. Path. 26, 363 (1945).Google Scholar
  297. Uebel, H.: Transformation of the hepatic vasculature of rats following protacted experimental poisoning with carbon tetrachloride; its possible relation to the formation of urate calculi in the urinary tract. Amer. J. Path. 27, 871 (1951).Google Scholar
  298. Uebel, H.:, and R. Ungar: Further studies on the pathogenesis of urate calculi in the urinary tract of white rats. Amer. J. Path. 28, 291 (1952).Google Scholar
  299. Verkoren, J.: Das Vorkommen von Zitronensäure in Nieren-und Blasensteinen von Ratten. Ned. T. Geneesk. 81, 672 (1937).Google Scholar
  300. Vermeulen, C. W., W. J. Grove, R. Goetz, H. D. Ragins and N. O. Correll : Experimental urolithiasis I. Development of calculi upon foreign bodies surgically introduced into bladders of rats. J. Urol. (Baltimore) 64, 541 (1950).Google Scholar
  301. Vermeulen, C. W., H. D. Ragins, W. J. Grove and R. Goetz: Experimental urolithiasis Iii. Prevention and dissolution of calculi by alteration of urinary pH. J. Urol. (Baltimore) 66, 1 (1951).Google Scholar
  302. Vermeulen, C. W., H. D. Ragins, W. J. Grove and R. Goetz: R. Goetz, H. D. Ragins and W. J. Grove: Experimental urolithiasis IV. Prevention of ammonium phosphate calculi by reducing the magnesium intake or by feeding an aluminium gel. J. Urol. (Baltimore) 66, 6 (1951).Google Scholar
  303. Vermeulen, C. W., H. D. Ragins, W. J. Grove and R. Goetz: C. R. H.Lsby and R. Goetz: Experimental urolithiasis V. Prevention and dissolution of foreign body calculi by infection with Salmonella enteritidis. J. Urol. (Baltimore) 68, 790 (1952).Google Scholar
  304. Vermeulen, C. W., H. D. Ragins, W. J. Grove and R. Goetz:, and R. Goetz: Experimental urolithiasis Vii: Role of sex and genetic strain in determining chemical composition of stones in rats. J. Urol. (Baltimore) 72, 93 (1954) (a).Google Scholar
  305. Vermeulen, C. W., H. D. Ragins, W. J. Grove and R. Goetz: Experimental urolithiasis Viii. Furadantin in treatment of experimental proteus infection with stone formation. J. Urol. (Baltimore) 72, 99 (1954) (b).Google Scholar
  306. Vermeulen, C. W., H. D. Ragins, W. J. Grove and R. Goetz: Experimental urolithiasis IX: Influence of infection on stone growth in rats. J. Urol. (Baltimore) 72, 761 (1954) (c).Google Scholar
  307. Vermeulen, C. W., H. D. Ragins, W. J. Grove and R. Goetz: G. H. Miller and W. H. Chapman: Experimental urolithiasis X. On the state of calcium in the urine. J. Urol. (Baltimore) 75, 592 (1956).Google Scholar
  308. Vermeulen, C. W., B. Finlayson and W. Chapman: Experimental urolithiasis Xii. Influence of urinary glucuronide on solubility of calcium phosphate and stone formation. J. Urol. (Baltimore) 77, 685 (1957).Google Scholar
  309. Vermeulen, C. W., B. Finlayson and W. Chapman: E. S. Lyon and G. H. Miller: Experimental urolithiasis Xiii. Calcium phosphate solubility in urine as measured by a precipitation test. J. Urol. (Baltimore) 79, 596 (1958).Google Scholar
  310. Vermeulen, C. W., B. Finlayson and W. Chapman: W. B. Gill and W. H. Chapman: Experimental urolithiasis XV. Prevention of phosphate stones by phytate, phosphate and hexametaphosphate. J. Urol. (Baltimore) 82, 249 (1959).Google Scholar
  311. Volante, F.: Über weiche Infektionssteine im Harntrakt. Arch. ital. urol. 10, 505 (1933).Google Scholar
  312. Watchorn, E.: The effects of excessive intake of magnesium by rat; especially concerning the factors relating to the production of renal calculi. J. Hyg. (Lond.) 32, 156 (1932).Google Scholar
  313. Watchorn, E., and R. A. Mccance: Subacute magnesium deficiency in rats. Biochem. J. 31, 1379 (1937).PubMedGoogle Scholar
  314. Weller, D., M. D. Overholser and W. O. Nelson: The effect of estrin on the prostate gland of the albino rat and mouse. Anat. Rec. 65, 149 (1936).Google Scholar
  315. Wentworth, J. H., P. K. Smith and W. U. Gardner: The composition of bones of mice receiving estrogen and androgen. Endocrinology 26, 61 (1940).Google Scholar
  316. Williamson, C. S., and F. C. Mann : Studies on the physiology of the liver. Amer. J. Physiol. 65, 267 (1923).Google Scholar
  317. Wilson, J. G.: Cornification of uretheral epithelium in young male rats following injections of estrogen. Anat. Rec. 91, 46 (1945).Google Scholar
  318. Wilson, J. G.: J. A. Benjamin and A. D. Leahy : Study of experimental urinary calculi: I. Methods for producing and preventing calculous formation in the bladder and urethra of albino rats. J. Urol. (Baltimore) 54, 503 (1945).Google Scholar
  319. Wilson, J. G.: A. D. Leahy and J. A. Benjamin: Study of experimental urinary calculi: Iii. Persistence of the stone-forming tendency in estrogen-treated male rats and its relation to diet. J. Urol. (Baltimore) 56, 151 (1946).Google Scholar
  320. Yagishita, H.: Experimentelle Untersuchung über die Entstehung des Nierensteins. Jap. J. Dermat. and Urol. 31, 97 (1931).Google Scholar
  321. Yates-Bell, J. G.: Renal colic and anuria from acetazoleamide. Brit. med. J. 1958 II, 1392 Zinsser, H. H.: Urinary calculi. J. Amer. med. Ass. 174, 2062 (1960).Google Scholar

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© Springer-Verlag Berlin Heidelberg 1965

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  • Helmut Haase

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